Взаимодействие miRNA с mRNA генов апоптоза при раке легкого. Өкпе обыры кезінде miRNA-дың апоптоз гендерінің mRNA-мен байланысуы
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Ключевые слова:
miRNA, mRNA, сайты связывания, гены- мишени, апоптоз, байланысу сайттар, нысана гендер,Аннотация
Изучено связывание miRNA с mRNA генов, участвующих в апоптозе. Установлено, что несколько miRNA имеют сайты связывания с mRNA одного гена, и одна miRNA может связываться с mRNA нескольких генов. Такими miRNA являются miR-619-5p, miR-1273g-3p, miR-1273h-3p, miR-5096, miR-5095, miR-5585-5p, названные ранее уникальными. Экспрессия большинства ключевых генов апоптоза может регулироваться с помощью miRNA. Апоптозға қатысатын гендердің mRNA-мен miRNAлар байланысуы зерттелген. Кейбір miRNA- лар бір геннің mRNA-мен, бір miRNA бірнеше гендердің mRNA-мен байланыса алатыны анықталған. Мұндай miRNAларға miR-619-5p, miR-1273g-3p, miR-1273h-3p, miR-5096, miR-5095 және miR- 5585-5p жатады. Апоптоздың негізгі гендердің экспрессиясы miRNAлар арқылы реттеле алады.Библиографические ссылки
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8 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. Binding sites of miR-1273 family on the mRNA of target genes // BioMed Research International. – 2014. – Vol. 2014. – P. 620530.
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes // BioMed Research International. – 2014. – Vol. 2014. – P. 720715.
10 Liu Z.Y., Zhang G.L., Wang M.M., Xiong Y.N., Cui H.Q. MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation // Asian Pacific Journal of Cancer Prevention . – 2011. – Vol. 12(11) – P. 2819–2823.
11 Dang X., Ma A., Yang L., Hu H., Zhu B., Shang D., Chen T., Luo Y. MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells // Cancer Genetics. – 2012. – Vol.205(3) – P. 13–23.
12 Zhang J.G., Guo J.F., Liu D.L., Liu Q., Wang J.J. MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2 // Journal of Thoracic Oncology. – 2011. – Vol. 6(4). – Р. 671–678.
13 Wang R., Wang Z.X., Yang J.S., Pan X., De W., Chen L.B. MicroRNA-451 functions as a tumor suppressor in human nonsmall cell lung cancer by targeting ras-related protein 14 (RAB14) // Oncogene. – 2011. – Vol. 30(23). – Р. 2644–2658.
14 Liu J., Lu K.H., Liu Z.L., Sun M., De W., Wang Z.X. MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1 // BMC Cancer. – 2012. – Vol. 12. – Р. 519.
15 Liu Z.L., Wang H., Liu J., Wang Z.X. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN // Molecular and Cellular Biochemistry. – 2013. – Vol. 372(1–2). – Р. 35–45.
16 Wang H., Li M., Zhang R., Wang Y., Zang W., Ma Y., Zhao G., Zhang G. Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299 // Tumour Biology. – 2013. – Vol. 34(5). – Р. 3101–3109.
17 Liu X.H., Lu K.H., Wang K.M., Sun M., Zhang E.B., Yang J.S., Yin D.D., Liu Z.L., Zhou J., Liu Z.J., De W., Wang Z.X. MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5 // BMC Cancer. – 2012. – Vol. 12. – Р. 348.
2 Zhang Q., Padi S.K., Tindall D.J., Guo B. Polycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31 // Cell Death & Disease. – 2014. – Vol. 5. – e1486.
3 Otsuka K., Ochiya T. Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways // BioMed Research International. – 2014. – Vol. 2014. – P. 749724.
4 Wan L., Zhu L., Xu J., Lu B., Yang Y., Liu F., Wang Z. MicroRNA-409-3p Functions as a Tumor Suppressor in Human Lung Adenocarcinoma by Targeting c-Met // Cell Physiology and Biochemistry. – 2014. – Vol. 34(4). – P. 1273–1290.
5 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. – Vol. 10(7). – P. 423–427.
6 Berillo O., Regnier M., Ivashchenko A.T. miRAFinder and GeneAFinder scripts: large-scale searching for microRNA and related information in indexed literature abstracts // Bioinformation. – 2014. – Vol. 10(8). – P. 539–543.
7 Berillo O., Regnier M., Ivashchenko A.T. TmiRUSite and TmiROSite scripts: searching for mRNA fragments with microRNA binding sites and their encoded for amino acid sequences // Bioinformation. – 2014. – Vol. 10(7). – P. 472–473.
8 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. Binding sites of miR-1273 family on the mRNA of target genes // BioMed Research International. – 2014. – Vol. 2014. – P. 620530.
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes // BioMed Research International. – 2014. – Vol. 2014. – P. 720715.
10 Liu Z.Y., Zhang G.L., Wang M.M., Xiong Y.N., Cui H.Q. MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation // Asian Pacific Journal of Cancer Prevention . – 2011. – Vol. 12(11) – P. 2819–2823.
11 Dang X., Ma A., Yang L., Hu H., Zhu B., Shang D., Chen T., Luo Y. MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells // Cancer Genetics. – 2012. – Vol.205(3) – P. 13–23.
12 Zhang J.G., Guo J.F., Liu D.L., Liu Q., Wang J.J. MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2 // Journal of Thoracic Oncology. – 2011. – Vol. 6(4). – Р. 671–678.
13 Wang R., Wang Z.X., Yang J.S., Pan X., De W., Chen L.B. MicroRNA-451 functions as a tumor suppressor in human nonsmall cell lung cancer by targeting ras-related protein 14 (RAB14) // Oncogene. – 2011. – Vol. 30(23). – Р. 2644–2658.
14 Liu J., Lu K.H., Liu Z.L., Sun M., De W., Wang Z.X. MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1 // BMC Cancer. – 2012. – Vol. 12. – Р. 519.
15 Liu Z.L., Wang H., Liu J., Wang Z.X. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN // Molecular and Cellular Biochemistry. – 2013. – Vol. 372(1–2). – Р. 35–45.
16 Wang H., Li M., Zhang R., Wang Y., Zang W., Ma Y., Zhao G., Zhang G. Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299 // Tumour Biology. – 2013. – Vol. 34(5). – Р. 3101–3109.
17 Liu X.H., Lu K.H., Wang K.M., Sun M., Zhang E.B., Yang J.S., Yin D.D., Liu Z.L., Zhou J., Liu Z.J., De W., Wang Z.X. MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5 // BMC Cancer. – 2012. – Vol. 12. – Р. 348.
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Ivashchenko, A. T., Berillo, O. A., Niyazova, R. Y., & Zadubenko, D. V. (2015). Взаимодействие miRNA с mRNA генов апоптоза при раке легкого. Өкпе обыры кезінде miRNA-дың апоптоз гендерінің mRNA-мен байланысуы. Вестник КазНУ. Серия биологическая, 62(3), 16–21. извлечено от https://bb.kaznu.kz/index.php/biology/article/view/197
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