МикроРНК и гены, связанные с артериальной гипертензией
DOI:
https://doi.org/10.1901/exp.bio2016.4.86:98Ключевые слова:
miRNA, mRNA, сайты связывания, гены-мишени, метаболический синдром.Аннотация
Изучено связывание miRNA с mRNA генов, участвующих в развитии артериальной гипертензии. Выявлено 128 генов, участвующих в развитии артериальной гипертензии. При артериальной гипертензии установлены изменения экспрессии 25 miRNA для которых найдены их гены мишени. В mRNA генов, участвующих в развитии артериальной гипертензии, найдено 189 сайтов связывания для 82 miRNA. Из них 48 сайтов расположены в CDC, 18 - в 5´UTR и 122 - в 3´UTR. Некоторые miRNA имеют несколько сайтов связывания с mRNA генов, участвующих в развитии артериальной гипертензии. miR-1273e имеет три сайта связывания с mRNA гена F11R, miR-466 - пять сайтов связывания с mRNA гена CD36 и шесть сайтов связывания с mRNA гена MYADM, miR-574-5p имеет 9 сайтов с mRNA гена IGF1, miR-3960 - пять сайтов с mRNA гена ADRB1 и четыре сайта для mRNA гена PDE4D, miR-762 - четыре сайта для mRNA гена STK39. miR-619-5p с ΔG/ΔGm 100% связывается с генами CACNB2 и CD36, miR-3960, miR-1273e, miR-1273g-3p, miR-5095, miR-3665, miR-1273f с ΔG/ΔGm 98% связываются с генами ADRB1, BMPR2, GSTM3, F11R, ICAM1, IGF1, LEP, MYADM, NEDD4L, TBXA2R.
Библиографические ссылки
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6. Feige J.N., Gelman L., Michalik L., Desvergne B., Wahli W. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions // Prog Lipid Res.- 2006.- V.45(2).- P.120-59.
7. Kriegel A.J., Baker M.A., Liu Y., Liu P., Cowley A.W., Liang M. Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes // Hypertension.- 2015.- V.66(4).- P.793-799.
8. Zhou S., Li M., Zeng D., Xu X., Fei L., Zhu Q., Zhang Y., Wang R. A single nucleotide polymorphism in 3' untranslated region of epithelial growth factor receptor confers risk for pulmonary hypertension in chronic obstructive pulmonary disease // Cell Physiol Biochem.- 2015.- V.36(1).- P.166-178.
9. Xing Y., Zheng X., Li G., Liao L., Cao W., Xing H., Shen T., Sun L., Yang B., Zhu D. MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor β expression // Int J Biochem Cell B.- 2015.- V.64.- P.155-166.
10. Gonsalves C.S., Li C., Mpollo M.S., Pullarkat V., Malik P., Tahara S.M., Kalra V.K. Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell disease // Biochem J.- 2015.- V.468(3).- P.409-423.
11. Hromadnikova I., Kotlabova K., Ondrackova M., Pirkova P., Kestlerova A., Novotna V., Hympanova L., Krofta L. Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications // DNA Cell Biol.- 2015.- V.34(6).- P.437-457.
References
1. Samanta S, Balasubramanian S, Rajasingh S, Patel U, Dhanasekaran A, Dawn B, Rajasingh J (2016) MicroRNA: A new therapeutic strategy for cardiovascular diseases, Trends Cardiovas Med, 26(5):407-419. DOI: 10.1016/j.tcm.2016.02.004
2. Chen D, Zhao M, and Mundy GR (2004) Bone Morphogenetic Proteins, Growth Factors, 22(4):233–241. DOI: 10.1080/08977190412331279890
3. Bustelo XR, Sauzeau V, Berenjeno IM (2007) GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo, Bioessays 29(4):356–370. DOI: 10.1002/bies.20558
4. Song MS, Salmena L, Pandolfi PP (2012) The functions and regulation of the PTEN tumour suppressor, Nat Rev Mol Cell Bio, 13(5):283-296. DOI: 10.1038/nrm3330
5. Mitrea DM, Yoon MK, Ou L, Kriwacki RW (2012) Disorder-function relationships for the cell cycle regulatory proteins p21 and p27, Biol Chem, 393(4):259—274. DOI: 10.1515/hsz-2011-0254
6. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W (2006) From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions, Prog Lipid Res, 45(2): 120-59. DOI: 10.1016/j.plipres.2005.12.002
7. Kriegel AJ, Baker MA, Liu Y, Liu P, Cowley AWJ, Liang M (2015) Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes, Hypertension, 66(4):793-799. DOI: 10.1161/HYPERTENSIONAHA.115.05645
8. Zhou S, Li M, Zeng D, Xu X, Fei L, Zhu Q, Zhang Y, Wang R (2015) A single nucleotide polymorphism in 3' untranslated region of epithelial growth factor receptor confers risk for pulmonary hypertension in chronic obstructive pulmonary disease, Cell Physiol Biochem, 36(1):166-178. DOI: 10.1159/000374061
9. Xing Y, Zheng X, Li G, Liao L, Cao W, Xing H, Shen T, Sun L, Yang B, Zhu D (2015) MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor β expression, Int J Biochem Cell B, 64:155-166. DOI: 10.1016/j.biocel.2015.04.001
10. Gonsalves CS, Li C, Mpollo MS, Pullarkat V, Malik P, Tahara SM, Kalra VK (2015) Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell disease, Biochem J, 468(3):409-423. DOI: 10.1042/BJ20141138
11. Hromadnikova I, Kotlabova K, Ondrackova M, Pirkova P, Kestlerova A, Novotna V, Hympanova L, Krofta L (2015) Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications, DNA Cell Biol, 34(6):437-457. DOI: 10.1089/dna.2014.2687
2. Chen D., Zhao M., Mundy G.R. Bone Morphogenetic Proteins // Growth Factors.- 2004.- V.22(4).- P.233–241.
3. Bustelo X.R., Sauzeau V., Berenjeno I.M. GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo // Bioessays.- 2007.- V.29(4).- P.356–370.
4. Song M.S., Salmena L., Pandolfi P.P. The functions and regulation of the PTEN tumour suppressor // Nat Rev Mol Cell Bio.- 2012.- V.13(5).- P.283-296.
5. Mitrea D.M., Yoon M.K., Ou L., Kriwacki R.W. Disorder-function relationships for the cell cycle regulatory proteins p21 and p27 // Biol Chem.- 2012.- V.393(4).- P.259-274.
6. Feige J.N., Gelman L., Michalik L., Desvergne B., Wahli W. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions // Prog Lipid Res.- 2006.- V.45(2).- P.120-59.
7. Kriegel A.J., Baker M.A., Liu Y., Liu P., Cowley A.W., Liang M. Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes // Hypertension.- 2015.- V.66(4).- P.793-799.
8. Zhou S., Li M., Zeng D., Xu X., Fei L., Zhu Q., Zhang Y., Wang R. A single nucleotide polymorphism in 3' untranslated region of epithelial growth factor receptor confers risk for pulmonary hypertension in chronic obstructive pulmonary disease // Cell Physiol Biochem.- 2015.- V.36(1).- P.166-178.
9. Xing Y., Zheng X., Li G., Liao L., Cao W., Xing H., Shen T., Sun L., Yang B., Zhu D. MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor β expression // Int J Biochem Cell B.- 2015.- V.64.- P.155-166.
10. Gonsalves C.S., Li C., Mpollo M.S., Pullarkat V., Malik P., Tahara S.M., Kalra V.K. Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell disease // Biochem J.- 2015.- V.468(3).- P.409-423.
11. Hromadnikova I., Kotlabova K., Ondrackova M., Pirkova P., Kestlerova A., Novotna V., Hympanova L., Krofta L. Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications // DNA Cell Biol.- 2015.- V.34(6).- P.437-457.
References
1. Samanta S, Balasubramanian S, Rajasingh S, Patel U, Dhanasekaran A, Dawn B, Rajasingh J (2016) MicroRNA: A new therapeutic strategy for cardiovascular diseases, Trends Cardiovas Med, 26(5):407-419. DOI: 10.1016/j.tcm.2016.02.004
2. Chen D, Zhao M, and Mundy GR (2004) Bone Morphogenetic Proteins, Growth Factors, 22(4):233–241. DOI: 10.1080/08977190412331279890
3. Bustelo XR, Sauzeau V, Berenjeno IM (2007) GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo, Bioessays 29(4):356–370. DOI: 10.1002/bies.20558
4. Song MS, Salmena L, Pandolfi PP (2012) The functions and regulation of the PTEN tumour suppressor, Nat Rev Mol Cell Bio, 13(5):283-296. DOI: 10.1038/nrm3330
5. Mitrea DM, Yoon MK, Ou L, Kriwacki RW (2012) Disorder-function relationships for the cell cycle regulatory proteins p21 and p27, Biol Chem, 393(4):259—274. DOI: 10.1515/hsz-2011-0254
6. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W (2006) From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions, Prog Lipid Res, 45(2): 120-59. DOI: 10.1016/j.plipres.2005.12.002
7. Kriegel AJ, Baker MA, Liu Y, Liu P, Cowley AWJ, Liang M (2015) Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes, Hypertension, 66(4):793-799. DOI: 10.1161/HYPERTENSIONAHA.115.05645
8. Zhou S, Li M, Zeng D, Xu X, Fei L, Zhu Q, Zhang Y, Wang R (2015) A single nucleotide polymorphism in 3' untranslated region of epithelial growth factor receptor confers risk for pulmonary hypertension in chronic obstructive pulmonary disease, Cell Physiol Biochem, 36(1):166-178. DOI: 10.1159/000374061
9. Xing Y, Zheng X, Li G, Liao L, Cao W, Xing H, Shen T, Sun L, Yang B, Zhu D (2015) MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor β expression, Int J Biochem Cell B, 64:155-166. DOI: 10.1016/j.biocel.2015.04.001
10. Gonsalves CS, Li C, Mpollo MS, Pullarkat V, Malik P, Tahara SM, Kalra VK (2015) Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell disease, Biochem J, 468(3):409-423. DOI: 10.1042/BJ20141138
11. Hromadnikova I, Kotlabova K, Ondrackova M, Pirkova P, Kestlerova A, Novotna V, Hympanova L, Krofta L (2015) Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications, DNA Cell Biol, 34(6):437-457. DOI: 10.1089/dna.2014.2687
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Опубликован
2018-01-01
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Раздел
МОЛЕКУЛЯРНАЯ БИОЛОГИЯ И ГЕНЕТИКА
