ГЕНЫ СВЯЗАННЫЕ С РАЗВИТИЕМ ИШЕМИЧЕСКОГО ЗАБОЛЕВАНИЯ СЕРДЦА / ЖҮРЕКТІҢ ИШЕМИЯЛЫҚ АУРУЫ ДАМУЫМЕН БАЙЛАНЫСТЫ ГЕНДЕР
Ключевые слова:
ишемическое заболевание сердца, ген, microRNA, mRNA, диагностика, жүректің ишемиялық ауруы, микроРНҚ, мРНҚ, диагностика.Аннотация
Жүректің ишемиялық ауруы дамуымен байланысты кандидат-гендер іздестірілді. Жүректің ишемиялық ауруы дамуымен байланысты гендердің деректер қоры құрылды және осы гендердің функцияларының салыстырмалы аспектіде талдауы жүргізілді. Жүректің ишемиялық ауруы дамуына қатысатын гендердің көбісі басқа жүрек-тамыр ауруларының (миокард инфарктісі, гипертония, атеросклероз, метаболиттік синдром) дамуына байланысты екені көрсетілді. Бұл гендердің әр түрлі әлеуметтік ауруларына қатысуы қарастырылды. Жүректің ишемиялық ауруы дамуымен байланысты құрылған гендердің деректер қоры, экспрессиясы микроРНҚ-ға тәуелді гендерді табу үшін, негіз болып табылады. Молекулярлы-генетикалық маркерлер көмегімен, жүректің ишемиялық ауруын ерте диагностикалау әдістерін дамыту үшін, алынған гендердің деректер қорының пайдалануы талқыланды. Был проведен поиск генов-кандидатов, связанных с развитием ишемического заболевания сердца. Создана база данных по генам, связанным с развитием ишемического заболевания сердца и проанализированы в сравнительном аспекте функции этих генов. Показано, что многие из генов, участвующих в развитии ишемического заболевания сердца, связаны с развитием других сердечно-сосудистых заболеваний: инфаркт миокарда, артериальная гипертензия, атеросклероз, метаболический синдром. Анализируется участие этих генов в развитии различных социально значимых заболеваний. Созданная база данных по генам, связанным с развитием ишемического заболевания сердца, служит основой для выявления генов, экспрессия которых зависит от действия microRNA. Обсуждается использование полученной базы данных по генам в разработке методов ранней диагностики ишемического заболевания сердца с помощью молекулярно-генетических маркеров.Библиографические ссылки
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13. Arslan S., Korkmaz Ö., Özbilüm N., Berkan Ö. Association between NF-κBI and NF-κBIA polymorphisms and coronary artery disease // Biomedical Report. – 2015. - V. 3, N. 5. – P. 736-740.
14. Ahmadi Z., Senemar S., Toosi S., Radmanesh S. The Association of Lipoprotein Lipase Genes, HindIII and S447X Polymorphisms With Coronary Artery Disease in Shiraz City // Jounal of Cardiovascular and Thoracic Research. – 2015. - V. 7, N. 2. – P. 63-67.
15. Xiao J., Luo X., Lin H., Zhang Y., Lu Y., Wang N., Zhang Y., Yang B., Wang Z. MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts // Journal of Biological Chemistry. - 2011. - V. 286, N. 32. - P. 56-86.
16. Shan H., Zhang Y., Cai B., Chen X., Fan Y., Yang L., Chen X., Liang H., Zhang Y., Song X., Xu C., Lu Y., Yang B., Du Z. Upregulation of microRNA-1 and microRNA-133 contributes to arsenic-induced cardiac electrical remodeling // International Journal of Cardiology. - 2013. - V. 167, N. 6. - P. 2798-2805.
17. Luo X., Lin H., Pan Z., Xiao J., Zhang Y., Lu Y., Yang B., Wang Z. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart // Journal of Biological Chemistry. - 2008. - V. 283, N. 29. - P. 20045-20052.
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21. Papoutsidakis N., Deftereos S., Kaoukis A., Bouras G., Giannopoulos G., Theodorakis A., Angelidis C., Hatzis G., Stefanadis C. MicroRNAs and the heart: small things do matter // Current Topics in Medicinal Chemistry. - 2013. - V. 13, N. 2. - P. 216-230.
2. Arbour L., Asuri S., Whittome B., Polanco F., Hegele R.A. The Genetics of Cardiovascular Disease in Canadian and International Aboriginal Populations // Canadian Journal of Cardiology. - 2015. - V. 31, N 9. – P. 1094-1115.
3. Brænne I., Civelek M., Vilne B., et al. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci // Arteriosclerosis, Thrombosis, and Vascular Biology. – 2015. - V. 35, N. 10. – P. 2207-2217.
4. Hamrefors V. Common genetic risk factors for coronary artery disease: new opportunities for prevention? // Clinical Physiology and Functional Imaging. – 2015. - V. 17. - P. 128-141.
5. Cole C.B., Nikpay M., Stewart A.F., McPherson R. Increased genetic risk for obesity in premature coronary artery disease // European Journal of Human Genetics. – 2015. - V. 29. - P. 53-69.
6. Yamada Y., Matsui K., Takeuchi I., Fujimaki T. Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study // Biomedical Report. – 2015. - V. 3, N. 3. – P. 413-419.
7. Ozaki K., Tanaka T. Molecular genetics of coronary artery disease // Journal of Human Genetics. – 2015. - V. 2. - P. 250-258.
8. Neelankavil J., Rau C.D., Wang Y. The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets // Journal of Cardiothoracic and Vascular Anesthesia. – 2015. - V. 29, N. 5. – P. 1328-1332.
9. Hernesniemi J.A., Lyytikäinen L.P., Oksala N., et al. Predicting sudden cardiac death using common genetic risk variants for coronary artery disease // European Heart Journal. - 2015. - V. 36, N. 26. – P. 1669-1675.
10. Cheng Y., An B., Jiang M., Xin Y., Xuan S. Association of Tumor Necrosis Factor-alpha Polymorphisms and Risk of Coronary Artery Disease in Patients With Non-alcoholic Fatty Liver Disease // Hepatitis Monthly. – 2015. - V. 15, N. 3. – P. 68-81.
11. Liao B., Cheng K., Dong S., Liu H., Xu Z. Effect of apolipoprotein A1 genetic polymorphisms on lipid profiles and the risk of coronary artery disease // Diagnostics of Pathologies. – 2015. - V. 16, N. 10. – P. 102.
12. Cui F., Li K., Li Y., Zhang X., An C. Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population // Lipids Health Diseases. – 2014. - V. 8, N. 13. – P. 170.
13. Arslan S., Korkmaz Ö., Özbilüm N., Berkan Ö. Association between NF-κBI and NF-κBIA polymorphisms and coronary artery disease // Biomedical Report. – 2015. - V. 3, N. 5. – P. 736-740.
14. Ahmadi Z., Senemar S., Toosi S., Radmanesh S. The Association of Lipoprotein Lipase Genes, HindIII and S447X Polymorphisms With Coronary Artery Disease in Shiraz City // Jounal of Cardiovascular and Thoracic Research. – 2015. - V. 7, N. 2. – P. 63-67.
15. Xiao J., Luo X., Lin H., Zhang Y., Lu Y., Wang N., Zhang Y., Yang B., Wang Z. MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts // Journal of Biological Chemistry. - 2011. - V. 286, N. 32. - P. 56-86.
16. Shan H., Zhang Y., Cai B., Chen X., Fan Y., Yang L., Chen X., Liang H., Zhang Y., Song X., Xu C., Lu Y., Yang B., Du Z. Upregulation of microRNA-1 and microRNA-133 contributes to arsenic-induced cardiac electrical remodeling // International Journal of Cardiology. - 2013. - V. 167, N. 6. - P. 2798-2805.
17. Luo X., Lin H., Pan Z., Xiao J., Zhang Y., Lu Y., Yang B., Wang Z. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart // Journal of Biological Chemistry. - 2008. - V. 283, N. 29. - P. 20045-20052.
18. Wang N., Zhou Z., Liao X., Zhang T. Role of microRNAs in cardiac hypertrophy and heart failure // International Union of Biochemistry and Molecular Biology Life. - 2009. - V. 61, N. 6. - P. 566-571.
19. Ye Y., Perez-Polo J.R., Qian J., Birnbaum Y. The role of microRNA in modulating myocardial ischemia-reperfusion injury // Physiological Genomics. - 2011. - V. 43, N. 10. - P. 534-542.
20. Ono K., Kuwabara Y., Han J. MicroRNAs and cardiovascular diseases // Federation of European Biochemical Societies Journal. - 2011. - V. 278, N. 10. - P. 1619-1633.
21. Papoutsidakis N., Deftereos S., Kaoukis A., Bouras G., Giannopoulos G., Theodorakis A., Angelidis C., Hatzis G., Stefanadis C. MicroRNAs and the heart: small things do matter // Current Topics in Medicinal Chemistry. - 2013. - V. 13, N. 2. - P. 216-230.
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МОЛЕКУЛЯРНАЯ БИОЛОГИЯ И ГЕНЕТИКА
