microRNA и гены, связанные с метаболическим синдромом
221 57
Ключевые слова:
miRNA, mRNA, сайты связывания, гены-мишени, метаболический синдром.Аннотация
Создана база данных генов и miRNA, участвующих в развитии метаболического синдрома. mRNA 118 генов связываются с 94 miRNA с величиной ΔG/ΔGm более 90%. Для 48 miRNA сайты связывания располагаются в CDS, 19 miRNA – в 5'UTR, 43 miRNA – в 3'UTR. Для некоторых miRNA в mRNA генов-мишеней имеются полисайты: для miR-466 – четыре сайта в mRNA гена CD36 и девять сайтов в mRNA гена JAK2; для miR-619-5p – три сайта в mRNA гена LDLR и для miR-3960 - три сайта связывания в mRNA гена CEBPA. Некоторые miRNA имеют несколько генов-мишеней, участвующих в развитии метаболического синдрома. miR-3960 связывается с mRNA 4 генов, miR-466 – 6, miR-1273f, miR-5095 - 7, miR-1285-5p – 8, miR-5096 – 9, miR-5585-3p – 10, miR-1273g-3p, miR-619-5p – 13 генов-мишеней. Из 42 miRNA, принимающих участие в развитии метаболического синдрома, экспрессия 33 miRNA повышается, а девяти miRNA понижается. Некоторые miRNA имеют по семь и более генов-мишеней: miR-185-3p, miR-378g имеют по 11 генов, miR-197-3p, miR-378d – по десять, miR-150-3p, miR-378a-3p, miR-378i - по девять, miR-145-3p - восемь, miR-197-5p, miR-378b – по семь генов-мишеней.
Библиографические ссылки
Литература
1. Srikanthan K., Feyh A., Visweshwar H., Shapiro J.I., Sodhi K. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population // International Journal of Medical Sciences. – 2016. – V.13(1). – P.25-38. Doi:10.7150/ijms.13800
2. Ramic E., Prasko S., Mujanovic O.B., Gavran L. Metabolic syndrome – theory and practice // Mater Sociomed. – 2016. – V.28(1). – P.71-73. Doi: 10.5455/msm.2016.28.71-73
3. Grundy S.M. Metabolic Syndrome Pandemic // Arterioscler Thromb Vasc Biol. – 2008. – V.28. – P.629-636. Doi:10.1161/atvbaha.107.151092
4. Grundy S.M. Metabolic syndrome update // Trends in cardiovascular medicine. – 2016. – V.26. – P.364-373. Doi:10.1016/j.tcm.2015.10.004
5. O'Neill S., Bohl M., Gregersen S., Hermansen K., O'Driscoll L. Blood-Based Biomarkers for Metabolic Syndrome // Trends Endocrinol Metab. – 2016. – V.27(6). – P.363-374. Doi:10.1016/j.tem.2016.03.012
6. Vienberg S., Geiger J., Madsen S., Dalgaard L.T. MicroRNAs in metabolism // Acta Physiol. – 2016. - [Epub ahead of print]. Doi:10.1111/apha.12681
7. De Luca P., Dalton G.N., Scalise G.D., Moiola C.P., Porretti J. CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs // Oncotarget. – 2016. –V.7(14). – P. 18798-18811. Doi:10.18632/oncotarget.7711
8. Kassi E., Pervanidou P., Kaltsas G., Chrousos G. Metabolic syndrome: definitions and controversies // BMC Medicine. – 2011. – V.9. – P.48. Doi:10.1186/1741-7015-9-48
9. Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. – V.10(7). – P.423-427. Doi:10.6026/97320630010423
10. Ivashchenko A., Pyrkova A., Niyazova R. A method for clustering of miRNA sequences using fragmented programming // Bioinformation. – 2016. – V.12(1). – P.15-18. Doi:10.6026/97320630012015
11. Hjerkinn E., Arnesen H. Arterial stiffness is independently associated with interleukin- 18 and components of the metabolic syndrome // Atherosclerosis. – 2010. – V.209. – P.337-339. Doi:10.1016/j.atherosclerosis.2009.09.028
12. Arking D.E., Krebsova A., Macek Sr. M. Association of human aging with a functional variant of klotho // Proc Natl Acad Sci USA. – 2002. – V.99. – P.856-861. Doi:10.1073/pnas.022484299
13. Majumdar V., Christopher R. Association of exonic variants of Klotho with metabolic syndrome in Asian Indians // Clinica Chimica Acta. – 2011. – V.412. – P.1116-1121. Doi:10.1016/j.cca.2011.02.034
14. Niyazova R., Atambayeva S., Akimniyazova A., Pinsky I., Alybaeva A., Faye B., Ivashchenko A.T. Features of mir-466-3p binding sites in mRNA genes with different functions // International Journal of Biology and Chemistry. – 2015. – V.8 (2). – P.44-51
15. Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes // Biomed Research International. – 2014. – V.2014. – P.1-8. DOI:10.1155/2014/720715
16. Esau C., Davis S., Murray S.F., et al. Monia: miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting // Cell Metabolism. – 2006. – V.3. – P.87-98. Doi:10.1016/j.cmet.2006.01.005
17. Wang Y.T., Tsai P.C., Liao Y.C., Hsu C.Y., Juo S.H. Circulating microRNAs have a sex-specific association with metabolic syndrome // Journal of Biomedical Science. – 2013. – V.20. – P.72. Doi:10.1186/1423-0127-20-72
18. Karolina D.S., Tavintharan S., Armugam A., et al. Circulating miRNA profiles in patients with metabolic syndrome // J Clin Endocrinol Metab. – 2012. – V.97. – P.E2271-2276. Doi:10.1210/jc.2012-1996
19. Heneghan H.M., Miller N., McAnena O.J., O’Brien T., Kerin M.J. Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers // J Clin Endocrinol Metab. – 2011. V.96. – P.E846-850. Doi:10.1210/jc.2010-2701
20. Esau C., Kang X., Peralta E., et al. Griffey: MicroRNA-143 Regulates Adipocyte Differentiation // The Amer Soc for Biochem and Mol Biol. – 2004. – V.279. – P.52361-52365. Doi:10.1074/jbc.C400438200
21. Karolina D.S., Tavintharan S., Armugam A., et al. Circulating miRNA Profiles in Patients with Metabolic Syndrome // J Clin Endocrinol Metab. – 2012. – V.97(12). – P.E2271-E2276. Doi:10.1210/jc.2012-1996
22. Ramirez C.M., Dávalos A., Goedeke L., et al. miR-758 regulates cholesterol efflux through post-transcriptional repression of ABCA1 // Arterioscler Thromb Vasc Biol. – 2011. – V.31(11). – P.2707-2714. Doi:10.1161/ATVBAHA.111.232066
References
1. Srikanthan K, Feyh A, Visweshwar H, Shapiro JI, Sodhi K (2016) Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population, International Journal of Medical Sciences, 13(1):25-38. Doi:10.7150/ijms.13800
2. Ramic E, Prasko S, Mujanovic OB, Gavran L (2016) Metabolic syndrome – theory and practice, Mater Sociomed, 28(1):71-73. Doi: 10.5455/msm.2016.28.71-73
3. Grundy SM (2008) Metabolic Syndrome Pandemic, Arterioscler Thromb Vasc Biol, 28:629-636. Doi:10.1161/atvbaha.107.151092
4. Grundy SM (2016) Metabolic syndrome update, Trends in cardiovascular medicine, 26:364-373. Doi:10.1016/j.tcm.2015.10.004
5. O'Neill S, Bohl M, Gregersen S, Hermansen K, O'Driscoll L (2016) Blood-Based Biomarkers for Metabolic Syndrome, Trends Endocrinol Metab, 27(6):363-74. Doi:10.1016/j.tem.2016.03.012
6. Vienberg S, Geiger J, Madsen S, Dalgaard LT (2016) MicroRNAs in metabolism, Acta Physiol. Doi:10.1111/apha.12681
7. De Luca P, Dalton GN, Scalise GD, Moiola CP, Porretti J (2016) CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs, Oncotarget, 7(14). Doi:10.18632/oncotarget.7711
8. Kassi E, Pervanidou P, Kaltsas G, Chrousos G (2011) Metabolic syndrome: definitions and controversies, BMC Medicine, 9:48. Doi:10.1186/1741-7015-9-48
9. Ivashchenko A, Berillo O, Pyrkova A, Niyazova R, Atambayeva S (2014) MiR-3960 binding sites with mRNA of human genes, Bioinformation, 10(7):423-427. Doi:10.6026/97320630010423
10. Ivashchenko A, Pyrkova A, Niyazova R (2016) A method for clustering of miRNA sequences using fragmented programming, Bioinformation, 12(1):15-18. Doi:10.6026/97320630012015
11. Hjerkinn E, Arnesen H (2010) Arterial stiffness is independently associated with interleukin- 18 and components of the metabolic syndrome, Atherosclerosis, 209: 337-339. Doi:10.1016/j.atherosclerosis.2009.09.028
12. Arking DE, Krebsova A, Macek Sr M (2002) Association of human aging with a functional variant of klotho, Proc Natl Acad Sci USA, 99:856-61. Doi:10.1073/pnas.022484299
13. Majumdar V, Christopher R (2011) Association of exonic variants of Klotho with metabolic syndrome in Asian Indians, Clinica Chimica Acta, 412:1116-1121. Doi:10.1016/j.cca.2011.02.034
14. Niyazova R, Atambayeva S, Akimniyazova A, Pinsky I, Alybaeva A, Faye B, Ivashchenko AT (2015) Features of mir-466-3p binding sites in mRNA genes with different functions, International Journal of Biology and Chemistry, 8 (2):44-51
15. Ivashchenko A, Berillo O, Pyrkova A, Niyazova R, Atambayeva S (2014) The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes, Biomed Research International, 2014:1-8. DOI:10.1155/2014/720715
16. Esau C, Davis S, Murray SF, et al (2006) Monia: miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting, Cell Metabolism, 3:87-98. Doi:10.1016/j.cmet.2006.01.005
17. Wang YT, Tsai PC, Liao YC, Hsu CY, Juo SH (2013) Circulating microRNAs have a sex-specific association with metabolic syndrome, Journal of Biomedical Science, 20:72. Doi:10.1186/1423-0127-20-72
18. Karolina DS, Tavintharan S, Armugam A, et al (2012) Circulating miRNA profiles in patients with metabolic syndrome, J Clin Endocrinol Metab, 97:E2271-2276. Doi:10.1210/jc.2012-1996
19. Heneghan HM, Miller N, McAnena OJ, O’Brien T, Kerin MJ (2011) Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers, J Clin Endocrinol Metab, 96:E846-850. Doi:10.1210/jc.2010-2701
20. Esau C, Kang X, Peralta E, et al (2004) Griffey: MicroRNA-143 Regulates Adipocyte Differentiation, The Amer Soc for Biochem and Mol Biol, 279:52361-52365. Doi:10.1074/jbc.C400438200
21. Karolina DS, Tavintharan S, Armugam A, et al (2012) Circulating miRNA Profiles in Patients with Metabolic Syndrome, J Clin Endocrinol Metab, 97(12):E2271-E2276. Doi:10.1210/jc.2012-1996
22. Ramirez CM, Dávalos A, Goedeke L, et al (2011) miR-758 regulates cholesterol efflux through post-transcriptional repression of ABCA1, Arterioscler Thromb Vasc Biol, 31(11): 2707-2714. Doi:10.1161/ATVBAHA.111.232066
1. Srikanthan K., Feyh A., Visweshwar H., Shapiro J.I., Sodhi K. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population // International Journal of Medical Sciences. – 2016. – V.13(1). – P.25-38. Doi:10.7150/ijms.13800
2. Ramic E., Prasko S., Mujanovic O.B., Gavran L. Metabolic syndrome – theory and practice // Mater Sociomed. – 2016. – V.28(1). – P.71-73. Doi: 10.5455/msm.2016.28.71-73
3. Grundy S.M. Metabolic Syndrome Pandemic // Arterioscler Thromb Vasc Biol. – 2008. – V.28. – P.629-636. Doi:10.1161/atvbaha.107.151092
4. Grundy S.M. Metabolic syndrome update // Trends in cardiovascular medicine. – 2016. – V.26. – P.364-373. Doi:10.1016/j.tcm.2015.10.004
5. O'Neill S., Bohl M., Gregersen S., Hermansen K., O'Driscoll L. Blood-Based Biomarkers for Metabolic Syndrome // Trends Endocrinol Metab. – 2016. – V.27(6). – P.363-374. Doi:10.1016/j.tem.2016.03.012
6. Vienberg S., Geiger J., Madsen S., Dalgaard L.T. MicroRNAs in metabolism // Acta Physiol. – 2016. - [Epub ahead of print]. Doi:10.1111/apha.12681
7. De Luca P., Dalton G.N., Scalise G.D., Moiola C.P., Porretti J. CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs // Oncotarget. – 2016. –V.7(14). – P. 18798-18811. Doi:10.18632/oncotarget.7711
8. Kassi E., Pervanidou P., Kaltsas G., Chrousos G. Metabolic syndrome: definitions and controversies // BMC Medicine. – 2011. – V.9. – P.48. Doi:10.1186/1741-7015-9-48
9. Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. – V.10(7). – P.423-427. Doi:10.6026/97320630010423
10. Ivashchenko A., Pyrkova A., Niyazova R. A method for clustering of miRNA sequences using fragmented programming // Bioinformation. – 2016. – V.12(1). – P.15-18. Doi:10.6026/97320630012015
11. Hjerkinn E., Arnesen H. Arterial stiffness is independently associated with interleukin- 18 and components of the metabolic syndrome // Atherosclerosis. – 2010. – V.209. – P.337-339. Doi:10.1016/j.atherosclerosis.2009.09.028
12. Arking D.E., Krebsova A., Macek Sr. M. Association of human aging with a functional variant of klotho // Proc Natl Acad Sci USA. – 2002. – V.99. – P.856-861. Doi:10.1073/pnas.022484299
13. Majumdar V., Christopher R. Association of exonic variants of Klotho with metabolic syndrome in Asian Indians // Clinica Chimica Acta. – 2011. – V.412. – P.1116-1121. Doi:10.1016/j.cca.2011.02.034
14. Niyazova R., Atambayeva S., Akimniyazova A., Pinsky I., Alybaeva A., Faye B., Ivashchenko A.T. Features of mir-466-3p binding sites in mRNA genes with different functions // International Journal of Biology and Chemistry. – 2015. – V.8 (2). – P.44-51
15. Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes // Biomed Research International. – 2014. – V.2014. – P.1-8. DOI:10.1155/2014/720715
16. Esau C., Davis S., Murray S.F., et al. Monia: miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting // Cell Metabolism. – 2006. – V.3. – P.87-98. Doi:10.1016/j.cmet.2006.01.005
17. Wang Y.T., Tsai P.C., Liao Y.C., Hsu C.Y., Juo S.H. Circulating microRNAs have a sex-specific association with metabolic syndrome // Journal of Biomedical Science. – 2013. – V.20. – P.72. Doi:10.1186/1423-0127-20-72
18. Karolina D.S., Tavintharan S., Armugam A., et al. Circulating miRNA profiles in patients with metabolic syndrome // J Clin Endocrinol Metab. – 2012. – V.97. – P.E2271-2276. Doi:10.1210/jc.2012-1996
19. Heneghan H.M., Miller N., McAnena O.J., O’Brien T., Kerin M.J. Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers // J Clin Endocrinol Metab. – 2011. V.96. – P.E846-850. Doi:10.1210/jc.2010-2701
20. Esau C., Kang X., Peralta E., et al. Griffey: MicroRNA-143 Regulates Adipocyte Differentiation // The Amer Soc for Biochem and Mol Biol. – 2004. – V.279. – P.52361-52365. Doi:10.1074/jbc.C400438200
21. Karolina D.S., Tavintharan S., Armugam A., et al. Circulating miRNA Profiles in Patients with Metabolic Syndrome // J Clin Endocrinol Metab. – 2012. – V.97(12). – P.E2271-E2276. Doi:10.1210/jc.2012-1996
22. Ramirez C.M., Dávalos A., Goedeke L., et al. miR-758 regulates cholesterol efflux through post-transcriptional repression of ABCA1 // Arterioscler Thromb Vasc Biol. – 2011. – V.31(11). – P.2707-2714. Doi:10.1161/ATVBAHA.111.232066
References
1. Srikanthan K, Feyh A, Visweshwar H, Shapiro JI, Sodhi K (2016) Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population, International Journal of Medical Sciences, 13(1):25-38. Doi:10.7150/ijms.13800
2. Ramic E, Prasko S, Mujanovic OB, Gavran L (2016) Metabolic syndrome – theory and practice, Mater Sociomed, 28(1):71-73. Doi: 10.5455/msm.2016.28.71-73
3. Grundy SM (2008) Metabolic Syndrome Pandemic, Arterioscler Thromb Vasc Biol, 28:629-636. Doi:10.1161/atvbaha.107.151092
4. Grundy SM (2016) Metabolic syndrome update, Trends in cardiovascular medicine, 26:364-373. Doi:10.1016/j.tcm.2015.10.004
5. O'Neill S, Bohl M, Gregersen S, Hermansen K, O'Driscoll L (2016) Blood-Based Biomarkers for Metabolic Syndrome, Trends Endocrinol Metab, 27(6):363-74. Doi:10.1016/j.tem.2016.03.012
6. Vienberg S, Geiger J, Madsen S, Dalgaard LT (2016) MicroRNAs in metabolism, Acta Physiol. Doi:10.1111/apha.12681
7. De Luca P, Dalton GN, Scalise GD, Moiola CP, Porretti J (2016) CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs, Oncotarget, 7(14). Doi:10.18632/oncotarget.7711
8. Kassi E, Pervanidou P, Kaltsas G, Chrousos G (2011) Metabolic syndrome: definitions and controversies, BMC Medicine, 9:48. Doi:10.1186/1741-7015-9-48
9. Ivashchenko A, Berillo O, Pyrkova A, Niyazova R, Atambayeva S (2014) MiR-3960 binding sites with mRNA of human genes, Bioinformation, 10(7):423-427. Doi:10.6026/97320630010423
10. Ivashchenko A, Pyrkova A, Niyazova R (2016) A method for clustering of miRNA sequences using fragmented programming, Bioinformation, 12(1):15-18. Doi:10.6026/97320630012015
11. Hjerkinn E, Arnesen H (2010) Arterial stiffness is independently associated with interleukin- 18 and components of the metabolic syndrome, Atherosclerosis, 209: 337-339. Doi:10.1016/j.atherosclerosis.2009.09.028
12. Arking DE, Krebsova A, Macek Sr M (2002) Association of human aging with a functional variant of klotho, Proc Natl Acad Sci USA, 99:856-61. Doi:10.1073/pnas.022484299
13. Majumdar V, Christopher R (2011) Association of exonic variants of Klotho with metabolic syndrome in Asian Indians, Clinica Chimica Acta, 412:1116-1121. Doi:10.1016/j.cca.2011.02.034
14. Niyazova R, Atambayeva S, Akimniyazova A, Pinsky I, Alybaeva A, Faye B, Ivashchenko AT (2015) Features of mir-466-3p binding sites in mRNA genes with different functions, International Journal of Biology and Chemistry, 8 (2):44-51
15. Ivashchenko A, Berillo O, Pyrkova A, Niyazova R, Atambayeva S (2014) The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes, Biomed Research International, 2014:1-8. DOI:10.1155/2014/720715
16. Esau C, Davis S, Murray SF, et al (2006) Monia: miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting, Cell Metabolism, 3:87-98. Doi:10.1016/j.cmet.2006.01.005
17. Wang YT, Tsai PC, Liao YC, Hsu CY, Juo SH (2013) Circulating microRNAs have a sex-specific association with metabolic syndrome, Journal of Biomedical Science, 20:72. Doi:10.1186/1423-0127-20-72
18. Karolina DS, Tavintharan S, Armugam A, et al (2012) Circulating miRNA profiles in patients with metabolic syndrome, J Clin Endocrinol Metab, 97:E2271-2276. Doi:10.1210/jc.2012-1996
19. Heneghan HM, Miller N, McAnena OJ, O’Brien T, Kerin MJ (2011) Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers, J Clin Endocrinol Metab, 96:E846-850. Doi:10.1210/jc.2010-2701
20. Esau C, Kang X, Peralta E, et al (2004) Griffey: MicroRNA-143 Regulates Adipocyte Differentiation, The Amer Soc for Biochem and Mol Biol, 279:52361-52365. Doi:10.1074/jbc.C400438200
21. Karolina DS, Tavintharan S, Armugam A, et al (2012) Circulating miRNA Profiles in Patients with Metabolic Syndrome, J Clin Endocrinol Metab, 97(12):E2271-E2276. Doi:10.1210/jc.2012-1996
22. Ramirez CM, Dávalos A, Goedeke L, et al (2011) miR-758 regulates cholesterol efflux through post-transcriptional repression of ABCA1, Arterioscler Thromb Vasc Biol, 31(11): 2707-2714. Doi:10.1161/ATVBAHA.111.232066
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Как цитировать
Niyazova, R. Y., Atambayeva, S. A., Pinsky, I. V., Akimniyazova, A. N., Mamirova, A. A., Pyrkova, A. Y., Ivashchenko, A. T., & Labeit, S. B. (2016). microRNA и гены, связанные с метаболическим синдромом. Вестник КазНУ. Серия биологическая, 68(3), 152–165. извлечено от https://bb.kaznu.kz/index.php/biology/article/view/1212
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МОЛЕКУЛЯРНАЯ БИОЛОГИЯ И ГЕНЕТИКА
