Взаимодействие miRNA с mRNA генов клеточного цикла при раке легкого. Өкпе обыры кезінде miRNA-дың жасушалық циклдің гендерінің mRNA-мен байланысуы

Авторы

  • A. T. Ivashchenko Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби,
  • O. A. Berillo Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби,
  • R. Y. Niyazova Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби,
  • A. K. Shylmyrzayeva Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби,

Ключевые слова:

miRNA, mRNA, сайты связывания, гены- мишени, клеточный цикл, байланысу сайттар, нысана гендер, жасушалық цик,

Аннотация

Изучено связывание miRNA с mRNA генов, участвующих в клеточном цикле. Установлены miRNA, связывающиеся с высокой эффективностью с mRNA генов, участвующих в клеточном цикле. miR-619-5p, miR-1273f, miR-1273g-3p, miR-574-5p, miR-3960, miR-619-5p, miR-1273e, miR-5096 и miR-5095 могут связываться с mRNA нескольких генов. Уникальные miRNA могут оказывать доминирующее влияние на экспрессию существенной частибелок-кодирующих генов человека, в том числе на экспрессию генов клеточного цикла. Жасушалық циклге қатысатын гендердің mRNAмен miRNAдың байланысуы зерттелген. Жасушалық циклге қатысатын гендердің mRNA-мен жоғары эффективтілігімен байланысатын miRNAлар анықталған. miR-619-5p, miR-1273f, miR-1273g-3p, miR-574-5p, miR-3960, miR-619-5p, miR-1273e, miR-5096 және miR-5095 бірнеше гендердің mRNAмен байланыса алады.

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