The interaction of miRNA with mRNA of the cell cycle genes in lung cancer
1860 51
Keywords:
miRNA, mRNA, binding sites, target genes, cell cycle,Abstract
It was studied binding of miRNAs with mRNAs of genes involved in the cell cycle. miRNAs binding with high efficiency with mRNAs of genes involved in the cell cycle were established. miR-619-5p, miR- 1273f, miR-1273g-3p, miR-574-5p, miR-3960, miR-619-5p, miR-1273e, miR-5096 and miR-5095 can bind with mRNA of several genes. Unique miRNAs can dominantly influence on the expression of the essential parts of human protein-coding genes, including cell cycle genes. Multiple binding sites of some miRNAs demonstrate high interaction between them and genes expression. We offer using unique miRNAs as tumorigenesis markers based on the results of the interaction of miRNAs and target genes. The characteristics of the interaction of miRNA with mRNA of the cell cycle genes in lung cancer are discussed.References
1 Wong R.S. Apoptosis in cancer: from pathogenesis to treatment // Journal of Experimental & Clinical Cancer Research. – 2011. – Vol. 30. – P. 87.
2 Jin J., Zhou S., Li C., Xu L., You J., Zhang B. MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression // Life Sciences. – 2014. – Vol. 108(1). – P. 48–53.
3 Kopp F., Wagner E., Roidl A. The proto-oncogene KRAS is targeted by miR-200c // Oncotarget. – 2014. – Vol. 5(1). – P. 185–195.
4 Wang H., Zhu Y. et al. MiRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin в1 and matrix metalloproteinase2 (MMP2) // PLoS One. – 2013. – V.8(8). – e70192.
5 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. Binding sites of miR-1273 family on the mRNA of target genes // BioMed research international. – 2014. – Vol. 2014. – P. 620530.
6 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes // BioMed research international. – 2014. – Vol. 2014. – P. 720715.
7 Berillo O., Régnier M., Ivashchenko A. Binding of intronic microRNAs with mRNAs of genes coding intronic microRNAs and proteins participating in tumourigenesis // Computers in Biology and Medicine. – 2013. – Vol. 43(10). – P. 1374–1381.
8 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. – Vol. 10(7). – P. 423–427.
9 Berillo O., Regnier M., Ivashchenko A.T. miRAFinder and GeneAFinder scripts: large-scale searching for microRNA and related information in indexed literature abstracts // Bioinformation. – 2014. – Vol. 10(8). – P. 539–543.
10 Berillo O., Regnier M., Ivashchenko A.T. TmiRUSite and TmiROSite scripts: searching for mRNA fragments with microRNA binding sites and their encoded for amino acid sequences // Bioinformation. – 2014. – Vol. 10(7). – P. 472–473.
11 Zhao Y., Yu H., Hu W. The regulation of MDM2 oncogene and its impact on human cancers // Acta Biochimica et Biophysica Sinica. – 2014. – Vol. 46(3). – P. 180–189.
12 Kim E.Y., Kim A., Kim S.K., Kim H.J., Chang J., Ahn C.M., Chang Y.S. Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3в signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells // Respiratory Research. – 2014. – Vol. 15. – P. 26.
13 Nomura M., Fukuda T., Fujii K., et al. Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung // An FFPE J Clin proteomic study. Bioinforma. – 2011. – Vol. 1(1). – P. 23.
14 Wu C., Zhu J., Zhang X. Network-based differential gene expression analysis suggests cell cycle related genes regulated by E2F1 underlie the molecular difference between smoker and non-smoker lung adenocarcinoma // BMC Bioinformatics. – 2014. – Vol. 14. – P. 365.
15 Coe B.P., Thu K.L., Aviel-Ronen S., Vucic E.A., Gazdar A.F., Lam S., Tsao M.S., Lam W.L. Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer // Plos One. – 2013. – Vol. 8(8). –e71670.
16 Takahashi T., Obata Y., Sekido Y., et al. Expression and amplification of Myc gene family in small cell lung cancer and its relation to biological characteristics // Cancer research. – 1989. – Vol. 49. – P. 2683–2688.
17 Wu C., Zhu J., Zhang X. Network-based differential gene expression analysis suggests cell cycle related genes regulated by E2F1 underlie the molecular difference between smoker and non-smoker lung adenocarcinoma // BMC Bioinformatics. – 2013. – Vol. 17, N. 14. – P. 365.
18 Taniwaki M., Daigo Y., Ishikawa N., et al. Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer // International Journal of Oncology. – 2006. – Vol. 29. – P. 567–575.
19 Nijazova R.E., Berillo O.A., Atambaeva Sh.A., Ivashhenko A.T. Svojstva miRNA, specifichnyh dlja genov, uchastvujushhih v razvitii melkokletochnogo raka legkogo // Izvestija NAN RK. – 2014. – №5.
20 Wang S.A., Hung C.Y., Chuang J.Y., Chang W.C., Hsu T.I., Hung J.J. Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression // Biochimica et Biophysica Acta. – 2014. – Vol. 1843(6). – P. 1135–1149.
21 Li Q., Li X., Guo Z., et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer // Plos One. – 2012. – Vol. 7(11). – e48278.
22 Chen T.J., Lee S.W., Lin L.C., Lin C.Y., Chang K.Y., Li C.F. Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma // Tumour Biology. – 2014. – Vol. 35(7). – P. 7209–7216.
23 Grabauskiene S., Bergeron E.J., Chen G., Chang A.C., Lin J., Thomas D.G., Giordano T.J., Beer D.G., Morgan M.A., Reddy R.M. CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells // Lung Cancer. – 2013. – Vol. 82(3). – P. 477–484.
2 Jin J., Zhou S., Li C., Xu L., You J., Zhang B. MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression // Life Sciences. – 2014. – Vol. 108(1). – P. 48–53.
3 Kopp F., Wagner E., Roidl A. The proto-oncogene KRAS is targeted by miR-200c // Oncotarget. – 2014. – Vol. 5(1). – P. 185–195.
4 Wang H., Zhu Y. et al. MiRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin в1 and matrix metalloproteinase2 (MMP2) // PLoS One. – 2013. – V.8(8). – e70192.
5 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. Binding sites of miR-1273 family on the mRNA of target genes // BioMed research international. – 2014. – Vol. 2014. – P. 620530.
6 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes // BioMed research international. – 2014. – Vol. 2014. – P. 720715.
7 Berillo O., Régnier M., Ivashchenko A. Binding of intronic microRNAs with mRNAs of genes coding intronic microRNAs and proteins participating in tumourigenesis // Computers in Biology and Medicine. – 2013. – Vol. 43(10). – P. 1374–1381.
8 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. – Vol. 10(7). – P. 423–427.
9 Berillo O., Regnier M., Ivashchenko A.T. miRAFinder and GeneAFinder scripts: large-scale searching for microRNA and related information in indexed literature abstracts // Bioinformation. – 2014. – Vol. 10(8). – P. 539–543.
10 Berillo O., Regnier M., Ivashchenko A.T. TmiRUSite and TmiROSite scripts: searching for mRNA fragments with microRNA binding sites and their encoded for amino acid sequences // Bioinformation. – 2014. – Vol. 10(7). – P. 472–473.
11 Zhao Y., Yu H., Hu W. The regulation of MDM2 oncogene and its impact on human cancers // Acta Biochimica et Biophysica Sinica. – 2014. – Vol. 46(3). – P. 180–189.
12 Kim E.Y., Kim A., Kim S.K., Kim H.J., Chang J., Ahn C.M., Chang Y.S. Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3в signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells // Respiratory Research. – 2014. – Vol. 15. – P. 26.
13 Nomura M., Fukuda T., Fujii K., et al. Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung // An FFPE J Clin proteomic study. Bioinforma. – 2011. – Vol. 1(1). – P. 23.
14 Wu C., Zhu J., Zhang X. Network-based differential gene expression analysis suggests cell cycle related genes regulated by E2F1 underlie the molecular difference between smoker and non-smoker lung adenocarcinoma // BMC Bioinformatics. – 2014. – Vol. 14. – P. 365.
15 Coe B.P., Thu K.L., Aviel-Ronen S., Vucic E.A., Gazdar A.F., Lam S., Tsao M.S., Lam W.L. Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer // Plos One. – 2013. – Vol. 8(8). –e71670.
16 Takahashi T., Obata Y., Sekido Y., et al. Expression and amplification of Myc gene family in small cell lung cancer and its relation to biological characteristics // Cancer research. – 1989. – Vol. 49. – P. 2683–2688.
17 Wu C., Zhu J., Zhang X. Network-based differential gene expression analysis suggests cell cycle related genes regulated by E2F1 underlie the molecular difference between smoker and non-smoker lung adenocarcinoma // BMC Bioinformatics. – 2013. – Vol. 17, N. 14. – P. 365.
18 Taniwaki M., Daigo Y., Ishikawa N., et al. Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer // International Journal of Oncology. – 2006. – Vol. 29. – P. 567–575.
19 Nijazova R.E., Berillo O.A., Atambaeva Sh.A., Ivashhenko A.T. Svojstva miRNA, specifichnyh dlja genov, uchastvujushhih v razvitii melkokletochnogo raka legkogo // Izvestija NAN RK. – 2014. – №5.
20 Wang S.A., Hung C.Y., Chuang J.Y., Chang W.C., Hsu T.I., Hung J.J. Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression // Biochimica et Biophysica Acta. – 2014. – Vol. 1843(6). – P. 1135–1149.
21 Li Q., Li X., Guo Z., et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer // Plos One. – 2012. – Vol. 7(11). – e48278.
22 Chen T.J., Lee S.W., Lin L.C., Lin C.Y., Chang K.Y., Li C.F. Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma // Tumour Biology. – 2014. – Vol. 35(7). – P. 7209–7216.
23 Grabauskiene S., Bergeron E.J., Chen G., Chang A.C., Lin J., Thomas D.G., Giordano T.J., Beer D.G., Morgan M.A., Reddy R.M. CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells // Lung Cancer. – 2013. – Vol. 82(3). – P. 477–484.
Downloads
How to Cite
Ivashchenko, A. T., Berillo, O. A., Niyazova, R. Y., & Shylmyrzayeva, A. K. (2015). The interaction of miRNA with mRNA of the cell cycle genes in lung cancer. Experimental Biology, 62(3), 9–15. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/196
Issue
Section
BIOTECHNOLOGY
