Взаимодействие miRNA с mRNA генов клеточного цикла при раке легкого. Өкпе обыры кезінде miRNA-дың жасушалық циклдің гендерінің mRNA-мен байланысуы
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Кілттік сөздер:
miRNA, mRNA, сайты связывания, гены- мишени, клеточный цикл, байланысу сайттар, нысана гендер, жасушалық цик,Аннотация
Изучено связывание miRNA с mRNA генов, участвующих в клеточном цикле. Установлены miRNA, связывающиеся с высокой эффективностью с mRNA генов, участвующих в клеточном цикле. miR-619-5p, miR-1273f, miR-1273g-3p, miR-574-5p, miR-3960, miR-619-5p, miR-1273e, miR-5096 и miR-5095 могут связываться с mRNA нескольких генов. Уникальные miRNA могут оказывать доминирующее влияние на экспрессию существенной частибелок-кодирующих генов человека, в том числе на экспрессию генов клеточного цикла. Жасушалық циклге қатысатын гендердің mRNAмен miRNAдың байланысуы зерттелген. Жасушалық циклге қатысатын гендердің mRNA-мен жоғары эффективтілігімен байланысатын miRNAлар анықталған. miR-619-5p, miR-1273f, miR-1273g-3p, miR-574-5p, miR-3960, miR-619-5p, miR-1273e, miR-5096 және miR-5095 бірнеше гендердің mRNAмен байланыса алады.Библиографиялық сілтемелер
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20 Wang S.A., Hung C.Y., Chuang J.Y., Chang W.C., Hsu T.I., Hung J.J. Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression // Biochimica et Biophysica Acta. – 2014. – Vol. 1843(6). – P. 1135–1149.
21 Li Q., Li X., Guo Z., et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer // Plos One. – 2012. – Vol. 7(11). – e48278.
22 Chen T.J., Lee S.W., Lin L.C., Lin C.Y., Chang K.Y., Li C.F. Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma // Tumour Biology. – 2014. – Vol. 35(7). – P. 7209–7216.
23 Grabauskiene S., Bergeron E.J., Chen G., Chang A.C., Lin J., Thomas D.G., Giordano T.J., Beer D.G., Morgan M.A., Reddy R.M. CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells // Lung Cancer. – 2013. – Vol. 82(3). – P. 477–484.
2 Jin J., Zhou S., Li C., Xu L., You J., Zhang B. MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression // Life Sciences. – 2014. – Vol. 108(1). – P. 48–53.
3 Kopp F., Wagner E., Roidl A. The proto-oncogene KRAS is targeted by miR-200c // Oncotarget. – 2014. – Vol. 5(1). – P. 185–195.
4 Wang H., Zhu Y. et al. MiRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin в1 and matrix metalloproteinase2 (MMP2) // PLoS One. – 2013. – V.8(8). – e70192.
5 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. Binding sites of miR-1273 family on the mRNA of target genes // BioMed research international. – 2014. – Vol. 2014. – P. 620530.
6 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes // BioMed research international. – 2014. – Vol. 2014. – P. 720715.
7 Berillo O., Régnier M., Ivashchenko A. Binding of intronic microRNAs with mRNAs of genes coding intronic microRNAs and proteins participating in tumourigenesis // Computers in Biology and Medicine. – 2013. – Vol. 43(10). – P. 1374–1381.
8 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. – Vol. 10(7). – P. 423–427.
9 Berillo O., Regnier M., Ivashchenko A.T. miRAFinder and GeneAFinder scripts: large-scale searching for microRNA and related information in indexed literature abstracts // Bioinformation. – 2014. – Vol. 10(8). – P. 539–543.
10 Berillo O., Regnier M., Ivashchenko A.T. TmiRUSite and TmiROSite scripts: searching for mRNA fragments with microRNA binding sites and their encoded for amino acid sequences // Bioinformation. – 2014. – Vol. 10(7). – P. 472–473.
11 Zhao Y., Yu H., Hu W. The regulation of MDM2 oncogene and its impact on human cancers // Acta Biochimica et Biophysica Sinica. – 2014. – Vol. 46(3). – P. 180–189.
12 Kim E.Y., Kim A., Kim S.K., Kim H.J., Chang J., Ahn C.M., Chang Y.S. Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3в signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells // Respiratory Research. – 2014. – Vol. 15. – P. 26.
13 Nomura M., Fukuda T., Fujii K., et al. Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung // An FFPE J Clin proteomic study. Bioinforma. – 2011. – Vol. 1(1). – P. 23.
14 Wu C., Zhu J., Zhang X. Network-based differential gene expression analysis suggests cell cycle related genes regulated by E2F1 underlie the molecular difference between smoker and non-smoker lung adenocarcinoma // BMC Bioinformatics. – 2014. – Vol. 14. – P. 365.
15 Coe B.P., Thu K.L., Aviel-Ronen S., Vucic E.A., Gazdar A.F., Lam S., Tsao M.S., Lam W.L. Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer // Plos One. – 2013. – Vol. 8(8). –e71670.
16 Takahashi T., Obata Y., Sekido Y., et al. Expression and amplification of Myc gene family in small cell lung cancer and its relation to biological characteristics // Cancer research. – 1989. – Vol. 49. – P. 2683–2688.
17 Wu C., Zhu J., Zhang X. Network-based differential gene expression analysis suggests cell cycle related genes regulated by E2F1 underlie the molecular difference between smoker and non-smoker lung adenocarcinoma // BMC Bioinformatics. – 2013. – Vol. 17, N. 14. – P. 365.
18 Taniwaki M., Daigo Y., Ishikawa N., et al. Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer // International Journal of Oncology. – 2006. – Vol. 29. – P. 567–575.
19 Nijazova R.E., Berillo O.A., Atambaeva Sh.A., Ivashhenko A.T. Svojstva miRNA, specifichnyh dlja genov, uchastvujushhih v razvitii melkokletochnogo raka legkogo // Izvestija NAN RK. – 2014. – №5.
20 Wang S.A., Hung C.Y., Chuang J.Y., Chang W.C., Hsu T.I., Hung J.J. Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression // Biochimica et Biophysica Acta. – 2014. – Vol. 1843(6). – P. 1135–1149.
21 Li Q., Li X., Guo Z., et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer // Plos One. – 2012. – Vol. 7(11). – e48278.
22 Chen T.J., Lee S.W., Lin L.C., Lin C.Y., Chang K.Y., Li C.F. Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma // Tumour Biology. – 2014. – Vol. 35(7). – P. 7209–7216.
23 Grabauskiene S., Bergeron E.J., Chen G., Chang A.C., Lin J., Thomas D.G., Giordano T.J., Beer D.G., Morgan M.A., Reddy R.M. CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells // Lung Cancer. – 2013. – Vol. 82(3). – P. 477–484.
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Ivashchenko, A. T., Berillo, O. A., Niyazova, R. Y., & Shylmyrzayeva, A. K. (2015). Взаимодействие miRNA с mRNA генов клеточного цикла при раке легкого. Өкпе обыры кезінде miRNA-дың жасушалық циклдің гендерінің mRNA-мен байланысуы. ҚазҰУ Хабаршысы. Биология сериясы, 62(3), 9–15. вилучено із https://bb.kaznu.kz/index.php/biology/article/view/196
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