Characteristics of miRNA interaction with mRNA in 5'UTR, CDS and 3'UTR of candidate genes of esophageal and stomach cancer
DOI:
https://doi.org/10.26577/eb-2018-3-1339Аннотация
miRNAs demonstrate a class of small, non-coding RNAs that can regulate the expression of genes, and are associated with approximately all known physiological and pathological processes, especially cancer. Expression of many genes is regulated by binding of miRNA with mRNA, therefore it is required to identify candidate genes of esophageal and stomach cancers and to what extent they can interact with miRNA. To determine the important miRNAs biding sites in genes, involved in the development of esophageal and stomach cancers, there were used the MirTarget program. The article presents the results of studying the characteristics of the interaction of miRNAs with mRNAs of 121 genes involved in the development of esophageal and stomach cancer. From the 68 candidate genes, participating in the development of esophageal cancer, only 54 genes were targets for miRNAs. 148 miRNAs have binding sites at 5'UTR, CDS, and 3'UTR, and the average free binding energy (ΔG) of miRNAs with mRNAs was -126 kJ/mole, -121 kJ/mole and -111kJ/mole, respectively. 20 miRNAs and mRNA genes associations with a free energy of interaction more than -125 kJ/mole are recommended for the diagnosis of esophageal cancer. From the 106 candidate genes, participating in the development of stomach cancer, 86 genes were targets for miRNAs. 253 miRNAs have binding sites at 5'UTR, CDS and 3'UTR and the average free binding energy (ΔG) of miRNAs with mRNAs was -124 kJ/mole, -116 kJ/mole and -110 kJ/mole, respectively. 28 miRNAs associations with mRNAs are recommended for the diagnosis of stomach cancer that have a free energy of interaction more than -125 kJ/mole. The mRNAs of most genes containing two or more miRNA binding sites with overlapping of their nucleotide sequences form clusters. Based on the obtained results, groups of miRNA and mRNA associations of candidate genes are recommended to develop methods for early diagnosis of esophageal and stomach cancer. The 768 previously unreported binding sites for 3071 miRNAs, which may be the main ones in the regulation of genes responsible for the development of esophageal and stomach cancers was established.
Key words: mRNA, miRNA, genes, oncological diseases, esophageal cancer, stomach cancer.
Библиографиялық сілтемелер
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Bartel D.P. MicroRNAs: Target Recognition and Regulatory Functions // Cell. - 2009. - Vol. 136. - P. 215-233. DOI: https://doi.org/10.1016/j.
Cipolla G.A. A non-canonical landscape of the microRNA system // Frontiers in Genetics. - 2014. - Vol. 5. - P. 1-6. doi: 10.3389/fgene.2014.00337
Naeli P., Azad F. M., Malakootian Ma., Seidah N.G., Mowla S.J. Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224 // Frontiers in Genetics. - 2017. - Vol. 8. - P. 1-7. doi: 10.3389/fgene.2017.00189
Syngal S., Brand R.E., Church J.M., Giardiello F. M., Hampel H. L., Burt R.W. ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes // Am J Gastroenterol. - 2015. - Vol. 110. - P. 223-262.
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Mathé E.A., Nguyen G.H., Bowman E.D., Zhao Y., Budhu A., Schetter A.J., Braun R., Reimers M., Kumamoto K., Hughes D., et al. MiRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: Associations with survival // Clin Cancer Res. - 2009. - Vol. 15. - P. 6192-6200.
Zeng H., Zheng R., Zhang S., Zuo T., Xia C., Zou X., Chen W. Esophageal cancer statistics in China, 2011: Estimates based on 177 cancer registries // Thorac Cancer. - 2016. - Vol. 7. - P. 232–237. doi: 10.1111/1759-7714.12322.
Rustgi A.K., El-Serag H.B. Esophageal Carcinoma // New Engl J Med. - 2014. - Vol. 371. - P. 2499-509. 10.1056/NEJMra1314530
Lin L.L., Huang H.C., Juan H.F. Discovery of biomarkers for gastric cancer: a proteomics approach // J. Proteom. - 2012. - Vol. 75. - P. 3081-3097.
el-Rifai W.P.S. Molecular and biologic basis of upper gastrointestinal malignancy. Gastric carcinoma // SurgOncolClin N Am. - 2002. - Vol. 11. - P. 273-91.
Fornaro L., Vasile E., Aprile G., Goetze T.O., Vivaldi C., Falcone A., Al-Batran S.E. Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions // Cancer Treat Rev. - 2018. - Vol. 69. - P. 90-100. doi: 10.1016/j.ctrv.2018.06.012.
Jamali L., Tofigh R., Tutunchi S., Panahi G., Borhani F., Akhavan S., Nourmohammadi P., Ghaderian S.M., Rasouli M., Mirzaei H. Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers // J Cell Physiol. - 2018. doi: 10.1002/jcp.26850.
Abbas M., Faggian A., Sintali D.N., Khan G.J., Naeem S., Shi M., Dingding C. Current and future biomarkers in gastric cancer // Biomed Pharmacother. - 2018. - Vol.103. - P. 1688-1700. doi: 10.1016/j.biopha.2018.04.178.
Garofalo M., Croce C.M. microRNAs: Master regulators as potential therapeutics in cancer // Annu Rev Pharmacol Toxicol. - 2011. - Vol. 51. - P. 25–43.
Zhou Y., Li R., Yu H., Wang R., Shen Z. microRNA-130a is an oncomir suppressing the expression of CRMP4 in gastric cancer // Onco Targets Ther. - 2017. - Vol. 10. - P. 3893-3905. doi: 10.2147/OTT.S139443.
Wang Z., Zhao Z., Yang Y., Luo M., Zhang M., Wang X., Liu L., Hou N., Guo Q., Song T., Guo B., Huang C. MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer // Sci Rep. - 2018. - Vol. 8(1). - P. 10119. doi: 10.1038/s41598-018-27583-y.
Feng C., Xian Q., Liu S. Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2 // Biomed Pharmacother. - 2018. - Vol. 97. - P. 1595-1602. doi: 10.1016/j.biopha.2017.11.091.
Chen M., Xia Y., Tan Y., Jiang G., Jin H., Chen Y. Downregulation of microRNA-370 in esophageal squamous-cell carcinoma is associated with cancer progression and promotes cancer cell proliferation via upregulating PIN1 // Gene. - 2018. - Vol. 661. - P. 68-77. doi: 10.1016/j.gene.2018.03.090.
Cao W., Wei W., Zhan Z., Xie D., Xie Y., Xiao Q. Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis // Int J Mol Med. - 2018. - Vol. 41(4). - P. 1958-1966. doi: 10.3892/ijmm.2018.3381.
Guanen Q., Junjie S., Baolin W., Chaoyang W., Yajuan Y., Jing L., Junpeng L., Gaili N., Zhongping W., Jun W. MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway // Biomed Pharmacother. - 2018. - Vol. 105. - P. 350-361. doi: 10.1016/j.biopha.2018.05.149.
Berillo O., Régnier M., Ivashchenko A. Binding of intronic miRNAs with mRNAs of genes coding intronic microRNAs and proteins participating in tumourigenesis // Computers in Biology and Medicine. - 2013. - Vol. 43, № 10. - P. 1374-1381.
Londin E., Lohera P., Telonisa A.G., Quanna K., et al. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs // PNAS USA. - 2015. - Vol. 112, No. 10. - P. 1106-1115.
Kool E.T. Hydrogen bonding, base stacking, and steric effects in DNA replication // Annual Review of Biophysics and Biomolecular Structure. - 2001. - Vol. 30. - P. 1–22.
Leontis N.B., Stombaugh J., Westhof E. The non-Watson-Crick base pairs and their associated isostericity matrices // Nucleic Acids Research. - 2002. - Vol. 30, No. 16. - P. 3497–3531.
References
Abbas M., Faggian A., Sintali D.N., Khan G.J., Naeem S., Shi M., Dingding C. (2018) Current and future biomarkers in gastric cancer. Biomed Pharmacother., vol.103, pp. 1688-1700. doi: 10.1016/j.biopha.2018.04.178.
Bartel D.P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, vol. 116, pp. 281-97.
Bartel D.P. (2009) MicroRNAs: Target Recognition and Regulatory Functions. Cell, vol. 136, p. 215-233. doi: https://doi.org/10.1016/j.
Berillo O., Régnier M., Ivashchenko A. (2013) Binding of intronic miRNAs with mRNAs of genes coding intronic microRNAs and proteins participating in tumourigenesis. Computers in Biology and Medicine, vol. 43, no. 10, pp. 1374-1381.
Cao W., Wei W., Zhan Z., Xie D., Xie Y., Xiao Q. (2018) Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis. Int J Mol Med., vol. 41(4), pp. 1958-1966. doi: 10.3892/ijmm.2018.3381.
Chen M., Xia Y., Tan Y., Jiang G., Jin H., Chen Y. (2018) Downregulation of microRNA-370 in esophageal squamous-cell carcinoma is associated with cancer progression and promotes cancer cell proliferation via upregulating PIN1. Gene, vol. 661, pp. 68-77. doi: 10.1016/j.gene.2018.03.090.
Cipolla G.A. (2014) A non-canonical landscape of the microRNA system. Front Genet., vol. 5, p. 1-6. doi: 10.3389/fgene.2014.00337.
el-Rifai W.P.S. (2002) Molecular and biologic basis of upper gastrointestinal malignancy. Gastric carcinoma. SurgOncolClin N Am., vol. 11, pp. 273-91.
Feng C., Xian Q., Liu S. (2018) Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2. Biomed Pharmacother., vol. 97, pp. 1595-1602. doi: 10.1016/j.biopha.2017.11.091.
Fornaro L., Vasile E., Aprile G., Goetze T.O., Vivaldi C., Falcone A., Al-Batran S.E. (2018) Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions. Cancer Treat Rev., vol. 69, pp. 90-100. doi: 10.1016/j.ctrv.2018.06.012.
Garofalo M., Croce C.M. (2011) microRNAs: Master regulators as potential therapeutics in cancer. Annu Rev Pharmacol Toxicol., vol. 51, pp. 25–43.
Guanen Q., Junjie S., Baolin W., Chaoyang W., Yajuan Y., Jing L., Junpeng L., Gaili N., Zhongping W., Jun W. (2018) MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway. Biomed Pharmacother., vol. 105, pp. 350-361. doi: 10.1016/j.biopha.2018.05.149.
Jamali L., Tofigh R., Tutunchi S., Panahi G., Borhani F., Akhavan S., Nourmohammadi P., Ghaderian S.M., Rasouli M., Mirzaei H. (2018) Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers. J Cell Physiol. doi: 10.1002/jcp.26850.
Kool E.T. (2001) Hydrogen bonding, base stacking, and steric effects in DNA replication. Annual Review of Biophysics and Biomolecular Structure, vol. 30, pp. 1–22.
Leontis N.B., Stombaugh J., Westhof E. (2002) The non-Watson-Crick base pairs and their associated isostericity matrices. Nucleic Acids Research, vol. 30, no. 16, pp. 3497–3531.
Lin L.L., Huang H.C., Juan H.F. (2012) Discovery of biomarkers for gastric cancer: a proteomics approach. J. Proteom., vol. 75, pp. 3081-3097.
Londin E., Lohera P., Telonisa A.G., Quanna K., et al. (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. PNAS USA, vol. 112, no. 10, pp. 1106-1115.
Mathé E.A., Nguyen G.H., Bowman E.D., Zhao Y., Budhu A., Schetter A.J., Braun R., Reimers M., Kumamoto K., Hughes D., et al. (2009) MiRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: Associations with survival. Clin Cancer Res., vol. 15, pp. 6192-6200.
Naeli P., Azad F. M., Malakootian Ma., Seidah N.G., Mowla S.J. (2017) Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224. Front Genet., vol. 8, pp. 1-7. doi: 10.3389/fgene.2017.00189.
Rustgi A.K., El-Serag H.B. (2014) Esophageal Carcinoma. New Engl J Med., vol. 371, pp. 2499-509. 10.1056/NEJMra1314530
Syngal S., Brand R.E., Church J.M., Giardiello F. M., Hampel H. L., Burt R.W. (2015) ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes. Am J Gastroenterol., vol. 110, pp. 223-262.
Torre L.A., Bray F., Siegel R.L., Ferlay J., Lortet-Tieulent J., Jemal A. (2015) Global cancer statistics, 2012. CA Cancer J Clin., vol. 65, pp. 87–108. doi: 10.3322/caac.21262.
Wang Z., Zhao Z., Yang Y., Luo M., Zhang M., Wang X., Liu L., Hou N., Guo Q., Song T., Guo B., Huang C. (2018) MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer. Sci Rep., vol. 8(1), pp. 10119. doi: 10.1038/s41598-018-27583-y.
Zeng H., Zheng R., Zhang S., Zuo T., Xia C., Zou X., Chen W. (2016) Esophageal cancer statistics in China, 2011: Estimates based on 177 cancer registries. Thorac Cancer, vol. 7, pp. 232–237. doi: 10.1111/1759-7714.12322.
Zhou Y., Li R., Yu H., Wang R., Shen Z. (2017) microRNA-130a is an oncomir suppressing the expression of CRMP4 in gastric cancer. Onco Targets Ther., vol. 10, pp. 3893-3905. doi: 10.2147/OTT.S139443.
Bartel D.P. MicroRNAs: Target Recognition and Regulatory Functions // Cell. - 2009. - Vol. 136. - P. 215-233. DOI: https://doi.org/10.1016/j.
Cipolla G.A. A non-canonical landscape of the microRNA system // Frontiers in Genetics. - 2014. - Vol. 5. - P. 1-6. doi: 10.3389/fgene.2014.00337
Naeli P., Azad F. M., Malakootian Ma., Seidah N.G., Mowla S.J. Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224 // Frontiers in Genetics. - 2017. - Vol. 8. - P. 1-7. doi: 10.3389/fgene.2017.00189
Syngal S., Brand R.E., Church J.M., Giardiello F. M., Hampel H. L., Burt R.W. ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes // Am J Gastroenterol. - 2015. - Vol. 110. - P. 223-262.
Torre L.A., Bray F., Siegel R.L., Ferlay J., Lortet-Tieulent J., Jemal A. Global cancer statistics, 2012 // CA Cancer J Clin. - 2015. - Vol. 65. - P. 87–108. doi: 10.3322/caac.21262.
Mathé E.A., Nguyen G.H., Bowman E.D., Zhao Y., Budhu A., Schetter A.J., Braun R., Reimers M., Kumamoto K., Hughes D., et al. MiRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: Associations with survival // Clin Cancer Res. - 2009. - Vol. 15. - P. 6192-6200.
Zeng H., Zheng R., Zhang S., Zuo T., Xia C., Zou X., Chen W. Esophageal cancer statistics in China, 2011: Estimates based on 177 cancer registries // Thorac Cancer. - 2016. - Vol. 7. - P. 232–237. doi: 10.1111/1759-7714.12322.
Rustgi A.K., El-Serag H.B. Esophageal Carcinoma // New Engl J Med. - 2014. - Vol. 371. - P. 2499-509. 10.1056/NEJMra1314530
Lin L.L., Huang H.C., Juan H.F. Discovery of biomarkers for gastric cancer: a proteomics approach // J. Proteom. - 2012. - Vol. 75. - P. 3081-3097.
el-Rifai W.P.S. Molecular and biologic basis of upper gastrointestinal malignancy. Gastric carcinoma // SurgOncolClin N Am. - 2002. - Vol. 11. - P. 273-91.
Fornaro L., Vasile E., Aprile G., Goetze T.O., Vivaldi C., Falcone A., Al-Batran S.E. Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions // Cancer Treat Rev. - 2018. - Vol. 69. - P. 90-100. doi: 10.1016/j.ctrv.2018.06.012.
Jamali L., Tofigh R., Tutunchi S., Panahi G., Borhani F., Akhavan S., Nourmohammadi P., Ghaderian S.M., Rasouli M., Mirzaei H. Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers // J Cell Physiol. - 2018. doi: 10.1002/jcp.26850.
Abbas M., Faggian A., Sintali D.N., Khan G.J., Naeem S., Shi M., Dingding C. Current and future biomarkers in gastric cancer // Biomed Pharmacother. - 2018. - Vol.103. - P. 1688-1700. doi: 10.1016/j.biopha.2018.04.178.
Garofalo M., Croce C.M. microRNAs: Master regulators as potential therapeutics in cancer // Annu Rev Pharmacol Toxicol. - 2011. - Vol. 51. - P. 25–43.
Zhou Y., Li R., Yu H., Wang R., Shen Z. microRNA-130a is an oncomir suppressing the expression of CRMP4 in gastric cancer // Onco Targets Ther. - 2017. - Vol. 10. - P. 3893-3905. doi: 10.2147/OTT.S139443.
Wang Z., Zhao Z., Yang Y., Luo M., Zhang M., Wang X., Liu L., Hou N., Guo Q., Song T., Guo B., Huang C. MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer // Sci Rep. - 2018. - Vol. 8(1). - P. 10119. doi: 10.1038/s41598-018-27583-y.
Feng C., Xian Q., Liu S. Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2 // Biomed Pharmacother. - 2018. - Vol. 97. - P. 1595-1602. doi: 10.1016/j.biopha.2017.11.091.
Chen M., Xia Y., Tan Y., Jiang G., Jin H., Chen Y. Downregulation of microRNA-370 in esophageal squamous-cell carcinoma is associated with cancer progression and promotes cancer cell proliferation via upregulating PIN1 // Gene. - 2018. - Vol. 661. - P. 68-77. doi: 10.1016/j.gene.2018.03.090.
Cao W., Wei W., Zhan Z., Xie D., Xie Y., Xiao Q. Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis // Int J Mol Med. - 2018. - Vol. 41(4). - P. 1958-1966. doi: 10.3892/ijmm.2018.3381.
Guanen Q., Junjie S., Baolin W., Chaoyang W., Yajuan Y., Jing L., Junpeng L., Gaili N., Zhongping W., Jun W. MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway // Biomed Pharmacother. - 2018. - Vol. 105. - P. 350-361. doi: 10.1016/j.biopha.2018.05.149.
Berillo O., Régnier M., Ivashchenko A. Binding of intronic miRNAs with mRNAs of genes coding intronic microRNAs and proteins participating in tumourigenesis // Computers in Biology and Medicine. - 2013. - Vol. 43, № 10. - P. 1374-1381.
Londin E., Lohera P., Telonisa A.G., Quanna K., et al. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs // PNAS USA. - 2015. - Vol. 112, No. 10. - P. 1106-1115.
Kool E.T. Hydrogen bonding, base stacking, and steric effects in DNA replication // Annual Review of Biophysics and Biomolecular Structure. - 2001. - Vol. 30. - P. 1–22.
Leontis N.B., Stombaugh J., Westhof E. The non-Watson-Crick base pairs and their associated isostericity matrices // Nucleic Acids Research. - 2002. - Vol. 30, No. 16. - P. 3497–3531.
References
Abbas M., Faggian A., Sintali D.N., Khan G.J., Naeem S., Shi M., Dingding C. (2018) Current and future biomarkers in gastric cancer. Biomed Pharmacother., vol.103, pp. 1688-1700. doi: 10.1016/j.biopha.2018.04.178.
Bartel D.P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, vol. 116, pp. 281-97.
Bartel D.P. (2009) MicroRNAs: Target Recognition and Regulatory Functions. Cell, vol. 136, p. 215-233. doi: https://doi.org/10.1016/j.
Berillo O., Régnier M., Ivashchenko A. (2013) Binding of intronic miRNAs with mRNAs of genes coding intronic microRNAs and proteins participating in tumourigenesis. Computers in Biology and Medicine, vol. 43, no. 10, pp. 1374-1381.
Cao W., Wei W., Zhan Z., Xie D., Xie Y., Xiao Q. (2018) Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis. Int J Mol Med., vol. 41(4), pp. 1958-1966. doi: 10.3892/ijmm.2018.3381.
Chen M., Xia Y., Tan Y., Jiang G., Jin H., Chen Y. (2018) Downregulation of microRNA-370 in esophageal squamous-cell carcinoma is associated with cancer progression and promotes cancer cell proliferation via upregulating PIN1. Gene, vol. 661, pp. 68-77. doi: 10.1016/j.gene.2018.03.090.
Cipolla G.A. (2014) A non-canonical landscape of the microRNA system. Front Genet., vol. 5, p. 1-6. doi: 10.3389/fgene.2014.00337.
el-Rifai W.P.S. (2002) Molecular and biologic basis of upper gastrointestinal malignancy. Gastric carcinoma. SurgOncolClin N Am., vol. 11, pp. 273-91.
Feng C., Xian Q., Liu S. (2018) Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2. Biomed Pharmacother., vol. 97, pp. 1595-1602. doi: 10.1016/j.biopha.2017.11.091.
Fornaro L., Vasile E., Aprile G., Goetze T.O., Vivaldi C., Falcone A., Al-Batran S.E. (2018) Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions. Cancer Treat Rev., vol. 69, pp. 90-100. doi: 10.1016/j.ctrv.2018.06.012.
Garofalo M., Croce C.M. (2011) microRNAs: Master regulators as potential therapeutics in cancer. Annu Rev Pharmacol Toxicol., vol. 51, pp. 25–43.
Guanen Q., Junjie S., Baolin W., Chaoyang W., Yajuan Y., Jing L., Junpeng L., Gaili N., Zhongping W., Jun W. (2018) MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway. Biomed Pharmacother., vol. 105, pp. 350-361. doi: 10.1016/j.biopha.2018.05.149.
Jamali L., Tofigh R., Tutunchi S., Panahi G., Borhani F., Akhavan S., Nourmohammadi P., Ghaderian S.M., Rasouli M., Mirzaei H. (2018) Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers. J Cell Physiol. doi: 10.1002/jcp.26850.
Kool E.T. (2001) Hydrogen bonding, base stacking, and steric effects in DNA replication. Annual Review of Biophysics and Biomolecular Structure, vol. 30, pp. 1–22.
Leontis N.B., Stombaugh J., Westhof E. (2002) The non-Watson-Crick base pairs and their associated isostericity matrices. Nucleic Acids Research, vol. 30, no. 16, pp. 3497–3531.
Lin L.L., Huang H.C., Juan H.F. (2012) Discovery of biomarkers for gastric cancer: a proteomics approach. J. Proteom., vol. 75, pp. 3081-3097.
Londin E., Lohera P., Telonisa A.G., Quanna K., et al. (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. PNAS USA, vol. 112, no. 10, pp. 1106-1115.
Mathé E.A., Nguyen G.H., Bowman E.D., Zhao Y., Budhu A., Schetter A.J., Braun R., Reimers M., Kumamoto K., Hughes D., et al. (2009) MiRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: Associations with survival. Clin Cancer Res., vol. 15, pp. 6192-6200.
Naeli P., Azad F. M., Malakootian Ma., Seidah N.G., Mowla S.J. (2017) Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224. Front Genet., vol. 8, pp. 1-7. doi: 10.3389/fgene.2017.00189.
Rustgi A.K., El-Serag H.B. (2014) Esophageal Carcinoma. New Engl J Med., vol. 371, pp. 2499-509. 10.1056/NEJMra1314530
Syngal S., Brand R.E., Church J.M., Giardiello F. M., Hampel H. L., Burt R.W. (2015) ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes. Am J Gastroenterol., vol. 110, pp. 223-262.
Torre L.A., Bray F., Siegel R.L., Ferlay J., Lortet-Tieulent J., Jemal A. (2015) Global cancer statistics, 2012. CA Cancer J Clin., vol. 65, pp. 87–108. doi: 10.3322/caac.21262.
Wang Z., Zhao Z., Yang Y., Luo M., Zhang M., Wang X., Liu L., Hou N., Guo Q., Song T., Guo B., Huang C. (2018) MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer. Sci Rep., vol. 8(1), pp. 10119. doi: 10.1038/s41598-018-27583-y.
Zeng H., Zheng R., Zhang S., Zuo T., Xia C., Zou X., Chen W. (2016) Esophageal cancer statistics in China, 2011: Estimates based on 177 cancer registries. Thorac Cancer, vol. 7, pp. 232–237. doi: 10.1111/1759-7714.12322.
Zhou Y., Li R., Yu H., Wang R., Shen Z. (2017) microRNA-130a is an oncomir suppressing the expression of CRMP4 in gastric cancer. Onco Targets Ther., vol. 10, pp. 3893-3905. doi: 10.2147/OTT.S139443.
Жүктелулер
Жарияланды
2018-11-17
Шығарылым
Бөлім
МОЛЕКУЛЯРНАЯ БИОЛОГИЯ И ГЕНЕТИКА
