The interaction of miRNA with mRNA of apoptosis genes in lung cancer
Keywords:
miRNA, mRNA, binding sites, target genes, apoptosis,Abstract
Binding of miRNAs with mRNAs of genes involved in apoptosis were studied. It has been established that several miRNAs have binding sites with mRNA of a single gene and one miRNA can binds with mRNAs of several genes. These miRNAs are miR-619-5p, miR-1273g-3p, miR-1273h-3p, miR-5096, miR-5095 and miR-5585-5p. Expression of the most of key genes of apoptosis may regulated by using miRNAs. On the basis of miRNAs with mRNAs of genes involved in apoptosis is recommended to use miRNAs acting on the expression of several genes as markers of carcinogenesis. The expression of some miRNAs in different subtypes of lung cancer is correlated with the expression of their target genes. The characteristics of the interaction of miRNAs with mRNAs of genes of apoptosis in lung cancer are discussed.References
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2 Zhang Q., Padi S.K., Tindall D.J., Guo B. Polycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31 // Cell Death & Disease. – 2014. – Vol. 5. – e1486.
3 Otsuka K., Ochiya T. Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways // BioMed Research International. – 2014. – Vol. 2014. – P. 749724.
4 Wan L., Zhu L., Xu J., Lu B., Yang Y., Liu F., Wang Z. MicroRNA-409-3p Functions as a Tumor Suppressor in Human Lung Adenocarcinoma by Targeting c-Met // Cell Physiology and Biochemistry. – 2014. – Vol. 34(4). – P. 1273–1290.
5 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. – Vol. 10(7). – P. 423–427.
6 Berillo O., Regnier M., Ivashchenko A.T. miRAFinder and GeneAFinder scripts: large-scale searching for microRNA and related information in indexed literature abstracts // Bioinformation. – 2014. – Vol. 10(8). – P. 539–543.
7 Berillo O., Regnier M., Ivashchenko A.T. TmiRUSite and TmiROSite scripts: searching for mRNA fragments with microRNA binding sites and their encoded for amino acid sequences // Bioinformation. – 2014. – Vol. 10(7). – P. 472–473.
8 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. Binding sites of miR-1273 family on the mRNA of target genes // BioMed Research International. – 2014. – Vol. 2014. – P. 620530.
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R. and Atambayeva Sh. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes // BioMed Research International. – 2014. – Vol. 2014. – P. 720715.
10 Liu Z.Y., Zhang G.L., Wang M.M., Xiong Y.N., Cui H.Q. MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation // Asian Pacific Journal of Cancer Prevention . – 2011. – Vol. 12(11) – P. 2819–2823.
11 Dang X., Ma A., Yang L., Hu H., Zhu B., Shang D., Chen T., Luo Y. MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells // Cancer Genetics. – 2012. – Vol.205(3) – P. 13–23.
12 Zhang J.G., Guo J.F., Liu D.L., Liu Q., Wang J.J. MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2 // Journal of Thoracic Oncology. – 2011. – Vol. 6(4). – Р. 671–678.
13 Wang R., Wang Z.X., Yang J.S., Pan X., De W., Chen L.B. MicroRNA-451 functions as a tumor suppressor in human nonsmall cell lung cancer by targeting ras-related protein 14 (RAB14) // Oncogene. – 2011. – Vol. 30(23). – Р. 2644–2658.
14 Liu J., Lu K.H., Liu Z.L., Sun M., De W., Wang Z.X. MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1 // BMC Cancer. – 2012. – Vol. 12. – Р. 519.
15 Liu Z.L., Wang H., Liu J., Wang Z.X. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN // Molecular and Cellular Biochemistry. – 2013. – Vol. 372(1–2). – Р. 35–45.
16 Wang H., Li M., Zhang R., Wang Y., Zang W., Ma Y., Zhao G., Zhang G. Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299 // Tumour Biology. – 2013. – Vol. 34(5). – Р. 3101–3109.
17 Liu X.H., Lu K.H., Wang K.M., Sun M., Zhang E.B., Yang J.S., Yin D.D., Liu Z.L., Zhou J., Liu Z.J., De W., Wang Z.X. MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5 // BMC Cancer. – 2012. – Vol. 12. – Р. 348.
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