Characteristics of miRNA interaction with mRNA of candidate genes of the non-small cell lung cancer
DOI:
https://doi.org/10.26577/eb-2018-3-1341Аннотация
Lung cancer is one of the most common malignant diseases. It is expected to involve more than 200 candidate genes in the development of the non-small cell lung cancer (NSCLC). The present study aimed to study the interaction characteristics of the 137 NSCLC candidate genes and miRNAs. The data obtained show that a significant number of genes are targets of two or more mRNAs. The mRNA of some genes contain binding sites for several miRNAs with overlapping nucleotide sequences, which have been termed clusters. The properties of clusters of non-small cell lung cancer genes, containing binding sites of several miRNAs, were studied for the first time. The properties of clusters with a large number of miRNA binding sites in the 5'UTR are considered. The mRNA of CHKA, E2F1, HMGA2, PTEN, HTRA2, ING1, MTA3, SMARCA4, NFATC2 genes contain clusters of binding sites for the largest number of miRNAs. Several clusters are available in the CDS mRNA of CEBPA, NOTCH3, TRIO, LATS2, RB1 and ZBTB7A genes. 32 genes are targets of 49 miRNAs, binding sites of which are localized in the 3'UTR. The CDK6 and IRS1 genes have clusters with the largest number of miRNA binding sites. The AKT1, EMP and HMGA2 genes have clusters of 34 nt, 40 nt and 41 nt in length, respectively, of the binding sites of three miRNAs. Each mRNA of BCAR1, ITGA11, MYLK, PTK6, PXN, SOX2 and SSX2 genes has clusters of the binding sites of two miRNAs. It is assumed that the expression of the examined genes will depend more on the miRNA interacting with mRNA with a higher free binding energy.
Key words: miRNA, mRNA, Non-Small Cell Lung Cancer, target genes.
Библиографиялық сілтемелер
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3. Han S.S., Kim W.J., Hong Y., Hong S.H., Lee S.J., Ryu D.R., Lee W., Cho Y.H., Lee S., Ryu Y.J., Won J.Y., Rhee H., Park J.H., Jang S.J., Lee J.S., Choi C.M., Lee J.C., Lee S.D., Oh Y.M. RNA sequencing identifies novel markers of non-small cell lung cancer // Lung Cancer. - 2014. - Vol. 84, No. 3. - P. 229-35.
4. Ko H.L., Wang Y.S., Fong W.L., Chi M.S., Chi K.H., Kao S.J. Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for lung cancer: A marker phase I trial // Thorac Cancer. - 2014. - Vol. 5, no. 6. - P. 500-8.
5. Liu M., Zhou K., Huang Y., Cao Y. The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway // J Exp Clin Cancer Res. - 2015. - Vol. 34. - P. 121.
6. Zhang F., Zhang X., Meng J., Zhao Y., Liu X., Liu Y., Wang Y., Li Y., Sun Y., Wang Z., Mei Q., Zhang T. ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer // Oncotarget. - 2015. - Vol. 6, No. 18. - P. 16239-52.
7. Choi Y.Y., Lee S.Y., Lee W.K., Jeon H.S., Lee E.B., Lee H.C., Choi J.E., Kang H.G., Lee E.J., Bae E.Y., Yoo S.S., Lee J., Cha S.I., Kim C.H., Kim I.S., Lee M.H., Kim Y.T., Jheon S., Park J.Y. RACK1 is a candidate gene associated with the prognosis of patients with early stage non-small cell lung cancer // Oncotarget. - 2015. - Vol. 6, No. 6. - P. 4451-66.
8. Huang T., Yang J., Cai Y.D. Novel candidate key drivers in the integrative network of genes, microRNAs, methylations, and copy number variations in squamous cell lung carcinoma // Biomed Res Int. - 2015. - Vol. 2015. - P. 358125.
9. Taguchi Y.H., Iwadate M., Umeyama H. SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer // BMC Med Genomics. - 2016. - Suppl 1. - P. 28.
10. Shi Y.X., Yin J.Y., Shen Y., Zhang W., Zhou H.H., Liu Z.Q. Genome-scale analysis identifies NEK2, DLGAP5 and ECT2 as promising diagnostic and prognostic biomarkers in human lung cancer // Sci Rep. - 2017. - Vol. 7, No. 1. - P. 8072.
11. Kim E.K., Kim K.A., Lee C.Y., Shim H.S. The frequency and clinical impact of HER2 alterations in lung adenocarcinoma // PLoS One. - 2017. - Vol. 12, No. 2. - e0171280.
12. Wang K., Li H., Chen R., Zhang Y., Sun X.X., Huang W., Bian H., Chen Z.N. Combination of CALR and PDIA3 is a potential prognostic biomarker for non-small cell lung cancer // Oncotarget. - 2017. - Vol. 8, No. 57. - P. 96945-96957.
13. Mizuno K., Mataki H., Arai T., Okato A., Kamikawaji K., Kumamoto T., Hiraki T., Hatanaka K., Inoue H., Seki N. The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes // J Hum Genet. - 2017. - Vol. 62, No. 7. - P. 671-678.
14. Wang J., Song J., Gao Z., Huo X., Zhang Y., Wang W., Qi J., Zheng S. Analysis of gene expression profiles of non-small cell lung cancer at different stages reveals significantly altered biological functions and candidate genes // Oncol Rep. - 2017. - Vol. 37, No. 3. - P. 1736-1746.
15. Zhang W., Cui Q., Qu W., Ding X., Jiang D., Liu H. TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma // Oncol Rep. - 2018. doi: 10.3892/or.2018.6426. [Epub ahead of print]
16. Ding X., Zhang S., Li X., Feng C., Huang Q., Wang S., Wang S., Xia W., Yang F., Yin R., Xu L., Qiu M., Li M., Wang J. Profiling expression of coding genes, long noncoding RNA, and circular RNA in lung adenocarcinoma by ribosomal RNA-depleted RNA sequencing // FEBS Open Bio. - 2018. - Vol. 8, No. 4. - P. 544-555.
17. Tabbò F., Nottegar A., Guerrera F., Migliore E., Luchini C., Maletta F., Veronese N., Montagna L., Gaudiano M., Di Giacomo F., Filosso P.L., Delsedime L., Ciccone G., Scarpa A., Sapino A., Oliaro A., Ruffini E., Inghirami G., Chilosi M. Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma // Hum Pathol. - 2018. - Vol. 75. - P. 167-178.
18. Ниязова Р.Е., Атамбаева Ш.А., Пыркова А.Ю., Иващенко А.Т. Ассоциации miRNA и mRNA генов, участвующих в развитии немелкоклеточного рака легких // Вестник КазНУ. Серия биологическая. - 2015. - №3. - C. 143 – 148.
19. Londin E., Lohera P., Telonisa A.G., Quanna K., et al. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs // PNAS USA. - 2015. - Vol. 112, No. 10. - P. 1106-1115.
20. Ivashchenko A.T., Pyrkova A.Y., Niyazova R.Y., Alybayeva A., Baskakov K. Prediction of miRNA binding sites in mRNA // Bioinformation. - 2016. - Vol. 12, No. 4. - P. 237-240.
21. Kool E.T. Hydrogen bonding, base stacking, and steric effects in DNA replication // Annual Review of Biophysics and Biomolecular Structure. - 2001. - Vol. 30. - P. 1–22.
22. Leontis N.B., Stombaugh J., Westhof E. The non-Watson- Crick base pairs and their associated isostericity matrices // Nucleic Acids Research. - 2002. - Vol. 30, No. 16. - P. 3497–3531.
References
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2. Ding X., Zhang S., Li X., Feng C., Huang Q., Wang S., Wang S., Xia W., Yang F., Yin R., Xu L., Qiu M., Li M., Wang J. (2018) Profiling expression of coding genes, long noncoding RNA, and circular RNA in lung adenocarcinoma by ribosomal RNA-depleted RNA sequencing. FEBS Open Bio., vol. 8, no. 4, pp. 544-555. doi: 10.1002/2211-5463.12397.
3. Han S.S., Kim W.J., Hong Y., Hong S.H., Lee S.J., Ryu D.R., Lee W., Cho Y.H., Lee S., Ryu Y.J., Won J.Y., Rhee H., Park J.H., Jang S.J., Lee J.S., Choi C.M., Lee J.C., Lee S.D., Oh Y.M. (2014) RNA sequencing identifies novel markers of non-small cell lung cancer. Lung Cancer, vol. 84, no. 3, pp. 229-35. doi: 10.1016/j.lungcan.2014.03.018.
4. Houston K.A., Henley S.J., Li J., White M.C., Richards T.B. (2014) Patterns in lung cancer incidence rates and trends by histologic type in the United States, 2004–2009. Lung Cancer., vol. 86, pp. 22–28. doi: 10.1016/j.lungcan.2014.08.001.
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6. Ivashchenko A.T., Pyrkova A.Y., Niyazova R.Y., Alybayeva A., Baskakov K. (2016) Prediction of miRNA binding sites in mRNA. Bioinformation, vol. 12, no. 4, pp. 237-240.
7. Kim E.K., Kim K.A., Lee C.Y., Shim H.S. (2017) The frequency and clinical impact of HER2 alterations in lung adenocarcinoma. PLoS One, vol. 12, no. 2, e0171280. doi: 10.1371/journal.pone.0171280.
8. Ko H.L., Wang Y.S., Fong W.L., Chi M.S., Chi K.H., Kao S.J. (2014) Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for lung cancer: A marker phase I trial. Thorac Cancer, vol. 5, no. 6, pp. 500-8. doi: 10.1111/1759-7714.12117.
9. Kool E.T. (2001) Hydrogen bonding, base stacking, and steric effects in DNA replication. Annual Review of Biophysics and Biomolecular Structure, vol. 30, pp. 1–22.
10. Leontis N.B., Stombaugh J., Westhof E. (2002) The non-Watson- Crick base pairs and their associated isostericity matrices. Nucleic Acids Research, vol. 30, no. 16, pp. 3497–3531.
11. Liu M., Zhou K., Huang Y., Cao Y. (2015) The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway. J Exp Clin Cancer Res., vol. 34, pp. 121. doi: 10.1186/s13046-015-0235-5.
12. Londin E., Lohera P., Telonisa A.G., Quanna K., et al. (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. PNAS USA, vol. 112, no. 10, pp. 1106-1115.
13. Mizuno K., Mataki H., Arai T., Okato A., Kamikawaji K., Kumamoto T., Hiraki T., Hatanaka K., Inoue H., Seki N. (2017) The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes. J Hum Genet., vol. 62, no. 7, pp. 671-678. doi: 10.1038/jhg.2017.27.
14. Niyazova R.Y., Аtambayeva S.А., Pyrkova А.Y., Ivashchenko A.T. (2015) Assotsiatsii miRNA i mRNA genov, uchastvuyushchih v razvitii nemelkokletochnogo raka legkih [Associations of miRNA and mRNA genes involved in the development of non-small cell lung cancer]. KazNU Bulletin. Biology series, vol. 65, no 3, pp. 143-148.
15. Pao W., Girard N. (2011) New driver mutations in non-small-cell lung cancer. Lancet Oncol., vol. 12, pp. 175–180. doi: 10.1016/S1470-2045(10)70087-5.
16. Shi Y.X., Yin J.Y., Shen Y., Zhang W., Zhou H.H., Liu Z.Q. (2017) Genome-scale analysis identifies NEK2, DLGAP5 and ECT2 as promising diagnostic and prognostic biomarkers in human lung cancer. Sci Rep., vol. 7, no. 1, pp. 8072. doi: 10.1038/s41598-017-08615-5.
17. Tabbò F., Nottegar A., Guerrera F., Migliore E., Luchini C., Maletta F., Veronese N., Montagna L., Gaudiano M., Di Giacomo F., Filosso P.L., Delsedime L., Ciccone G., Scarpa A., Sapino A., Oliaro A., Ruffini E., Inghirami G., Chilosi M. (2018) Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma. Hum Pathol., vol. 75, pp. 167-178. doi: 10.1016/j.humpath.2018.01.017.
18. Taguchi Y.H., Iwadate M., Umeyama H. (2016) SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer. BMC Med Genomics, Suppl 1, pp. 28. doi: 10.1186/s12920-016-0196-3.
19. Wang J., Song J., Gao Z., Huo X., Zhang Y., Wang W., Qi J., Zheng S. (2017) Analysis of gene expression profiles of non-small cell lung cancer at different stages reveals significantly altered biological functions and candidate genes. Oncol Rep., vol. 37, no. 3, pp. 1736-1746. doi: 10.3892/or.2017.5380.
20. Wang K., Li H., Chen R., Zhang Y., Sun X.X., Huang W., Bian H., Chen Z.N. (2017) Combination of CALR and PDIA3 is a potential prognostic biomarker for non-small cell lung cancer. Oncotarget, vol. 8, no. 57, pp. 96945-96957. doi: 10.18632/oncotarget.18547.
21. Zhang F., Zhang X., Meng J., Zhao Y., Liu X., Liu Y., Wang Y., Li Y., Sun Y., Wang Z., Mei Q., Zhang T. (2015) ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer. Oncotarget, vol. 6, no. 18, pp. 16239-52.
22. Zhang W., Cui Q., Qu W., Ding X., Jiang D., Liu H. (2018) TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma. Oncol Rep., doi: 10.3892/or.2018.6426. [Epub ahead of print]
2. Houston K.A., Henley S.J., Li J., White M.C., Richards T.B. Patterns in lung cancer incidence rates and trends by histologic type in the United States, 2004–2009 // Lung Cancer. - 2014. - Vol. 86. - P. 22–28.
3. Han S.S., Kim W.J., Hong Y., Hong S.H., Lee S.J., Ryu D.R., Lee W., Cho Y.H., Lee S., Ryu Y.J., Won J.Y., Rhee H., Park J.H., Jang S.J., Lee J.S., Choi C.M., Lee J.C., Lee S.D., Oh Y.M. RNA sequencing identifies novel markers of non-small cell lung cancer // Lung Cancer. - 2014. - Vol. 84, No. 3. - P. 229-35.
4. Ko H.L., Wang Y.S., Fong W.L., Chi M.S., Chi K.H., Kao S.J. Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for lung cancer: A marker phase I trial // Thorac Cancer. - 2014. - Vol. 5, no. 6. - P. 500-8.
5. Liu M., Zhou K., Huang Y., Cao Y. The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway // J Exp Clin Cancer Res. - 2015. - Vol. 34. - P. 121.
6. Zhang F., Zhang X., Meng J., Zhao Y., Liu X., Liu Y., Wang Y., Li Y., Sun Y., Wang Z., Mei Q., Zhang T. ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer // Oncotarget. - 2015. - Vol. 6, No. 18. - P. 16239-52.
7. Choi Y.Y., Lee S.Y., Lee W.K., Jeon H.S., Lee E.B., Lee H.C., Choi J.E., Kang H.G., Lee E.J., Bae E.Y., Yoo S.S., Lee J., Cha S.I., Kim C.H., Kim I.S., Lee M.H., Kim Y.T., Jheon S., Park J.Y. RACK1 is a candidate gene associated with the prognosis of patients with early stage non-small cell lung cancer // Oncotarget. - 2015. - Vol. 6, No. 6. - P. 4451-66.
8. Huang T., Yang J., Cai Y.D. Novel candidate key drivers in the integrative network of genes, microRNAs, methylations, and copy number variations in squamous cell lung carcinoma // Biomed Res Int. - 2015. - Vol. 2015. - P. 358125.
9. Taguchi Y.H., Iwadate M., Umeyama H. SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer // BMC Med Genomics. - 2016. - Suppl 1. - P. 28.
10. Shi Y.X., Yin J.Y., Shen Y., Zhang W., Zhou H.H., Liu Z.Q. Genome-scale analysis identifies NEK2, DLGAP5 and ECT2 as promising diagnostic and prognostic biomarkers in human lung cancer // Sci Rep. - 2017. - Vol. 7, No. 1. - P. 8072.
11. Kim E.K., Kim K.A., Lee C.Y., Shim H.S. The frequency and clinical impact of HER2 alterations in lung adenocarcinoma // PLoS One. - 2017. - Vol. 12, No. 2. - e0171280.
12. Wang K., Li H., Chen R., Zhang Y., Sun X.X., Huang W., Bian H., Chen Z.N. Combination of CALR and PDIA3 is a potential prognostic biomarker for non-small cell lung cancer // Oncotarget. - 2017. - Vol. 8, No. 57. - P. 96945-96957.
13. Mizuno K., Mataki H., Arai T., Okato A., Kamikawaji K., Kumamoto T., Hiraki T., Hatanaka K., Inoue H., Seki N. The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes // J Hum Genet. - 2017. - Vol. 62, No. 7. - P. 671-678.
14. Wang J., Song J., Gao Z., Huo X., Zhang Y., Wang W., Qi J., Zheng S. Analysis of gene expression profiles of non-small cell lung cancer at different stages reveals significantly altered biological functions and candidate genes // Oncol Rep. - 2017. - Vol. 37, No. 3. - P. 1736-1746.
15. Zhang W., Cui Q., Qu W., Ding X., Jiang D., Liu H. TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma // Oncol Rep. - 2018. doi: 10.3892/or.2018.6426. [Epub ahead of print]
16. Ding X., Zhang S., Li X., Feng C., Huang Q., Wang S., Wang S., Xia W., Yang F., Yin R., Xu L., Qiu M., Li M., Wang J. Profiling expression of coding genes, long noncoding RNA, and circular RNA in lung adenocarcinoma by ribosomal RNA-depleted RNA sequencing // FEBS Open Bio. - 2018. - Vol. 8, No. 4. - P. 544-555.
17. Tabbò F., Nottegar A., Guerrera F., Migliore E., Luchini C., Maletta F., Veronese N., Montagna L., Gaudiano M., Di Giacomo F., Filosso P.L., Delsedime L., Ciccone G., Scarpa A., Sapino A., Oliaro A., Ruffini E., Inghirami G., Chilosi M. Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma // Hum Pathol. - 2018. - Vol. 75. - P. 167-178.
18. Ниязова Р.Е., Атамбаева Ш.А., Пыркова А.Ю., Иващенко А.Т. Ассоциации miRNA и mRNA генов, участвующих в развитии немелкоклеточного рака легких // Вестник КазНУ. Серия биологическая. - 2015. - №3. - C. 143 – 148.
19. Londin E., Lohera P., Telonisa A.G., Quanna K., et al. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs // PNAS USA. - 2015. - Vol. 112, No. 10. - P. 1106-1115.
20. Ivashchenko A.T., Pyrkova A.Y., Niyazova R.Y., Alybayeva A., Baskakov K. Prediction of miRNA binding sites in mRNA // Bioinformation. - 2016. - Vol. 12, No. 4. - P. 237-240.
21. Kool E.T. Hydrogen bonding, base stacking, and steric effects in DNA replication // Annual Review of Biophysics and Biomolecular Structure. - 2001. - Vol. 30. - P. 1–22.
22. Leontis N.B., Stombaugh J., Westhof E. The non-Watson- Crick base pairs and their associated isostericity matrices // Nucleic Acids Research. - 2002. - Vol. 30, No. 16. - P. 3497–3531.
References
1. Choi Y.Y., Lee S.Y., Lee W.K., Jeon H.S., Lee E.B., Lee H.C., Choi J.E., Kang H.G., Lee E.J., Bae E.Y., Yoo S.S., Lee J., Cha S.I., Kim C.H., Kim I.S., Lee M.H., Kim Y.T., Jheon S., Park J.Y. (2015) RACK1 is a candidate gene associated with the prognosis of patients with early stage non-small cell lung cancer. Oncotarget, vol. 6, no. 6, pp. 4451-66.
2. Ding X., Zhang S., Li X., Feng C., Huang Q., Wang S., Wang S., Xia W., Yang F., Yin R., Xu L., Qiu M., Li M., Wang J. (2018) Profiling expression of coding genes, long noncoding RNA, and circular RNA in lung adenocarcinoma by ribosomal RNA-depleted RNA sequencing. FEBS Open Bio., vol. 8, no. 4, pp. 544-555. doi: 10.1002/2211-5463.12397.
3. Han S.S., Kim W.J., Hong Y., Hong S.H., Lee S.J., Ryu D.R., Lee W., Cho Y.H., Lee S., Ryu Y.J., Won J.Y., Rhee H., Park J.H., Jang S.J., Lee J.S., Choi C.M., Lee J.C., Lee S.D., Oh Y.M. (2014) RNA sequencing identifies novel markers of non-small cell lung cancer. Lung Cancer, vol. 84, no. 3, pp. 229-35. doi: 10.1016/j.lungcan.2014.03.018.
4. Houston K.A., Henley S.J., Li J., White M.C., Richards T.B. (2014) Patterns in lung cancer incidence rates and trends by histologic type in the United States, 2004–2009. Lung Cancer., vol. 86, pp. 22–28. doi: 10.1016/j.lungcan.2014.08.001.
5. Huang T., Yang J., Cai Y.D. (2015) Novel candidate key drivers in the integrative network of genes, microRNAs, methylations, and copy number variations in squamous cell lung carcinoma. Biomed Res Int., vol. 2015, pp. 358125. doi: 10.1155/2015/358125.
6. Ivashchenko A.T., Pyrkova A.Y., Niyazova R.Y., Alybayeva A., Baskakov K. (2016) Prediction of miRNA binding sites in mRNA. Bioinformation, vol. 12, no. 4, pp. 237-240.
7. Kim E.K., Kim K.A., Lee C.Y., Shim H.S. (2017) The frequency and clinical impact of HER2 alterations in lung adenocarcinoma. PLoS One, vol. 12, no. 2, e0171280. doi: 10.1371/journal.pone.0171280.
8. Ko H.L., Wang Y.S., Fong W.L., Chi M.S., Chi K.H., Kao S.J. (2014) Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for lung cancer: A marker phase I trial. Thorac Cancer, vol. 5, no. 6, pp. 500-8. doi: 10.1111/1759-7714.12117.
9. Kool E.T. (2001) Hydrogen bonding, base stacking, and steric effects in DNA replication. Annual Review of Biophysics and Biomolecular Structure, vol. 30, pp. 1–22.
10. Leontis N.B., Stombaugh J., Westhof E. (2002) The non-Watson- Crick base pairs and their associated isostericity matrices. Nucleic Acids Research, vol. 30, no. 16, pp. 3497–3531.
11. Liu M., Zhou K., Huang Y., Cao Y. (2015) The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway. J Exp Clin Cancer Res., vol. 34, pp. 121. doi: 10.1186/s13046-015-0235-5.
12. Londin E., Lohera P., Telonisa A.G., Quanna K., et al. (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. PNAS USA, vol. 112, no. 10, pp. 1106-1115.
13. Mizuno K., Mataki H., Arai T., Okato A., Kamikawaji K., Kumamoto T., Hiraki T., Hatanaka K., Inoue H., Seki N. (2017) The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes. J Hum Genet., vol. 62, no. 7, pp. 671-678. doi: 10.1038/jhg.2017.27.
14. Niyazova R.Y., Аtambayeva S.А., Pyrkova А.Y., Ivashchenko A.T. (2015) Assotsiatsii miRNA i mRNA genov, uchastvuyushchih v razvitii nemelkokletochnogo raka legkih [Associations of miRNA and mRNA genes involved in the development of non-small cell lung cancer]. KazNU Bulletin. Biology series, vol. 65, no 3, pp. 143-148.
15. Pao W., Girard N. (2011) New driver mutations in non-small-cell lung cancer. Lancet Oncol., vol. 12, pp. 175–180. doi: 10.1016/S1470-2045(10)70087-5.
16. Shi Y.X., Yin J.Y., Shen Y., Zhang W., Zhou H.H., Liu Z.Q. (2017) Genome-scale analysis identifies NEK2, DLGAP5 and ECT2 as promising diagnostic and prognostic biomarkers in human lung cancer. Sci Rep., vol. 7, no. 1, pp. 8072. doi: 10.1038/s41598-017-08615-5.
17. Tabbò F., Nottegar A., Guerrera F., Migliore E., Luchini C., Maletta F., Veronese N., Montagna L., Gaudiano M., Di Giacomo F., Filosso P.L., Delsedime L., Ciccone G., Scarpa A., Sapino A., Oliaro A., Ruffini E., Inghirami G., Chilosi M. (2018) Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma. Hum Pathol., vol. 75, pp. 167-178. doi: 10.1016/j.humpath.2018.01.017.
18. Taguchi Y.H., Iwadate M., Umeyama H. (2016) SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer. BMC Med Genomics, Suppl 1, pp. 28. doi: 10.1186/s12920-016-0196-3.
19. Wang J., Song J., Gao Z., Huo X., Zhang Y., Wang W., Qi J., Zheng S. (2017) Analysis of gene expression profiles of non-small cell lung cancer at different stages reveals significantly altered biological functions and candidate genes. Oncol Rep., vol. 37, no. 3, pp. 1736-1746. doi: 10.3892/or.2017.5380.
20. Wang K., Li H., Chen R., Zhang Y., Sun X.X., Huang W., Bian H., Chen Z.N. (2017) Combination of CALR and PDIA3 is a potential prognostic biomarker for non-small cell lung cancer. Oncotarget, vol. 8, no. 57, pp. 96945-96957. doi: 10.18632/oncotarget.18547.
21. Zhang F., Zhang X., Meng J., Zhao Y., Liu X., Liu Y., Wang Y., Li Y., Sun Y., Wang Z., Mei Q., Zhang T. (2015) ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer. Oncotarget, vol. 6, no. 18, pp. 16239-52.
22. Zhang W., Cui Q., Qu W., Ding X., Jiang D., Liu H. (2018) TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma. Oncol Rep., doi: 10.3892/or.2018.6426. [Epub ahead of print]
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Niyazova, R. E., Mamirova, A., Atambayeva, S. A., & Ivashchenko, A. T. (2018). Characteristics of miRNA interaction with mRNA of candidate genes of the non-small cell lung cancer. ҚазҰУ Хабаршысы. Биология сериясы, 76(3), 83–96. https://doi.org/10.26577/eb-2018-3-1341
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МОЛЕКУЛЯРНАЯ БИОЛОГИЯ И ГЕНЕТИКА
