The miRNA-marker binding sites of breast cancer
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Keywords:
mRNA, miRNA, breast cancer, marker, miR-665, miR-4417.Abstract
1300 abstracts of articles devoted to search for miRNA markers for diagnostics of breast cancer were processed by miRCancer script. Search for binding sites of 357 miRNAs in mRNAs of 427 genes which proteins participate in breast cancer. The miRNA binding sites in 5’UTR, CDS, 3’UTR of mRNAs with free hybridization energy equaled greater than 90% were selected using MirTarget program. It was revealed, that miR-4417 and miR-665 are more prospect markers for prediction of breast cancerReferences
1 Jochelson M., Hayes D.F., Ganz P.A. Surveillance and monitoring in breast cancer survivors: maximizing benefit and minimizing harm // Am. Soc. Clin. Oncol. Educ. Book. 2013. – Vol.12. – P. 13–18.
2 Eberts E.M. The early diagnosis of cancer of the breast // Can. Med. Assoc J. 1934. – Vol. 31. – No. 1. – P. 9–14.
3 Simon K. Studies of diagnosis and prognosis of breast carcinoma from serum findings // Med. Monatsschr.1957. – Vol. 11. – No.12. – P. 794–800.
4 Iorio M.V., Ferracin M., Liu C.G., Veronese A., Spizzo R., Sabbioni S. et al. MicroRNA gene expression deregulation in human breast cancer // Cancer Res. 2005. – Vol. 65. – No. 16. – P. 7065–7070.
5 Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs // Science. 2001. – Vol. 294. – No. 5543. – P. 853–858.
6 Ramalingam P., Palanichamy J.K., Singh A., Das P., Bhagat M., Kassab M.A. et al. Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing // RNA. 2014. – Vol. 20. – No. 1. – P. 76–87.
7 Si H., Sun X., Chen Y., Cao Y., Chen S., Wang H., Hu C. Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer // J. C. Res. Clin. Oncol. 2013. – Vol. 139. – No. 2. – P. 223–229.
8 Murria E.R., Palanca S.S., de Juan J.I., Egoavil R.C., García-Casado Z., Juan F.M. et al. MicroRNA signatures in hereditary breast cancer // J. Breast C. Res. Treat. 2013. – Vol. 142. – No. 1. – P. 19–30.
9 Borgan E., Navon R., Vollan H.K., Schlichting E., Sauer T., Yakhini Z. et al. Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue // Mol. Oncol. 2011. – Vol. 5. – No. 6. – P. 564–576.
10 Addou-Klouche L., Adélaïde J., Cornen S., Bekhouche I., Finetti P., Guille A. et al. Integrated genomic analysis of breast cancers // Balk. J. Med. Genet. 2012. – Vol. 15. – P. 71–74.
11 Li Q., Li X., Guo Z., Xu F., Xia J., Liu Z. et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer // PLoS One. 2012. – Vol. 7. – No. 11. – P. 48278.
12 Yang M., Liu R., Sheng J., Liao J., Wang Y., Pan E. et al. Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma // Oncol. Rep. 2013. – Vol. 29. – No. 1. – P. 169–176.
13 Ji S., Ye G., Zhang J., Wang L., Wang T., Wang Z. et al. miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer // Gut. 2013. – Vol. 62. – No. 5. – P. 716–726.
14 Fan M., Li X., Jiang W., Huang Y., Li J., Wang Z. A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells // Exp. Ther. Med. 2013. – Vol. 5. – No. 4. – P. 1143–1146.
15 Guo L.H., Li H., Wang F., Yu J., He J.S. The Tumor suppressor roles of miR-433 and miR-127 in gastric cancer // Int. J. Mol. Sci. 2013. – Vol. 14. – P. 14171–14184.
2 Eberts E.M. The early diagnosis of cancer of the breast // Can. Med. Assoc J. 1934. – Vol. 31. – No. 1. – P. 9–14.
3 Simon K. Studies of diagnosis and prognosis of breast carcinoma from serum findings // Med. Monatsschr.1957. – Vol. 11. – No.12. – P. 794–800.
4 Iorio M.V., Ferracin M., Liu C.G., Veronese A., Spizzo R., Sabbioni S. et al. MicroRNA gene expression deregulation in human breast cancer // Cancer Res. 2005. – Vol. 65. – No. 16. – P. 7065–7070.
5 Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs // Science. 2001. – Vol. 294. – No. 5543. – P. 853–858.
6 Ramalingam P., Palanichamy J.K., Singh A., Das P., Bhagat M., Kassab M.A. et al. Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing // RNA. 2014. – Vol. 20. – No. 1. – P. 76–87.
7 Si H., Sun X., Chen Y., Cao Y., Chen S., Wang H., Hu C. Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer // J. C. Res. Clin. Oncol. 2013. – Vol. 139. – No. 2. – P. 223–229.
8 Murria E.R., Palanca S.S., de Juan J.I., Egoavil R.C., García-Casado Z., Juan F.M. et al. MicroRNA signatures in hereditary breast cancer // J. Breast C. Res. Treat. 2013. – Vol. 142. – No. 1. – P. 19–30.
9 Borgan E., Navon R., Vollan H.K., Schlichting E., Sauer T., Yakhini Z. et al. Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue // Mol. Oncol. 2011. – Vol. 5. – No. 6. – P. 564–576.
10 Addou-Klouche L., Adélaïde J., Cornen S., Bekhouche I., Finetti P., Guille A. et al. Integrated genomic analysis of breast cancers // Balk. J. Med. Genet. 2012. – Vol. 15. – P. 71–74.
11 Li Q., Li X., Guo Z., Xu F., Xia J., Liu Z. et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer // PLoS One. 2012. – Vol. 7. – No. 11. – P. 48278.
12 Yang M., Liu R., Sheng J., Liao J., Wang Y., Pan E. et al. Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma // Oncol. Rep. 2013. – Vol. 29. – No. 1. – P. 169–176.
13 Ji S., Ye G., Zhang J., Wang L., Wang T., Wang Z. et al. miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer // Gut. 2013. – Vol. 62. – No. 5. – P. 716–726.
14 Fan M., Li X., Jiang W., Huang Y., Li J., Wang Z. A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells // Exp. Ther. Med. 2013. – Vol. 5. – No. 4. – P. 1143–1146.
15 Guo L.H., Li H., Wang F., Yu J., He J.S. The Tumor suppressor roles of miR-433 and miR-127 in gastric cancer // Int. J. Mol. Sci. 2013. – Vol. 14. – P. 14171–14184.
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Berillo, O. A., & Régnier, M. (2015). The miRNA-marker binding sites of breast cancer. Experimental Biology, 60(1), 23–26. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/48
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Bioinformatics, Genomics and Proteomics. Physical-chemical Biology
