Characteristics of miRNA interaction with mRNAs of candidate genes of human cardiovascular diseases
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Keywords:
miRNA; mRNA; gene candidates; myocardial infarction; ischemic heart disease; arterial hypertension; atherosclerosis; metabolic syndromeAbstract
The binding of 6271 human miRNAs with mRNAs of 74 candidate genes was studied. These genes, presumably, can be biomarkers and play a key role in the development of myocardial infarction, ischemic heart disease, arterial hypertension, atherosclerosis and metabolic syndrome and perform various functions. Among the results obtained we have selected 438 miRNA binding sites in mRNAs of these genes, taking into account binding energy, ΔG/ΔGm ratio and the length of miRNAs. The largest number of binding sites (155) is found in mRNAs of ischemic heart disease gene candidates. Only four genes had miRNA binding sites in their mRNAs with ΔG/ΔGm value equal to 100%: TPM1, GATA5, NKX2-5 and F2. GATA4, NKX2-5, TTN, LDLR and PPARGC1A genes contained the largest number of miRNA binding sites in their mRNAs among studied genes. Based on the results obtained, we can make conclusion that the expression of gene candidates of ischemic heart disease is more strongly regulated by miRNAs than the expression of gene candidates of other cardiovascular diseases described in the article. Associations of miRNAs and mRNAs of candidate genes of myocardial infarction, ischemic heart disease, arterial hypertension, atherosclerosis and metabolic syndrome development were found. The following associations of miRNAs and mRNAs of candidate genes, characterizing by free energy of interaction equal and more than -130kJ/mole, can be recommended for diagnostics of myocardial infarction, ischemic heart disease, arterial hypertension, atherosclerosis and metabolic syndrome: ACE1 and miR-3-8100-5p; ACTA2 and miR-19-44540-3p; AST1 and miR-17-40081-5p; GATA2 and miR-7-21068-3p; GATA4 and miR-1-155-3p, miR-3-8100-5p, miR-2-3313-3p, miR-16-13062-5p; GATA6 and miR-6-17815-3p; HIF1A and miR-6789-5p, miR-6-16980-5p; INSR and miR-4-11316-5p; MAPK1 and miR-17-39570-5p, miR-12-33610-3p, miR-9-20317-3p, miR-19-41910-5p; MYL4 and miR-4763-3p; NKX2-5 and miR-19-21199-3p, miR-20-22562-3p, miR-2-3313-3p, miR-1-2121-3p; PPARGC1A and miR-9-20317-3p, miR-5-15733-3p; TNNI3 and miR-2-7379-5p; TPM1 and miR-15-35627-5p; VEGFB and miR-20-22562-3p, miR-19-33623-3p, miR-19-30988-5p, miR-19-21199-3p, miR-1-2121-3p; VEGFC and miR-15-32047-5p, miR-17-40081-5p, miR-2-3313-3p, miR-20-45152-5p; VLDLR and miR-9-20317-3p. It is possible to control in the blood concentrations of these associations of miRNAs and mRNAs of candidate genes, suggested for early diagnostics of cardiovascular diseases.
References
1 The World Health Organization. Cardiovascular diseases // Informational Bulletin of WHO. - 2015. - Vol. 93. - P. 285-360.
2 The World Health Organization. 10 leading causes of death in the world // Informational Bulletin of WHO. - 2014. - Vol. 92. - P. 1-74.
3 O'Gara P.T., Kushner F.G., Ascheim D.D. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines // Circulation. - 2012. - Vol. 12. - P. 362-425. DOI:10.1161/CIR.0b013e3182742cf6
4 Su Q., Li L., Zhao J., Sun Y., Yang H. MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization // Cell Physiology and Biochemistry. - 2017. - Vol. 43, No. 3. - P. 1012-1024. DOI: 10.1159/000481699
5 Zeman M., Okuliarova M. Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia // Clinical Science. - 2017. - Vol. 131, No. 23. - P. 2791-2794. DOI: 10.1042/CS20171255
6 Zaiou M., Amri E.H., Bakillah A. The clinical potential of adipogenesis and obesity-related microRNAs // Nutrition, Metabolism & Cardiovascular Diseases. - 2017. - Vol. 4753, No. 17. - P. 324-349. DOI: 10.1016/j.numecd.2017.10.015
7 Garcia-Romero N., Esteban-Rubio S., Rackov G., Carrión-Navarro J., Belda-Iniesta C., Ayuso-Sacido A. Extracellular vesicles compartment in liquid biopsies: Clinical application // Molecular Aspects of Medicine. - 2017. - Vol. 2997, No. 17. - P. 301-306. DOI: 10.1016/j.mam.2017.11.009
8 Londina E. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs // Proceedings of National Academy of Science of the United States of America. – 2015. – Vol. 112, No. 10. – P. 1106-1115. DOI: 10.1073/pnas.1420955112
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. –Vol. 10, No. 7. – P. 423-427. DOI: 10.6026/97320630010423
10 Ivashchenko A.T., Niiazova R.E., Atambaeva S.A., Pyrkova A.Y., Labeit Z., Aisina D.E., Iurikova O. Y., Pinskii I.V., Akimniiazova A.N., Baizhigitova D., Mamirova A.A. Detection of the associations of miRNAs with target genes participanting in the development of cardiovascular diseases // News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Biological and Medical. - 2017. - Vol. 5. - P. 39-48.
11 Bogomolovas J., Gasch A., Bajoras V., Karčiauskaitė D., Šerpytis P., Grabauskienė V., Labeit D., Labeit S. Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury // International Journal of Cardiology. - 2016. - Vol. 212. - P. 232-234. DOI: 10.1016/j.ijcard.2016.03.045
12 Kwasny C., Manuwald U., Kugler J., Rothe U. Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries // Hormone and Metabolic Research. - 2017. - Vol. 28. - P. 10-32. DOI: 10.1055/s-0043-122395
13 Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., Witt C.C., Becker K., Labeit S., Granzier H.L. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy // Circulation. - 2004. - Vol. 110, No. 2. - P. 155-162. https://doi.org/10.1161/01.CIR.0000135591.37759.AF
14 Bäck M., Pizarro R., Clavel M.A. Biomarkers in Mitral Regurgitation. Progress in Cardiovascular Diseases. - 2017. - Vol. 620, No. 17. - P. 49-56. DOI: 10.1016/j.pcad.2017.11.004
15 Chen G.H., Xu C.S., Zhang J., Li Q., Cui H.H., Li X., Chang L., Tang R., Xu J., Tian X., Huang P., Xu J., Jin C., Yang Y. Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1 // Frontiers in Pharmacology. - 2017. - Vol. 8, No. 775. - P. 61-70. DOI: 10.3389/fphar.2017.00775
16 Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas'ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors) // Asia-Pacific Journal of Clinical Oncology. - 2017. - Vol. 8. - P. 35-46. DOI: 10.1111/ajco.12780
17 Pfeffer T.J., Hilfiker-Kleiner D. Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems of Cardiology. - 2017. - P. 2806, No. 17. - P. 30160-30163. DOI: 10.1016/j.cpcardiol.2017.10.005
18 Malchow S., Loosse C., Sickmann A., Lorenz C. Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry // Proteomes. - 2017. - Vol. 5, No. 4. - P. 91-95. DOI: 10.3390/proteomes5040031
References
1 The World Health Organization. (2015) Cardiovascular diseases. Informational Bulletin of WHO, vol. 93, pp. 285-360.
2 The World Health Organization. (2014) 10 leading causes of death in the world. Informational Bulletin of WHO, vol. 92, pp. 1-74.
3 O'Gara P.T., Kushner F.G., Ascheim D.D. (2012) 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, vol. 12, pp. 362-425. DOI:10.1161/CIR.0b013e3182742cf6
4 Su Q., Li L., Zhao J., Sun Y., Yang H. (2017) MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization. Cell Physiology and Biochemistry, vol. 43, no. 3, pp. 1012-1024. DOI: 10.1159/000481699
5 Zeman M., Okuliarova M. (2017) Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia. Clinical Science, vol. 131, no. 23, pp. 2791-2794. DOI: 10.1042/CS20171255
6 Zaiou M., Amri E.H., Bakillah A. (2017) The clinical potential of adipogenesis and obesity-related microRNAs. Nutrition, Metabolism & Cardiovascular Diseases, vol. 4753, no. 17, pp. 324-349. DOI: 10.1016/j.numecd.2017.10.015
7 Garcia-Romero N., Esteban-Rubio S., Rackov G., Carrión-Navarro J., Belda-Iniesta C., Ayuso-Sacido A. (2017) Extracellular vesicles compartment in liquid biopsies: Clinical application. Molecular Aspects of Medicine, vol. 2997, no. 17, pp. 301-306. DOI: 10.1016/j.mam.2017.11.009
8 Londina E. (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proceedings of National Academy of Science of the United States of America, vol. 112, no. 10, p. 1106-1115. doi: 10.1073/pnas.1420955112
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. (2014) MiR-3960 binding sites with mRNA of human genes. Bioinformation, vol. 10, no. 7, pp. 423-427. DOI: 10.6026/97320630010423
10 Ivashchenko A.T., Niiazova R.E., Atambaeva S.A., Pyrkova A.Y., Labeit Z., Aisina D.E., Iurikova O.Y., Pinskii I.V., Akimniiazova A.N., Baizhigitova D., Mamirova A.A. (2017) Detection of the associations of miRNAs with target genes participanting in the development of cardiovascular diseases. News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Biological and Medical, vol. 5, pp. 39-48.
11 Bogomolovas J., Gasch A., Bajoras V., Karčiauskaitė D., Šerpytis P., Grabauskienė V., Labeit D., Labeit S. (2016) Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury. International Journal of Cardiology, vol. 212, pp. 232-234. DOI: 10.1016/j.ijcard.2016.03.045
12 Kwasny C., Manuwald U., Kugler J., Rothe U. (2017) Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries. Hormone and Metabolic Research, vol. 28, pp. 10-32. DOI: 10.1055/s-0043-122395
13 Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., Witt C.C., Becker K., Labeit S., Granzier H.L. (2004) Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation, vol. 110, no. 2, pp. 155-162. https://doi.org/10.1161/01.CIR.0000135591.37759.AF
14 Bäck M., Pizarro R., Clavel M.A. (2017) Biomarkers in Mitral Regurgitation. Progress in Cardiovascular Diseases, vol. 620, no. 17, pp. 49-56. DOI: 10.1016/j.pcad.2017.11.004
15 Chen G.H., Xu C.S., Zhang J., Li Q., Cui H.H., Li X., Chang L., Tang R., Xu J., Tian X., Huang P., Xu J., Jin C., Yang Y. (2017) Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1. Frontiers in Pharmacology, vol. 8, no. 775, pp. 61-70. DOI: 10.3389/fphar.2017.00775
16 Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas'ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. (2017) Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). Asia-Pacific Journal of Clinical Oncology, vol. 8, pp. 35-46. DOI: 10.1111/ajco.12780
17 Pfeffer T.J., Hilfiker-Kleiner D. (2017) Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems of Cardiology, vol. 2806, no. 17, pp. 30160-30163. DOI: 10.1016/j.cpcardiol.2017.10.005
18 Malchow S., Loosse C., Sickmann A., Lorenz C. (2017) Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry. Proteomes, vol. 5, no. 4, pp. 91-95. DOI: 10.3390/proteomes5040031
2 The World Health Organization. 10 leading causes of death in the world // Informational Bulletin of WHO. - 2014. - Vol. 92. - P. 1-74.
3 O'Gara P.T., Kushner F.G., Ascheim D.D. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines // Circulation. - 2012. - Vol. 12. - P. 362-425. DOI:10.1161/CIR.0b013e3182742cf6
4 Su Q., Li L., Zhao J., Sun Y., Yang H. MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization // Cell Physiology and Biochemistry. - 2017. - Vol. 43, No. 3. - P. 1012-1024. DOI: 10.1159/000481699
5 Zeman M., Okuliarova M. Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia // Clinical Science. - 2017. - Vol. 131, No. 23. - P. 2791-2794. DOI: 10.1042/CS20171255
6 Zaiou M., Amri E.H., Bakillah A. The clinical potential of adipogenesis and obesity-related microRNAs // Nutrition, Metabolism & Cardiovascular Diseases. - 2017. - Vol. 4753, No. 17. - P. 324-349. DOI: 10.1016/j.numecd.2017.10.015
7 Garcia-Romero N., Esteban-Rubio S., Rackov G., Carrión-Navarro J., Belda-Iniesta C., Ayuso-Sacido A. Extracellular vesicles compartment in liquid biopsies: Clinical application // Molecular Aspects of Medicine. - 2017. - Vol. 2997, No. 17. - P. 301-306. DOI: 10.1016/j.mam.2017.11.009
8 Londina E. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs // Proceedings of National Academy of Science of the United States of America. – 2015. – Vol. 112, No. 10. – P. 1106-1115. DOI: 10.1073/pnas.1420955112
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. –Vol. 10, No. 7. – P. 423-427. DOI: 10.6026/97320630010423
10 Ivashchenko A.T., Niiazova R.E., Atambaeva S.A., Pyrkova A.Y., Labeit Z., Aisina D.E., Iurikova O. Y., Pinskii I.V., Akimniiazova A.N., Baizhigitova D., Mamirova A.A. Detection of the associations of miRNAs with target genes participanting in the development of cardiovascular diseases // News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Biological and Medical. - 2017. - Vol. 5. - P. 39-48.
11 Bogomolovas J., Gasch A., Bajoras V., Karčiauskaitė D., Šerpytis P., Grabauskienė V., Labeit D., Labeit S. Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury // International Journal of Cardiology. - 2016. - Vol. 212. - P. 232-234. DOI: 10.1016/j.ijcard.2016.03.045
12 Kwasny C., Manuwald U., Kugler J., Rothe U. Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries // Hormone and Metabolic Research. - 2017. - Vol. 28. - P. 10-32. DOI: 10.1055/s-0043-122395
13 Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., Witt C.C., Becker K., Labeit S., Granzier H.L. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy // Circulation. - 2004. - Vol. 110, No. 2. - P. 155-162. https://doi.org/10.1161/01.CIR.0000135591.37759.AF
14 Bäck M., Pizarro R., Clavel M.A. Biomarkers in Mitral Regurgitation. Progress in Cardiovascular Diseases. - 2017. - Vol. 620, No. 17. - P. 49-56. DOI: 10.1016/j.pcad.2017.11.004
15 Chen G.H., Xu C.S., Zhang J., Li Q., Cui H.H., Li X., Chang L., Tang R., Xu J., Tian X., Huang P., Xu J., Jin C., Yang Y. Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1 // Frontiers in Pharmacology. - 2017. - Vol. 8, No. 775. - P. 61-70. DOI: 10.3389/fphar.2017.00775
16 Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas'ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors) // Asia-Pacific Journal of Clinical Oncology. - 2017. - Vol. 8. - P. 35-46. DOI: 10.1111/ajco.12780
17 Pfeffer T.J., Hilfiker-Kleiner D. Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems of Cardiology. - 2017. - P. 2806, No. 17. - P. 30160-30163. DOI: 10.1016/j.cpcardiol.2017.10.005
18 Malchow S., Loosse C., Sickmann A., Lorenz C. Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry // Proteomes. - 2017. - Vol. 5, No. 4. - P. 91-95. DOI: 10.3390/proteomes5040031
References
1 The World Health Organization. (2015) Cardiovascular diseases. Informational Bulletin of WHO, vol. 93, pp. 285-360.
2 The World Health Organization. (2014) 10 leading causes of death in the world. Informational Bulletin of WHO, vol. 92, pp. 1-74.
3 O'Gara P.T., Kushner F.G., Ascheim D.D. (2012) 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, vol. 12, pp. 362-425. DOI:10.1161/CIR.0b013e3182742cf6
4 Su Q., Li L., Zhao J., Sun Y., Yang H. (2017) MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization. Cell Physiology and Biochemistry, vol. 43, no. 3, pp. 1012-1024. DOI: 10.1159/000481699
5 Zeman M., Okuliarova M. (2017) Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia. Clinical Science, vol. 131, no. 23, pp. 2791-2794. DOI: 10.1042/CS20171255
6 Zaiou M., Amri E.H., Bakillah A. (2017) The clinical potential of adipogenesis and obesity-related microRNAs. Nutrition, Metabolism & Cardiovascular Diseases, vol. 4753, no. 17, pp. 324-349. DOI: 10.1016/j.numecd.2017.10.015
7 Garcia-Romero N., Esteban-Rubio S., Rackov G., Carrión-Navarro J., Belda-Iniesta C., Ayuso-Sacido A. (2017) Extracellular vesicles compartment in liquid biopsies: Clinical application. Molecular Aspects of Medicine, vol. 2997, no. 17, pp. 301-306. DOI: 10.1016/j.mam.2017.11.009
8 Londina E. (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proceedings of National Academy of Science of the United States of America, vol. 112, no. 10, p. 1106-1115. doi: 10.1073/pnas.1420955112
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. (2014) MiR-3960 binding sites with mRNA of human genes. Bioinformation, vol. 10, no. 7, pp. 423-427. DOI: 10.6026/97320630010423
10 Ivashchenko A.T., Niiazova R.E., Atambaeva S.A., Pyrkova A.Y., Labeit Z., Aisina D.E., Iurikova O.Y., Pinskii I.V., Akimniiazova A.N., Baizhigitova D., Mamirova A.A. (2017) Detection of the associations of miRNAs with target genes participanting in the development of cardiovascular diseases. News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Biological and Medical, vol. 5, pp. 39-48.
11 Bogomolovas J., Gasch A., Bajoras V., Karčiauskaitė D., Šerpytis P., Grabauskienė V., Labeit D., Labeit S. (2016) Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury. International Journal of Cardiology, vol. 212, pp. 232-234. DOI: 10.1016/j.ijcard.2016.03.045
12 Kwasny C., Manuwald U., Kugler J., Rothe U. (2017) Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries. Hormone and Metabolic Research, vol. 28, pp. 10-32. DOI: 10.1055/s-0043-122395
13 Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., Witt C.C., Becker K., Labeit S., Granzier H.L. (2004) Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation, vol. 110, no. 2, pp. 155-162. https://doi.org/10.1161/01.CIR.0000135591.37759.AF
14 Bäck M., Pizarro R., Clavel M.A. (2017) Biomarkers in Mitral Regurgitation. Progress in Cardiovascular Diseases, vol. 620, no. 17, pp. 49-56. DOI: 10.1016/j.pcad.2017.11.004
15 Chen G.H., Xu C.S., Zhang J., Li Q., Cui H.H., Li X., Chang L., Tang R., Xu J., Tian X., Huang P., Xu J., Jin C., Yang Y. (2017) Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1. Frontiers in Pharmacology, vol. 8, no. 775, pp. 61-70. DOI: 10.3389/fphar.2017.00775
16 Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas'ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. (2017) Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). Asia-Pacific Journal of Clinical Oncology, vol. 8, pp. 35-46. DOI: 10.1111/ajco.12780
17 Pfeffer T.J., Hilfiker-Kleiner D. (2017) Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems of Cardiology, vol. 2806, no. 17, pp. 30160-30163. DOI: 10.1016/j.cpcardiol.2017.10.005
18 Malchow S., Loosse C., Sickmann A., Lorenz C. (2017) Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry. Proteomes, vol. 5, no. 4, pp. 91-95. DOI: 10.3390/proteomes5040031
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Published
2018-01-01
How to Cite
Pinskiy, I., Labeit, S., Labeit, D., & Ivashchenko, A. (2018). Characteristics of miRNA interaction with mRNAs of candidate genes of human cardiovascular diseases. Experimental Biology, 72(3), 54–69. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/1279
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МOLECULAR BIOLOGY AND GENETICS
