Характеристики взаимодействия miRNA c mRNA кандидатных генов сердечно-сосудистых заболеваний человека
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Кілттік сөздер:
miRNA; mRNA; инфаркт миокарда; ишемическая болезнь сердца; артериальная гипертензия; атеросклероз; метаболический синдромАннотация
Было изучено связывание 6271 miRNA человека с mRNA 74 кандидатных генов, которые, предположительно, могут быть биомаркерами и играть ключевую роль в развитии инфаркта миокарда, ишемической болезни сердца, артериальной гипертензии, атеросклероза и метаболического синдрома. Среди полученных результатов мы отобрали 438 сайтов связывания miRNA в mRNA этих генов с учётом энергии связывания, величины ∆G/∆Gm и длины miRNA. Больше всего сайтов связывания выявлено у кандидатных генов ишемической болезни сердца (155). Только четыре гена в своих mRNA имели сайты связывания miRNA с величиной ∆G/∆Gm, равной 100%: ген сердечного тропомиозина TPM1, гены транскрипционных факторов GATA5 и NKX2-5, ген фактора свёртываемости крови F2 (протромбина). Наибольшее число сайтов связывания miRNA cреди рассмотренных генов содержалось в mRNA генов GATA4, NKX2-5, TTN, LDLR и PPARGC1A. На основе полученных результатов можно сделать вывод, что экспрессия генов, связанных с развитием ишемической болезни сердца, в большей степени регулируется с помощью miRNA, чем экспрессия других генов рассмотренных в статье сердечно-сосудистых заболеваний человека.
Библиографиялық сілтемелер
1 The World Health Organization. Cardiovascular diseases // Informational Bulletin of WHO. - 2015. - Vol. 93. - P. 285-360.
2 The World Health Organization. 10 leading causes of death in the world // Informational Bulletin of WHO. - 2014. - Vol. 92. - P. 1-74.
3 O'Gara P.T., Kushner F.G., Ascheim D.D. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines // Circulation. - 2012. - Vol. 12. - P. 362-425. DOI:10.1161/CIR.0b013e3182742cf6
4 Su Q., Li L., Zhao J., Sun Y., Yang H. MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization // Cell Physiology and Biochemistry. - 2017. - Vol. 43, No. 3. - P. 1012-1024. DOI: 10.1159/000481699
5 Zeman M., Okuliarova M. Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia // Clinical Science. - 2017. - Vol. 131, No. 23. - P. 2791-2794. DOI: 10.1042/CS20171255
6 Zaiou M., Amri E.H., Bakillah A. The clinical potential of adipogenesis and obesity-related microRNAs // Nutrition, Metabolism & Cardiovascular Diseases. - 2017. - Vol. 4753, No. 17. - P. 324-349. DOI: 10.1016/j.numecd.2017.10.015
7 Garcia-Romero N., Esteban-Rubio S., Rackov G., Carrión-Navarro J., Belda-Iniesta C., Ayuso-Sacido A. Extracellular vesicles compartment in liquid biopsies: Clinical application // Molecular Aspects of Medicine. - 2017. - Vol. 2997, No. 17. - P. 301-306. DOI: 10.1016/j.mam.2017.11.009
8 Londina E. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs // Proceedings of National Academy of Science of the United States of America. – 2015. – Vol. 112, No. 10. – P. 1106-1115. DOI: 10.1073/pnas.1420955112
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. –Vol. 10, No. 7. – P. 423-427. DOI: 10.6026/97320630010423
10 Ivashchenko A.T., Niiazova R.E., Atambaeva S.A., Pyrkova A.Y., Labeit Z., Aisina D.E., Iurikova O. Y., Pinskii I.V., Akimniiazova A.N., Baizhigitova D., Mamirova A.A. Detection of the associations of miRNAs with target genes participanting in the development of cardiovascular diseases // News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Biological and Medical. - 2017. - Vol. 5. - P. 39-48.
11 Bogomolovas J., Gasch A., Bajoras V., Karčiauskaitė D., Šerpytis P., Grabauskienė V., Labeit D., Labeit S. Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury // International Journal of Cardiology. - 2016. - Vol. 212. - P. 232-234. DOI: 10.1016/j.ijcard.2016.03.045
12 Kwasny C., Manuwald U., Kugler J., Rothe U. Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries // Hormone and Metabolic Research. - 2017. - Vol. 28. - P. 10-32. DOI: 10.1055/s-0043-122395
13 Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., Witt C.C., Becker K., Labeit S., Granzier H.L. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy // Circulation. - 2004. - Vol. 110, No. 2. - P. 155-162. https://doi.org/10.1161/01.CIR.0000135591.37759.AF
14 Bäck M., Pizarro R., Clavel M.A. Biomarkers in Mitral Regurgitation. Progress in Cardiovascular Diseases. - 2017. - Vol. 620, No. 17. - P. 49-56. DOI: 10.1016/j.pcad.2017.11.004
15 Chen G.H., Xu C.S., Zhang J., Li Q., Cui H.H., Li X., Chang L., Tang R., Xu J., Tian X., Huang P., Xu J., Jin C., Yang Y. Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1 // Frontiers in Pharmacology. - 2017. - Vol. 8, No. 775. - P. 61-70. DOI: 10.3389/fphar.2017.00775
16 Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas'ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors) // Asia-Pacific Journal of Clinical Oncology. - 2017. - Vol. 8. - P. 35-46. DOI: 10.1111/ajco.12780
17 Pfeffer T.J., Hilfiker-Kleiner D. Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems of Cardiology. - 2017. - P. 2806, No. 17. - P. 30160-30163. DOI: 10.1016/j.cpcardiol.2017.10.005
18 Malchow S., Loosse C., Sickmann A., Lorenz C. Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry // Proteomes. - 2017. - Vol. 5, No. 4. - P. 91-95. DOI: 10.3390/proteomes5040031
References
1 The World Health Organization. (2015) Cardiovascular diseases. Informational Bulletin of WHO, vol. 93, pp. 285-360.
2 The World Health Organization. (2014) 10 leading causes of death in the world. Informational Bulletin of WHO, vol. 92, pp. 1-74.
3 O'Gara P.T., Kushner F.G., Ascheim D.D. (2012) 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, vol. 12, pp. 362-425. DOI:10.1161/CIR.0b013e3182742cf6
4 Su Q., Li L., Zhao J., Sun Y., Yang H. (2017) MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization. Cell Physiology and Biochemistry, vol. 43, no. 3, pp. 1012-1024. DOI: 10.1159/000481699
5 Zeman M., Okuliarova M. (2017) Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia. Clinical Science, vol. 131, no. 23, pp. 2791-2794. DOI: 10.1042/CS20171255
6 Zaiou M., Amri E.H., Bakillah A. (2017) The clinical potential of adipogenesis and obesity-related microRNAs. Nutrition, Metabolism & Cardiovascular Diseases, vol. 4753, no. 17, pp. 324-349. DOI: 10.1016/j.numecd.2017.10.015
7 Garcia-Romero N., Esteban-Rubio S., Rackov G., Carrión-Navarro J., Belda-Iniesta C., Ayuso-Sacido A. (2017) Extracellular vesicles compartment in liquid biopsies: Clinical application. Molecular Aspects of Medicine, vol. 2997, no. 17, pp. 301-306. DOI: 10.1016/j.mam.2017.11.009
8 Londina E. (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proceedings of National Academy of Science of the United States of America, vol. 112, no. 10, p. 1106-1115. doi: 10.1073/pnas.1420955112
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. (2014) MiR-3960 binding sites with mRNA of human genes. Bioinformation, vol. 10, no. 7, pp. 423-427. DOI: 10.6026/97320630010423
10 Ivashchenko A.T., Niiazova R.E., Atambaeva S.A., Pyrkova A.Y., Labeit Z., Aisina D.E., Iurikova O.Y., Pinskii I.V., Akimniiazova A.N., Baizhigitova D., Mamirova A.A. (2017) Detection of the associations of miRNAs with target genes participanting in the development of cardiovascular diseases. News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Biological and Medical, vol. 5, pp. 39-48.
11 Bogomolovas J., Gasch A., Bajoras V., Karčiauskaitė D., Šerpytis P., Grabauskienė V., Labeit D., Labeit S. (2016) Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury. International Journal of Cardiology, vol. 212, pp. 232-234. DOI: 10.1016/j.ijcard.2016.03.045
12 Kwasny C., Manuwald U., Kugler J., Rothe U. (2017) Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries. Hormone and Metabolic Research, vol. 28, pp. 10-32. DOI: 10.1055/s-0043-122395
13 Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., Witt C.C., Becker K., Labeit S., Granzier H.L. (2004) Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation, vol. 110, no. 2, pp. 155-162. https://doi.org/10.1161/01.CIR.0000135591.37759.AF
14 Bäck M., Pizarro R., Clavel M.A. (2017) Biomarkers in Mitral Regurgitation. Progress in Cardiovascular Diseases, vol. 620, no. 17, pp. 49-56. DOI: 10.1016/j.pcad.2017.11.004
15 Chen G.H., Xu C.S., Zhang J., Li Q., Cui H.H., Li X., Chang L., Tang R., Xu J., Tian X., Huang P., Xu J., Jin C., Yang Y. (2017) Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1. Frontiers in Pharmacology, vol. 8, no. 775, pp. 61-70. DOI: 10.3389/fphar.2017.00775
16 Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas'ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. (2017) Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). Asia-Pacific Journal of Clinical Oncology, vol. 8, pp. 35-46. DOI: 10.1111/ajco.12780
17 Pfeffer T.J., Hilfiker-Kleiner D. (2017) Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems of Cardiology, vol. 2806, no. 17, pp. 30160-30163. DOI: 10.1016/j.cpcardiol.2017.10.005
18 Malchow S., Loosse C., Sickmann A., Lorenz C. (2017) Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry. Proteomes, vol. 5, no. 4, pp. 91-95. DOI: 10.3390/proteomes5040031
2 The World Health Organization. 10 leading causes of death in the world // Informational Bulletin of WHO. - 2014. - Vol. 92. - P. 1-74.
3 O'Gara P.T., Kushner F.G., Ascheim D.D. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines // Circulation. - 2012. - Vol. 12. - P. 362-425. DOI:10.1161/CIR.0b013e3182742cf6
4 Su Q., Li L., Zhao J., Sun Y., Yang H. MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization // Cell Physiology and Biochemistry. - 2017. - Vol. 43, No. 3. - P. 1012-1024. DOI: 10.1159/000481699
5 Zeman M., Okuliarova M. Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia // Clinical Science. - 2017. - Vol. 131, No. 23. - P. 2791-2794. DOI: 10.1042/CS20171255
6 Zaiou M., Amri E.H., Bakillah A. The clinical potential of adipogenesis and obesity-related microRNAs // Nutrition, Metabolism & Cardiovascular Diseases. - 2017. - Vol. 4753, No. 17. - P. 324-349. DOI: 10.1016/j.numecd.2017.10.015
7 Garcia-Romero N., Esteban-Rubio S., Rackov G., Carrión-Navarro J., Belda-Iniesta C., Ayuso-Sacido A. Extracellular vesicles compartment in liquid biopsies: Clinical application // Molecular Aspects of Medicine. - 2017. - Vol. 2997, No. 17. - P. 301-306. DOI: 10.1016/j.mam.2017.11.009
8 Londina E. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs // Proceedings of National Academy of Science of the United States of America. – 2015. – Vol. 112, No. 10. – P. 1106-1115. DOI: 10.1073/pnas.1420955112
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. MiR-3960 binding sites with mRNA of human genes // Bioinformation. – 2014. –Vol. 10, No. 7. – P. 423-427. DOI: 10.6026/97320630010423
10 Ivashchenko A.T., Niiazova R.E., Atambaeva S.A., Pyrkova A.Y., Labeit Z., Aisina D.E., Iurikova O. Y., Pinskii I.V., Akimniiazova A.N., Baizhigitova D., Mamirova A.A. Detection of the associations of miRNAs with target genes participanting in the development of cardiovascular diseases // News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Biological and Medical. - 2017. - Vol. 5. - P. 39-48.
11 Bogomolovas J., Gasch A., Bajoras V., Karčiauskaitė D., Šerpytis P., Grabauskienė V., Labeit D., Labeit S. Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury // International Journal of Cardiology. - 2016. - Vol. 212. - P. 232-234. DOI: 10.1016/j.ijcard.2016.03.045
12 Kwasny C., Manuwald U., Kugler J., Rothe U. Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries // Hormone and Metabolic Research. - 2017. - Vol. 28. - P. 10-32. DOI: 10.1055/s-0043-122395
13 Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., Witt C.C., Becker K., Labeit S., Granzier H.L. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy // Circulation. - 2004. - Vol. 110, No. 2. - P. 155-162. https://doi.org/10.1161/01.CIR.0000135591.37759.AF
14 Bäck M., Pizarro R., Clavel M.A. Biomarkers in Mitral Regurgitation. Progress in Cardiovascular Diseases. - 2017. - Vol. 620, No. 17. - P. 49-56. DOI: 10.1016/j.pcad.2017.11.004
15 Chen G.H., Xu C.S., Zhang J., Li Q., Cui H.H., Li X., Chang L., Tang R., Xu J., Tian X., Huang P., Xu J., Jin C., Yang Y. Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1 // Frontiers in Pharmacology. - 2017. - Vol. 8, No. 775. - P. 61-70. DOI: 10.3389/fphar.2017.00775
16 Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas'ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors) // Asia-Pacific Journal of Clinical Oncology. - 2017. - Vol. 8. - P. 35-46. DOI: 10.1111/ajco.12780
17 Pfeffer T.J., Hilfiker-Kleiner D. Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems of Cardiology. - 2017. - P. 2806, No. 17. - P. 30160-30163. DOI: 10.1016/j.cpcardiol.2017.10.005
18 Malchow S., Loosse C., Sickmann A., Lorenz C. Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry // Proteomes. - 2017. - Vol. 5, No. 4. - P. 91-95. DOI: 10.3390/proteomes5040031
References
1 The World Health Organization. (2015) Cardiovascular diseases. Informational Bulletin of WHO, vol. 93, pp. 285-360.
2 The World Health Organization. (2014) 10 leading causes of death in the world. Informational Bulletin of WHO, vol. 92, pp. 1-74.
3 O'Gara P.T., Kushner F.G., Ascheim D.D. (2012) 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, vol. 12, pp. 362-425. DOI:10.1161/CIR.0b013e3182742cf6
4 Su Q., Li L., Zhao J., Sun Y., Yang H. (2017) MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization. Cell Physiology and Biochemistry, vol. 43, no. 3, pp. 1012-1024. DOI: 10.1159/000481699
5 Zeman M., Okuliarova M. (2017) Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia. Clinical Science, vol. 131, no. 23, pp. 2791-2794. DOI: 10.1042/CS20171255
6 Zaiou M., Amri E.H., Bakillah A. (2017) The clinical potential of adipogenesis and obesity-related microRNAs. Nutrition, Metabolism & Cardiovascular Diseases, vol. 4753, no. 17, pp. 324-349. DOI: 10.1016/j.numecd.2017.10.015
7 Garcia-Romero N., Esteban-Rubio S., Rackov G., Carrión-Navarro J., Belda-Iniesta C., Ayuso-Sacido A. (2017) Extracellular vesicles compartment in liquid biopsies: Clinical application. Molecular Aspects of Medicine, vol. 2997, no. 17, pp. 301-306. DOI: 10.1016/j.mam.2017.11.009
8 Londina E. (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proceedings of National Academy of Science of the United States of America, vol. 112, no. 10, p. 1106-1115. doi: 10.1073/pnas.1420955112
9 Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. (2014) MiR-3960 binding sites with mRNA of human genes. Bioinformation, vol. 10, no. 7, pp. 423-427. DOI: 10.6026/97320630010423
10 Ivashchenko A.T., Niiazova R.E., Atambaeva S.A., Pyrkova A.Y., Labeit Z., Aisina D.E., Iurikova O.Y., Pinskii I.V., Akimniiazova A.N., Baizhigitova D., Mamirova A.A. (2017) Detection of the associations of miRNAs with target genes participanting in the development of cardiovascular diseases. News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Biological and Medical, vol. 5, pp. 39-48.
11 Bogomolovas J., Gasch A., Bajoras V., Karčiauskaitė D., Šerpytis P., Grabauskienė V., Labeit D., Labeit S. (2016) Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury. International Journal of Cardiology, vol. 212, pp. 232-234. DOI: 10.1016/j.ijcard.2016.03.045
12 Kwasny C., Manuwald U., Kugler J., Rothe U. (2017) Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries. Hormone and Metabolic Research, vol. 28, pp. 10-32. DOI: 10.1055/s-0043-122395
13 Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., Witt C.C., Becker K., Labeit S., Granzier H.L. (2004) Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation, vol. 110, no. 2, pp. 155-162. https://doi.org/10.1161/01.CIR.0000135591.37759.AF
14 Bäck M., Pizarro R., Clavel M.A. (2017) Biomarkers in Mitral Regurgitation. Progress in Cardiovascular Diseases, vol. 620, no. 17, pp. 49-56. DOI: 10.1016/j.pcad.2017.11.004
15 Chen G.H., Xu C.S., Zhang J., Li Q., Cui H.H., Li X., Chang L., Tang R., Xu J., Tian X., Huang P., Xu J., Jin C., Yang Y. (2017) Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1. Frontiers in Pharmacology, vol. 8, no. 775, pp. 61-70. DOI: 10.3389/fphar.2017.00775
16 Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas'ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. (2017) Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). Asia-Pacific Journal of Clinical Oncology, vol. 8, pp. 35-46. DOI: 10.1111/ajco.12780
17 Pfeffer T.J., Hilfiker-Kleiner D. (2017) Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. Current Problems of Cardiology, vol. 2806, no. 17, pp. 30160-30163. DOI: 10.1016/j.cpcardiol.2017.10.005
18 Malchow S., Loosse C., Sickmann A., Lorenz C. (2017) Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry. Proteomes, vol. 5, no. 4, pp. 91-95. DOI: 10.3390/proteomes5040031
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Как цитировать
Pinskiy, I., Labeit, S., Labeit, D., & Ivashchenko, A. (2018). Характеристики взаимодействия miRNA c mRNA кандидатных генов сердечно-сосудистых заболеваний человека. ҚазҰУ Хабаршысы. Биология сериясы, 72(3), 54–69. вилучено із https://bb.kaznu.kz/index.php/biology/article/view/1279
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