GENES ASSOCIATED WITH THE DEVELOPMENT OF MYOCARDIAL INFARCTION
Keywords:
myocardial infarction, gene, microRNA, mRNA, diagnostics.Abstract
The search of the genes-candidates associated with the development of myocardial infarction is conducted. A database of genes associated with the development of myocardial infarction is created and the functions of these genes analyzed in a comparative aspect. It has been shown that many of the genes involved in the development of myocardial infarction associated with the development of other cardiovascular diseases: ischemic heart disease, hypertension, atherosclerosis, metabolic syndrome. Participating of these genes in different social meaningful diseases is analysed. A database of genes associated with the development of myocardial infarction is the basis for the identification of genes which expression is dependent on the action of microRNAs. The features of resulting database of genes and their using in the development of myocardial infarction early diagnostics methods with the help of molecular genetic markers are discussed.References
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2. El-Aziz A.T.A., Rezk N.A. Relation of PAI-1 and TPA genes polymorphisms to acute myocardial infarction and its outcomes in Egyptian patients// Cell Biochemistry & Biophysics. - 2015. – V. 71, N. 1. – P. 227-234.
3. Shevchenko A.V., Konenkov V.I., Prokof'ev V.F., Pokushalov E.A. Analysis of genotype combinations at the polymorphic points of the promoter regions of the genes of three matrix metalloproteinases and the gene of vascular endothelial growth factor (VEGF) in patients with history of acute myocardial infarction// Terapevticheskii Arkhiv. – 2014. – V. 86, N. 4. – P. 19-24.
4. Xu X., Wang L.H., Liu H.B., et al. Association of chemokines and their receptors genes polymorphisms with risk of myocardial infarction // Zhonghua Yi Xue Yi Chuan Xue Za Zhi. – 2013. - V. 30, N. 5. – P. 601-607.
5. Helseth R., Seljeflot I., Opstad T., et al. Genes expressed in coronary thrombi are associated with ischemic time in patients with acute myocardial infarction // Thromb Research. – 2015. – V. 135, N. 2. – P. 329-333.
6. Kovacs V., Gasz B., Balatonyi B., et al. Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: a preliminary study // Molecular & Cell Biochemistry. – 2014. – V. 389, N. 1-2. – P. 79-84.
7. Sakowicz A., Fendler W., Lelonek M., Sakowicz B., Pietrucha T. Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age // Biochemical Genetics. – 2013. – V. 51, N. 3-4. – P. 230-242.
8. Wang Y., Wang L., Liu X., Zhang Y., et al. Genetic variants associated with myocardial infarction and the risk factors in Chinese population // Public Library of Science One. – 2014. – V. 9, N. 1. – P. 863.
9. Zhang T., Zhao L.L., Zhang Z.R., Fu P.D., Su Z.D., Qi L.C., Li X.Q., Dong Y.M. Interaction network analysis revealed biomarkers in myocardial infarction // Molecular Biology Report. – 2014. – V. 41, N. 8. – P. 4997-5003.
10. Liu Q., Du G.Q., Zhu Z.T. Identification of apoptosis-related microRNAs and their target genes in myocardial infarction post-transplantation with skeletal myoblasts // Journal of Translational Medicine. – 2015. – V. 19. – P. 13-27.
11. Wang N., Zhou Z., Liao X., Zhang T. Role of microRNAs in cardiac hypertrophy and heart failure // IUBMB Life. - 2009. - V. 61, N. 6. - P. 566-571.
12. Ye Y., Perez-Polo J.R., Qian J., Birnbaum Y. The role of microRNA in modulating myocardial ischemia-reperfusion injury // Physiological Genomics. - 2011. - V. 43, N. 10. - P. 534-542.
13. Ono K., Kuwabara Y., Han J. MicroRNAs and cardiovascular diseases // Federation of European Biochemical Societies Journal. - 2011. - V. 278, N. 10. - P. 1619-1633.
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