TOR сигнальная система в растениях
DOI:
https://doi.org/10.26577/eb-2019-2-1413Аннотация
Мишень рапамицина млекопитающих (Mammalian target of rapamycin (mTOR)) представляет собой серин-треониновую киназу, которая функционирует в качестве центрального элемента в сигнальном пути, отвечающем за клеточную реакцию на стрессы и доступность питательных веществ/энергии, и обеспечивает соответствующие изменения процессов роста, пролиферации и выживания клеток, а также синтеза белка. До настоящего времени изучение молекулярных механизмов TOR сигнальной системы в основном было сосредоточено на клетках дрожжей и животных. Растительные организмы, в большинстве своем неподвижные и ограниченные к одному месту обитания, обязаны постоянно подстраивать темпы роста (выраженного в увеличении размеров органов) и развития (состоящего в формировании новых органов и структур) в зависимости от наличия питательных веществ. Кроме того, растения также преодолевают неблагоприятные внешние факторы, не имея возможности их физически избежать. TOR сигнальная система является центром регуляторных сетей поддержания баланса между защитой и ростом у всех эукариот. Следовательно, раскрытие молекулярных механизмов TOR сигнальной системы у растений является ключом к контролю устойчивости к стрессу и продуктивности растений. Последние достижения в изучении пути передачи сигналов TOR у растений позволяют предположить значительное совпадение клеточных процессов и процессов развития, которые регулируются TOR у растений, животных и людей. Целью данного обзора является раскрытие последних достижений в исследованиях пути передачи сигналов TOR у растений.
Ключевые слова: TOR, млекопитающие, растения, водоросли, Saccharomyces cerevisiae, рапамицин, аутофагия, раптор.
Библиографиялық сілтемелер
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13. Deng K., Dong P., Wang W., Feng L., Xiong F., Wang K., Zhang S., Feng S., Wang B., Zhang J. et al. (2017). The TOR pathway is involved in adventitious root formation in Arabidopsis and potato. Front. Plant Sci. 8, 784.
14. Song Y., Zhao G., Zhang X.Y., Li L.X., Xiong F.J., Zhuo F.P., et al. (2017). The crosstalk between target of rapamycin (TOR) and Jasmonic Acid (JA) signaling existing in Arabidopsis and cotton. Sci. Rep. 7:45830.
15. Heitman J., Movva N.R. and Hall M.N. (1991). Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253, 905-909.
16. Stan R., Mclaughlin M. M., Cafferkey R., Johnson R.K., Rosenberg M., Livi G.P. (1994). Interaction between Fkbp12-Rapamycin and Tor Involves a Conserved Serine Residue. Journal of Biological Chemistry 269, 32027- 32030.
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19. Thoreen C.C. (2017). The molecular basis of mTORC1-regulated translation. Biochemical Society Transactions 45, 213-221.
20. Zhao J., Zhai B., Gygi S. P., Goldberg A. L. (2015). mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. Proceedings of the National Academy of Sciences, USA 112, 15790-15797.
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Alybayev, D. S., & Bissenbaev, A. K. (2019). TOR сигнальная система в растениях. ҚазҰУ Хабаршысы. Биология сериясы, 79(2), 4–17. https://doi.org/10.26577/eb-2019-2-1413
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