The influence of amino acids on biosynthesis of the antibiotic A-70, active against methicillin-resistant Staphylococci with multiple drug-resistance.
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Keywords:
methyl-persistent staphylococcus, antibiotic, biosynthesis, amino-acid,Abstract
The influence of certain amino acids on the formation of the antibacterial antibiotic-peptolide A-70 was investigated. There was determined the positive influence of valine, glutаmine and phenylalanine on accumulation of the antibiotic A-70 in culture broth: biosynthesis of the antibiotic increased by 11.1-13.3%. Asparagine, arginine, alanine, cysteine, proline, leucine, and lysine inhibit biosynthesis of the antibiotic A-70.References
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among patients with Staphylococcus aureus surgical site infection // Clin. Infect. Dis. – 2003. - № 36. - Р. 592-597.
2 Rubin R.J., Harrington C.A., Poon A. The economic impact of Staphylococcus aureus infections in New York City
hospitals // Emerg. Infect. Dis. - 1999. – Vol. 5. - Р. 9-17.
3 Lowy F.D. Antimicrobial resistance: the example of Staphylococcus aureus // J. Clin. Invest. - 2003. – Vol. 111. -№ 9. – P. 1265-1273.
4 Rybak M.J., Pharm D.K.L. Community-associated methicillin-resistant Staphylococcus aureus: a review // Pharmacotherapy.- 2005. – Vol. 25. - № 1. – Р. 74-85.
5 KatzЕ., BrownD. A possible role of D-valine and related D-amino acids n repression of enzyme and actinomycin
synthesis//Appl. Microbiol. Biotechnol. -1989. –Vol. 30. – P. 67-70.
6 Martin J.F., Demain A.L.Control of antibiotic biosynthesis.Microbiol. Rev. – 1980. – Vol. 44. – P. 230-251.
7 Егоров Н.С. Основы учения об антибиотиках. - М.: МГУ, Наука, 2004. - 528 с.
8 МУК 4.2.1890-04 Определение чувствительности микроорганизмов к антибактериальным препаратам //
Клиническая микробиология и антимикробная химиотерапия. – 2004. – Т. 6. - № 4. – С. 306-359.
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Trenozhnikova, L. P., Khassenova, A. K., Akilova, M. A., Ultanbekova, G. D., & Baydyldaeva, Z. A. (2015). The influence of amino acids on biosynthesis of the antibiotic A-70, active against methicillin-resistant Staphylococci with multiple drug-resistance. Experimental Biology, 60(2), 356–359. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/973
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BIOTECHNOLOGY
