C-Kit proto-oncogene participation in tumor development
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Keywords:
proto-oncogene c-Kit, c-Kit ligand (Stem cell factor – SCF), proliferation, oncology, therapy,Abstract
The literature on the proto-oncogene C-Kit binding with the induction of tumor is given. In experimental papers is shown that C-Kit plays a main role in the tumor occurrence. Mutations in this gene cause specific expression of certain genes, disrupt the regulation of cellular differentiation, proliferation and inhibit cellular apoptosis. The leading role of c-Kit in the development of tumors was explained, it can be used as a target in cancer therapy.References
1 Galli S.J., Zsebo K.M., Geissler E.N. The kit ligand, stem cell factor // Adv Immunol. – 1994. – Vol. 55. – P. 1-96.
2 Chen SQ, Xiong AQ. The progress and implication of stem cell factor // Basic Medical Sciences and Clinics. – 2002. – Vol.22(5). – P. 385-390.
3 Antonescu CR. The GIST paradigm: lessons for other kinase-driven cancers // J Pathol. – 2011. – Vol. 223(2). – P. 251-261
4 Besmer P, Murphy JE, George PC, et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family // Nature. – 1986. – Vol. 320 (6061). – P.415-421
5 Lemmon MA, Ferguson KM. A new twist in the transmembrane signaling tool-kit // Cell. – 2007. – Vol. 130 (2). – P. 213-215
6 Jing Liang, Yan-Ling Wu, Bing-Jia Chen, Wen Zhang, Yoshimasa Tanaka and Hiroshi Sugiyama. The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases // International Journal of Biological Sciences. – 2013. – Vol. 9(5). – P. 435-443
7 Voytyuk, O.; Lennartsson, J.; Mogi, A.; Caruana, G.; Courtneidge,S.; Ashman, L. K.; Ronnstrand, L. Src family kinases are involved in the differential signaling from two splice forms of c-Kit // J. Biol.Chem. – 2003. – Vol. 278. – P. 9159-9166
8 Maulik, G.; Bharti, A.; Khan, E.; Broderick, R. J.; Kijima, T.;Salgia, R. Modulation of c-Kit/SCF pathway leads to alterations in topoisomerase-I activity in small cell lung cancer // J. Environ. Pathol. Toxicol. Oncol. – 2004. – Vol. 23. – P. 237-251
9 L. Rönnstrand Signal transduction via the stem cell factor receptor/c-Kit // СMLS, Cell. Mol. Life Sci. – 2004. – Vol. 61. – P. 2535–2548
10 Pawson T. Protein modules and signalling networks // Nature. – 1995. – Vol. 373. – P. 573-580
11 Blume-Jensen, P.; Rцnnstrand, L.; Gout, I.; Waterfield, M. D.; Heldin, C. Modulation of kit/stem cell factor receptor –induced signaling by protein kinase C // J. Biol. Chem. – 1994. – Vol. 269. – P. 21793- 21802
12 Huang, S.; Luca, M.; Gutman, M.; McConkey, D. J.; Langley, K. E.; Lyman, S. D.; Bar-Eli, M. Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential // Oncogene. – 1996. – Vol.13. – P. 2339-2347
13 Shen HQ, Tang YM, Yang SL, et al. Analysis of CD117 expression on leukemia cells // Chinese Journal of Hematology. – 2003. – Vol. 24(5). – P. 516-521
14 J. Lennartsson and L. Ronnstrand The Stem Cell Factor Receptor/c-Kit as a Drug Target in Cancer // Current Cancer Drug Targets. – 2006. –Vol.6. – P.561-571
15 Heinrich M, Blanke CD, Druker BJ, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies // J Clin Oncol. – 2002. – Vol. 20. – P. 1692-1703
16 Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor // Cancer Res. – 1996. – Vol. 56(2). – P.370-376
2 Chen SQ, Xiong AQ. The progress and implication of stem cell factor // Basic Medical Sciences and Clinics. – 2002. – Vol.22(5). – P. 385-390.
3 Antonescu CR. The GIST paradigm: lessons for other kinase-driven cancers // J Pathol. – 2011. – Vol. 223(2). – P. 251-261
4 Besmer P, Murphy JE, George PC, et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family // Nature. – 1986. – Vol. 320 (6061). – P.415-421
5 Lemmon MA, Ferguson KM. A new twist in the transmembrane signaling tool-kit // Cell. – 2007. – Vol. 130 (2). – P. 213-215
6 Jing Liang, Yan-Ling Wu, Bing-Jia Chen, Wen Zhang, Yoshimasa Tanaka and Hiroshi Sugiyama. The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases // International Journal of Biological Sciences. – 2013. – Vol. 9(5). – P. 435-443
7 Voytyuk, O.; Lennartsson, J.; Mogi, A.; Caruana, G.; Courtneidge,S.; Ashman, L. K.; Ronnstrand, L. Src family kinases are involved in the differential signaling from two splice forms of c-Kit // J. Biol.Chem. – 2003. – Vol. 278. – P. 9159-9166
8 Maulik, G.; Bharti, A.; Khan, E.; Broderick, R. J.; Kijima, T.;Salgia, R. Modulation of c-Kit/SCF pathway leads to alterations in topoisomerase-I activity in small cell lung cancer // J. Environ. Pathol. Toxicol. Oncol. – 2004. – Vol. 23. – P. 237-251
9 L. Rönnstrand Signal transduction via the stem cell factor receptor/c-Kit // СMLS, Cell. Mol. Life Sci. – 2004. – Vol. 61. – P. 2535–2548
10 Pawson T. Protein modules and signalling networks // Nature. – 1995. – Vol. 373. – P. 573-580
11 Blume-Jensen, P.; Rцnnstrand, L.; Gout, I.; Waterfield, M. D.; Heldin, C. Modulation of kit/stem cell factor receptor –induced signaling by protein kinase C // J. Biol. Chem. – 1994. – Vol. 269. – P. 21793- 21802
12 Huang, S.; Luca, M.; Gutman, M.; McConkey, D. J.; Langley, K. E.; Lyman, S. D.; Bar-Eli, M. Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential // Oncogene. – 1996. – Vol.13. – P. 2339-2347
13 Shen HQ, Tang YM, Yang SL, et al. Analysis of CD117 expression on leukemia cells // Chinese Journal of Hematology. – 2003. – Vol. 24(5). – P. 516-521
14 J. Lennartsson and L. Ronnstrand The Stem Cell Factor Receptor/c-Kit as a Drug Target in Cancer // Current Cancer Drug Targets. – 2006. –Vol.6. – P.561-571
15 Heinrich M, Blanke CD, Druker BJ, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies // J Clin Oncol. – 2002. – Vol. 20. – P. 1692-1703
16 Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor // Cancer Res. – 1996. – Vol. 56(2). – P.370-376
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Khamdiyeva О. K., Zakiryanova, G. K., & Biyasheva, Z. M. (2015). C-Kit proto-oncogene participation in tumor development. Experimental Biology, 60(1), 182–185. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/90
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Biomedicine
