The study of DNA repair gene XPD Lys751Gln polymorphism of population exposed to radiation;
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Keywords:
genetic bank, genetic polymorphism, DNA repair genes,Abstract
The aim of the study was to investigate the association of polymorphism of DNA reparation gene XPD Lys751Gln with individual radiosensitivity of people living in former Semey nuclear test site. Molecular genetics methods used to perform this task revealed XPD Lys751Gln genotypes among the two cohorts. It was shown that Lys751Lys variant was associated with individual radiosensitivity (OR=1.42).References
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2 Goode E. L., Ulrich C. M. and Potter J. D. Polymorphisms in DNA repair genes and associations with cancer risk //Cancer Epidemiol. Biomark. Prev. – 2002. – Р.1513-1530
3 Yuan H., Niu Y.M., Wang R.X. et al. Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis // Genet. Mol. Res. -2011. – V.10(4). – P.3356-3364.
4 Lunn R.M. et al. XPD polymorphisms: effect on DNA repair proficiency // Carcinogenesis. – 2000. – Vol. 21. – P. 551-555.
5 Zhou W, Liu G, Miller DP, et al. Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer // Cancer Res. – 2002. – Vol.62. – P.1377–1381
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Muratova, F. T., Nurzhibek, N., Zhunusbekova, B. B., Khussainova, E. M., Bekmanov, B. O., Djansugurova, L. B., & Bersimbay, R. I. (2015). The study of DNA repair gene XPD Lys751Gln polymorphism of population exposed to radiation;. Experimental Biology, 60(1), 142–145. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/76
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Biomedicine
