Ассоциация MLH1-93G>A полиморфизма с риском развития колоректального рака в казахстанской популяции. Қазақстандық популяциядағы колоректалды обыр дамуының MLH1-93G>A полиморфизмімен байланысы.
Ключевые слова:
колоректальный рак, MLH1-93G>A полиморфизм, колоректалды обыр, MLH1-93G>A полиморфизмі, казақстандық популяция, ПТР-РФПҰ,Аннотация
В статье приводятся результаты молекулярно-эпидемиологического исследования по выявлению ассоциации полиморфизма MLH1-93G>A (rs1800734) с развитием КРР у жителей г. Алматы. Генотипирование этого полиморфизма проведено у 247 больных колоректальным раком и 244 здоровых доноров. Статистический анализпозволил определить достоверную ассоциацию – 93GG генотипа с развитием колоректального рака у казахстанцев. Мақалада MLH1-93G>A (rs1800734) полиморфизмінің Алматы қаласы тұрғындарындағы колоректалды обыр дамуы арасындағы байланысын анықтау бойынша молекулалық-эпидемиологиялық зерттеулердің нәтижелері көрсетілген. Бұл полиморфизмді генотиптеу колоректалды обырмен ауыратын 247 науқастар мен 244 сау донорларға жүргізілді. Статистикалық талдау -93GG генотиптің қазақстандықтардағы колоректалды обырдың дамуымен нақты байланысын анықтауға мүмкіндік берді.Библиографические ссылки
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10 Muniz-Mendoza R., Ayala-Madrigal M.L., Partida-Perez M., et al., MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer // Genet Mol Res. -2012. – V. 11. – P. 2315-2320.
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12 Park S. H., Lee G. Y., Jeon H. S. et al., -93G-.A polymorphism of hMLH1 and risk of primary lung cancer // Int. J. Cancer. –2004. – V. 112. – P. 678–682.
13 Shih C. M., Chen C. Y., Lee I. H., Kao W. T., Wang Y. C., A polymorphism in the hMLH1 gene (-93G→A) associated with lung
cancer susceptibility and prognosis // Int. J. Mol. Med. – 2010. – V. 25. – P. 165–170.
14 Harley I., Rosen B., Risch H. A., et al., Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1 // Gynecol. Oncol. – 2008. – V. 109. – P. 384–387.
15 Beiner M. E., Rosen B., Fyles A., Harley I., Pal T., Siminovitch K., Zhang S., Sun, P. and Narod, S. A., Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2 // Cancer Epidemiol. Biomarkers Preven. – 2006. – V.15. – P. 1636–1640.
16 Deng D. J., Zhou J., Zhu B. D., Ji J. F., Harper J. C., Powell S. M., Silencing-specific methylation and single nucleotide polymorphism
of hMLH1 promoter in gastric carcinomas // World J. Gastroenterol. – 2003. – V. 9. – P. 26–29.
17 Lee K. M., Choi J. Y., Kang C. et al., Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk // Clin. Cancer Res. – 2005. – V. 11. – P. 4620–4626.
18 Jha R., Gaur P., Sharma S.C, Das S. N. Single nucleotide polymorphism in hMLH1 promoter and risk of tobacco-related oral
carcinoma in high-risk Asian Indians //Gene. – 2013. In print.
375 (9719). – P. 1030-1047.
2 Merika E., Saif M.W., Katz A., Syrigos K., Morse M., Review. Colon cancer vaccines: an update // In vivo (Athens, Greece). –2010. – V. 24 (5). – P. 607-628.
3 Malekzadeh R., Bishehsari F., Mahdavinia M., Ansari R., Epidemiology and molecular genetics of colorectal cancer in iran // A
review. Arch Iran Med, – 2009. – V. 12. – P. 161–169.
4 Jean M., Pelletier J., Hilpert M., Belzile F., Kunze R., Isolation and characterization of AtMLH1, a MutL homologue from Arabidopsis
thaliana // Mol Gen Genet. – 1999. V. 262. -P. 633–642.
5 Jiricny J., The multifaceted mismatch-repair system // Nat. Rev. Mol. Cell Biol. – 2006. – V. 7. – P. 335–346.
6 Hardman R.A., Afshari C.A., Barrett J.C., Involvement of ammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress // Cancer Res. – 2001. – V. 61. – P. 1392–1397.
7 Perera S., Mrkonjic M., Rawson J.B., Bapat B., Functional effects of the MLH1 −93G>A polymorphism on MLH1/EPM2AIP1 promoter activity // Oncol. Rep. – 2011. – V. 25. – P. 809–815.
8 Allan J. M., Shorto J., Adlard J. et al., MLH1 -93G.A promoter polymorphism and risk of mismatch repair deficient colorectal cancer // Int. J. Cancer. – 2008. V. 123. P. 2456–2459.
9 Raptis S. Mrkonjic M., Green R.C., et al., MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer // J Natl Cancer Inst. -2007. – V. 99, – P. 463-474.
10 Muniz-Mendoza R., Ayala-Madrigal M.L., Partida-Perez M., et al., MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer // Genet Mol Res. -2012. – V. 11. – P. 2315-2320.
11 Mohd Nizam Z., Abdul Aziz A. A., Gurjeet K., et al., Contribution of the MLH1 -93G>A Promoter Polymorphism in Modulating Susceptibility Risk in Malaysian Colorectal Cancer Patients // Asian Pacific J Cancer Prev. – 2013. – V. 14 (2), – P. 619-624.
12 Park S. H., Lee G. Y., Jeon H. S. et al., -93G-.A polymorphism of hMLH1 and risk of primary lung cancer // Int. J. Cancer. –2004. – V. 112. – P. 678–682.
13 Shih C. M., Chen C. Y., Lee I. H., Kao W. T., Wang Y. C., A polymorphism in the hMLH1 gene (-93G→A) associated with lung
cancer susceptibility and prognosis // Int. J. Mol. Med. – 2010. – V. 25. – P. 165–170.
14 Harley I., Rosen B., Risch H. A., et al., Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1 // Gynecol. Oncol. – 2008. – V. 109. – P. 384–387.
15 Beiner M. E., Rosen B., Fyles A., Harley I., Pal T., Siminovitch K., Zhang S., Sun, P. and Narod, S. A., Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2 // Cancer Epidemiol. Biomarkers Preven. – 2006. – V.15. – P. 1636–1640.
16 Deng D. J., Zhou J., Zhu B. D., Ji J. F., Harper J. C., Powell S. M., Silencing-specific methylation and single nucleotide polymorphism
of hMLH1 promoter in gastric carcinomas // World J. Gastroenterol. – 2003. – V. 9. – P. 26–29.
17 Lee K. M., Choi J. Y., Kang C. et al., Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk // Clin. Cancer Res. – 2005. – V. 11. – P. 4620–4626.
18 Jha R., Gaur P., Sharma S.C, Das S. N. Single nucleotide polymorphism in hMLH1 promoter and risk of tobacco-related oral
carcinoma in high-risk Asian Indians //Gene. – 2013. In print.
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