Myeloid-derived suppressor cells (MDSC) as a main tumor induced negative regulators of cancer immunity and possible ways for their elimination
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Keywords:
myeloid derived suppressor cells (MDSC), antitumor immunity, alpha-fetoprotei, .Abstract
Extremely increased immunosuppressive activity of myeloid derived suppressor cells (MDSC), a heterogeneous population of early myeloid precursors, is one of the main reasons for failure of the immune system, which includes natural killer cells, macrophages, dendritic cells and cytotoxic T lymphocytes, to inhibit tumor growth on the late stage of its development. MDSC suppress antitumor immunity and as a result significantly decrease the positive effect of anticancer immunotherapy. In this regard development of new approaches to effective elimination of MDSC from organisms that bear a growing tumor is an urgent problem of modern cancer immunology. Utilization of alphafetoprotein (AFP) as a vector molecule composed of cytotoxic conjugate, which is specifically recognized by MDSC receptors, for the purpose of their elimination and hereby activation of antitumor immunity is proposed.References
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ISSN 1563-0218 a KzNU Bulletin. Biology series. №1/1 (60). 2014
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// Science. – 2011. – V.331. – P. 1565-1570.
2 Cirri P., Chiarugi P. Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression // Cancer Metastasis Rev – 2012. – V.31. – N1-2. – P. 195-208.
3 Mulligan K.J., Young M.R.I. Tumors induce the formation of suppressor endothelial cells in vivo // Cancer Immunol. Immunother. – 2010. – V.59. – P. 267–277.
4 Quatromoni J.G., Eruslanov E. Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer // Am. J. Transl. Res. – 2012. – V.4. – N4. – P. 376-389.
5 Ma Y., Shurin G.V., Peiyuan Zh., Shurin M.R. Dendritic cells in the cancer microenvironment // J. Cancer. – 2013. – V.4. – N1. – P. 36-44.
6 Byrne W.L., Mills K.H.G., Lederer J.A., O’Sullivan G.C. Targeting regulatory T cells in cancer // Cancer Res. – 2011. – V.71. – P. 6915-6920.
7 Gabrilovich D.I., Ostrand-Rosenberg S. Bronte V. Coordinated regulation of myeloid cells by tumours // Nature Rev. Immunol. – 2012. -V.12. – P. 253-268.
8 Youn J.I., Nagaraj S., Collazo M., Gabrilovich D.I. Subsets of myeloid-derived suppressor cells in tumor-bearing mice // J. Immunol. – 2008. – V.181. – P. 5791-5802.
9 Greten T.F., Manns M.P., Korangy F. Myeloid derived suppressor cells in human diseases // International Immunopharmacology. – 2011. – V.11. – P. 802–807.
10 Forghani P., Khorramizadeh M.R., Waller E.K. Natural suppressor cells; past, present and future // Frontiers in Bioscience. – 2012. – E4. – P. 1237-1245.
11 BronteV., Wang M., Overwijk W.W., Surman D.R., Pericle F., Rosenberg S.A., Restifo N.P. Apoptotic death of CD8+ T lymphocytes
after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells // J. Immunol. – 1998. – V.161. – P. 5313–5320.
12 Gabrilovich D.I, Bronte V., Chen S.H., Colombo M.P., Ochoa A., Ostrand-Rosenberg S. The terminology issue for myeloidderived
suppressor cells // Cancer Res. – 2007. – V.67. – P. 425.
13 Peranzoni E., Zilio S., Marigo I., Dolcetti L., Zanovello P., Mandruzzato S., Bronte V. Myeloid-derived suppressor cell heterogeneity and subset definition // Curr. Opin. Immunol. – 2010. – V.22. – P. 238–244.
14 Kao J., Ko E.C., Eisenstein S., Sikora A.G., Fu S., Chen S.H. Targeting immune suppressing myeloid-derived suppressor cells in oncology // Crit. Rev. Oncol. Hematol. – 2011. – V.77. – P. 12-19.
15 Jacobs I., Bast R.C. Immunodiagnosis of germ cell tumors of the gonads. In: Herberman R.B., Mercer D.W., eds. Immunodiagnosis
of Cancer, New York, Marcel, Dekker. – 1990. – P. 323-338.
16 Mizejewski G.J. Biological roles of alpha-fetoprotein during pregnancy and perinatal development // Exp. Biol. Med. – 2004. – V.229. – P. 439-463.
17 Chakraborty M., Mandal C. Immuno-supressive effect of human alpha-fetoprotein: a cross species study // Immunol. Invest. – 1993. – V.22. – P. 329-339.
83
ISSN 1563-0218 a KzNU Bulletin. Biology series. №1/1 (60). 2014
N.N. Belyaev
18 Mizejewski G.J. Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family // Tumor Biol. – 2011. – V.32. – P. 241–258.
19 Богданов А.Ю., Саввулиди Ф.Г., Тлеулиева Р.Т., Беляев Н.Н. Альфа-фетопротеин как индуктор натуральных супрессорных (NS) клеток костного мозга. I. Изопикнические фракции NS-клеток и их супрессорные эффекты // Биотехнология. Теория и практика. – 2004. – №3. – С. 83-89.
20 Богданов А.Ю., Беляев Н.Н. Альфа-фетопротеин как индуктор натуральных супрессорных (NS) клеток костного мозга. II. Молекулярная природа супрессорных факторов // Биотехнология. Теория и практика. – 2004. – №3. – С. 90-98.
21 Belyaev N.N., Bogdanov A.Yu., Savvulidi Ph.G., Krasnoshtanov V.K., Tleulieva R.T., Alipov G.K., Sekine I., Bae J.S., Lee J.B., Min Y.K., Yang H.M. The influence of alpha-fetoprotein on natural suppressor cell activity and Ehrlich carcinoma growth // Korean J. Physiol. Pharmacol. – 2008. – V.12. – P. 193-197.
22 Богданов А.Ю. Молекулярные механизмы активации натуральных супрессорных клеток альфа-фетопротеином. Авто- реф. дисс. канд. биол. наук, Алматы, 2005, 22 с.
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Belyaev, N. N. (2015). Myeloid-derived suppressor cells (MDSC) as a main tumor induced negative regulators of cancer immunity and possible ways for their elimination. Experimental Biology, 60(1), 79–83. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/62
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