Interaction miRNA miR-1273 family with mRNA genes regulating cell cycle and apoptosis
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Keywords:
miRNA, gene, apoptosis, cell cycle, cancerAbstract
It was shown that genes involved in cell cycle regulation and apoptosis, are targets for the miR-1273 family. ATM, TP53 and VHL genes regulate the cell cycle and apoptosis and their mRNA have binding sites with miR-1273 family. CLSPN, MDM2, NF2, TRIM13 and LZTS1 genes proteins involved in cell cycle regulation and their mRNA are also targets for the majority of the studied miRNA. SPN, CASP, STK4 and DFFB genes participate in the regulation of apoptosis and they are targets for miR-1273 family. Studied miRNA under the appropriate concentrations can greatly affect the expression of genes involved in cell cycle regulation and apoptosis.References
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2 Luo Q., Li X., Li J., Kong X., Zhang J., Chen L., et al., MiR-15a is underexpressed and inhibits the cell cycle by targeting CCNE1 in breast cancer // Int J Oncol. – 2013. – Vol. 43. – P. 1212–1218.
3 Li X., Chen Y.T., Josson S., Mukhopadhyay N.K., Kim J., Freeman M.R., et al. MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells // PLoS One. – 2013. – Vol. 8. – P.e70987.
4 Qian N.S., Liu W.H., Lv W.P., Xiang X., Su M., Raut V., et al., Upregulated MicroRNA-92b regulates the differentiation and proliferation of EpCAM-positive fetal liver cells by targeting C/EBPß // PLoS One. – 2013. – Vol. 8. – P. e68004.
5 Cheng Q., Yi B., Wang A., Jiang X. Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis // Onco Targets Ther. – 2013. – Vol. 6. – P. 1675-1684.
6 Wang H., Zhu Y. et al. MiRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targetingintegrin β1 and matrix metalloproteinase2 (MMP2) // PLoS One. – 2013. – Vol.8. – e70192.
7 Zhong S., Li W., Chen Z., et al. MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells // Gene. – 2013.– S0378-1119(13)01122-0.
8 Cheng Q., Yi B., Wang A., Jiang X. Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis // Onco Targets Ther. – 2013. – Vol. 6. – P. 1675-84.
9 Берилло О.А., Иващенко А.Т., Пыркова А.Ю. и др. Особенности сайтов связывания miRNA семейства miR-1273 с mRNA генов человека // Вестник КазНУ серия биологическая. – 2013. – 3/1(59). – С. 251-256.
10 Nag S., Zhang X., Srivenugopal K.S., et al. Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet? // Curr Med Chem. – 2014. – Vol. 21. – 553-574.
11 Erkko H., Pylkäs K., Karppinen S.M., Winqvist R. Germline alterations in the CLSPN gene in breast cancer families // Cancer Lett. – 2008. – Vol. 261. – P. 93-97.
12 Hamaratoglu F., Willecke M., Kango-Singh M., et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis // Nat Cell Biol. – 2006. – Vol. 8. – P. 27-36.
13 Hatakeyama S. TRIM proteins and cancer // Nat Rev Cancer. – 2011. – Vol. 11. – P. 792-804.
14 Califano D., Pignata S., Pisano C., et al. FEZ1/LZTS1 protein expression in ovarian cancer // J Cell Physiol. – 2010. – Vol. 222. – P. 382-386.
15 Menkiszak J., Chudecka-Głaz A., Gronwald J., et al. Characteristics of selected clinical features in BRCA1 mutation carriers affected with breast cancer undergoing preventive female genital tract surgeries // Ginekol Pol. – 2013. – Vol. 84. – P. 758-764.
16 Maus M.K., Grimminger P.P., Mack P.C., et al. KRAS mutations in non-small-cell lung cancer and colorectal cancer: Implications for EGFR-targeted therapies // Lung Cancer. – 2013. – S0169-5002(13)00521-7.
17 Fu Q., Cash S.E., Andersen J.J., et al. CD43 in the nucleus and cytoplasm of lung cancer is a potential therapeutic target // Int J Cancer. – 2013. – Vol. 132. – P. 1761-1770.
18 Iglesias-Guimarais V., Gil-Guiñon E., Sánchez-Osuna M., et al. Chromatin collapse during caspase-dependent apoptotic cell death requires DNA fragmentation factor, 40-kDa subunit-/caspase-activated deoxyribonuclease-mediated 3’-OH single-strand DNA breaks // J Biol Chem. – 2013. – Vol. 288. – P. 9200-9215.
19 Xu C, Liu C, Huang W, et al. Effect of Mst1 overexpression on the growth of human hepatocellular carcinoma HepG2 cells and the sensitivity to cisplatin in vitro // Acta Biochim Biophys Sin (Shanghai). – 2013. – Vol. 45. – P. 268-279.
20 Khalil H.S., Tummala H., Chakarov S., et al. Targeting ATM pathway for therapeutic intervention in cancer // Biodiscovery. – 2012. – Vol. 1. – P. 3.
21 Zhou Q., Pardo A., Königshoff M., et al. Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis // FASEB J. – 2011. – Vol. 25. – P. 3032-3044.
22 Jiang P., Du W., Yang X. p53 and regulation of tumor metabolism // J Carcinog. – 2013. – Vol. 12. – P. 21.
23 Hsia TC, Tsai CW, Liang SJ, et al. Effects of ataxia telangiectasia mutated (ATM) genotypes and smoking habits on lung cancer risk in Taiwan // Anticancer Res. – 2013. – Vol. 33. – P. 4067-4071.
24 Hai Jiang H., Reinhardt C., Bartkova J., et al. The combined status of ATM and p53 link tumor development with therapeutic response // Genes & Dev. – 2009. – Vol. 23. – P. 1895-1909.
25 Zhou Q., Chen T., Ibe JC., et al. Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization // FEBS Lett. – 2012. – Vol.586. – P. 1510-1515.
26 Zia M.K., Rmali K.A., Watkins G., et al. The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells // Int J Mol Med. – 2007. – Vol.20. – P. 605-611.
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Ivashchenko, A. T., Atambayeva, S. A., & Niyazova, R. E. (2015). Interaction miRNA miR-1273 family with mRNA genes regulating cell cycle and apoptosis. Experimental Biology, 60(1), 13–17. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/46
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Bioinformatics, Genomics and Proteomics. Physical-chemical Biology
