Binding characteristics bta-miRNA with mRNA of MYB Bos taurus transcription factors family genes
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Keywords:
mRNA, miRNA, target genes, transcription factors,Abstract
The interaction 749 miRNA of Bos taurus genome with 20 MYB transcription factors family genes mRNA was studied. Installed 58 miRNA binding sites with eight MYB family gene mRNA. In mRNA each of the genes identified from three binding sites for gene MYBL1 to 21 binding sites for gene NCOR1. MiR-1260b had binding sites in mRNA MIER1, NCOR1, RCOR1 genes. Nine miRNA had binding sites in mRNA of two genes. The of ΔG / ΔGm value, characterizing the degree of affinity miRNA to mRNA, varied from 85 to 90%. The role of bta-miRNA in the regulation expression of MYB transcription factors target genes are discussed.References
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2 Matsuda A., Suzuki Y., Honda G. et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways // Oncogene. 2003. – Vol. 22. – P. 3307-3318.
3 Marhamati D.J., Bellas R.E., Arsura M. et al. A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase // Mol Cell Biol. – 1997. – Vol. 17. – P. 2448-2457.
4 Sitzmann J., Noben-Trauth K., Klempnauer K.H. Expression of mouse c-myb during embryonic development // Oncogene. –1995. – Vol. 11. – P. 2273-2279.
5 Oh I.H., Reddy E.P. The myb gene family in cell growth, differentiation and apoptosis // Oncogene. – 1999. – Vol. 18. – P.3017-3033.
6 Clements J.A., Mercer F.C., Paterno G.D., Gillespie L.L. Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells // PLoS One. – 2012.- Vol. 7. – P. 1371.
7 McCarthy PL, Mercer FC, Savicky MW. et al. Changes in subcellular localisation of MIER1 alpha, a novel oestrogen receptoralpha interacting protein, is associated with breast cancer progression // Br J Cancer. – 2008. – Vol. 99. – P. 639-646.
8 Andrejka L., Wen H., Ashton J. et al. Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex // Proc Natl Acad Sci U S A. – 2011.- Vol.108. – P. 17438-17443.
9 Shibata M., Nakao H., Kiyonari H. et al. MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors // J Neurosci. – 2011. – Vol.31. – P. 3407-3422.
10 Bari A.A., Orazova S.B., Ivashchenko A.T. miR156- and miR171-Binding Sites in the Protein-Coding Sequence of Some Plant Genes // BioMed Res. Int. – 2013. – Vol. 2013. – P. 1-7.
11 Сагайдак А.И., Пинский И.В., Иващенко А.Т., Ренье М., Бари А.А. Связывание miRNA с mRNA генов рост- регулирующих транскрипционных факторов арабидопсиса, риса и кукурузы // Вестник. Серия биологическая. – 2013. – Т. 3, № 59. – С. 289-292.
12 Choi H.K., Yoo J.Y., Jeong M.H. et al. Protein kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells // J Cell Physiol. – 2013. – Vol. 228. – P. 1159-1165.
13 Ali A.B., Nin D.S., Tam J., Khan M. Role of chaperone mediated autophagy (CMA) in the degradation of misfolded N-CoR protein in non-small cell lung cancer (NSCLC) cells // PLoS One. – 2011. – Vol. 6. – P. 268.
14 Zhang Z.H., Yamashita H., Toyama T. et al. Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse // Chin Med J (Engl). – 2009. – Vol. 122. – P. 1764-1768.
15 Abedin S.A., Thorne J.L., Battaglia S. et al. Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells // Carcinogenesis. – 2009. – Vol. 30. – P. 449-456.
16 Cowger J.J., Zhao Q., Isovic M., Torchia J. Biochemical characterization of the zinc-finger protein 217 transcriptional repressor
complex: identification of a ZNF217 consensus recognition sequence // Oncogene. – 2007. – Vol. 26. – P. 3378-3386.
17 Banck M.S., Li S., Nishio H. et al. The ZNF217 oncogene is a candidate organizer of repressive histone modifiers // Epigenetics.– 2009. – Vol. 4. – P.100-106.
18 Wang Y., Zhang H., Chen Y. et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer // Cell. – 2009. – Vol. 138. – P.660-672.
19 Kim S.S., Kim M.S., Yoo N.J., Lee S.H. Frameshift mutations of a chromatin-remodeling gene SMARCC2 in gastric and colorectal cancers with microsatellite instability // APMIS. – 2013. – Vol. 121. –P.168-169.
20 Moshkin Y.M., Mohrmann L., van Ijcken W.F., Verrijzer C.P. Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control // Mol Cell Biol. – 2007. – Vol. 27. – P. 651-661.
21 Inoue H., Giannakopoulos S., Parkhurst C.N., Matsumura T. et al. Target genes of the largest human SWI/SNF complex subunit control cell growth // Biochem J. – 2011. – Vol. 434. – P. 83-92.
22 Bochar D.A., Wang L., Beniya H. et al. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer // Cell. – 2000. – Vol. 102. – P. 257-265.
23 Nagl N.G., Patsialou A., Haines D.S. et al. The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes
is essential for normal cell cycle arrest // Cancer Res. – 2005. – Vol. 65. – P. 9236-9244.
24 Zu Y.F., Wang X.C., Chen Y., Wang JY. et al. Thyroid transcription factor 1 represses the expression of Ki-67 and induces apoptosis in non-small cell lung cancer // Oncol Rep. – 2012. – Vol. 28. – P. 1544-1550.
25 Galliani C.A., Bisceglia M., Lastilla G. et al. TTF-1 in embryonal tumors: an immunohistochemical study of 117 cases // Am J Surg Pathol. – 2011. – Vol. 35. – P. 1422-1425.
26 Fernández-Aceñero M.J., Córdova S., Manzarbeitia F., Medina C. Immunohistochemical profile of urothelial and small cell carcinomas of the bladder // Pathol Oncol Res. – 2011. – Vol. 17. – P. 519-523.
27 Yoon S.O., Kim Y.T., Jung K.C. et al. TTF-1 mRNA-positive circulating tumor cells in the peripheral blood predict poor prognosis in surgically resected non-small cell lung cancer patients // Lung Cancer. – 2011. – Vol. 71. – P. 209-216.
28 Ye J., Hameed O., Findeis-Hosey J.J. et al. Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung // Biotech Histochem. – 2012. – Vol. 87. – P. 30-34
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Ivashchenko, A. T., Аlybayeva A. Z., & Niyazova, R. E. (2015). Binding characteristics bta-miRNA with mRNA of MYB Bos taurus transcription factors family genes. Experimental Biology, 60(1), 5–8. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/44
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Bioinformatics, Genomics and Proteomics. Physical-chemical Biology
