Effect of alpha radiation from the decay of radon to lung cancer
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Keywords:
lung cancer, radon, mutation, KRAS.Abstract
In many countries, radon is the second leading cause of lung cancer, which accounts for 3% to 14% of cases. The paper presents the molecular genetic analysis of the KRAS gene in patients with lung cancer who live in Almaty, where the radon level exceeds the norm. Disorders in the studied gene lead to the development of many cancers. The analysis showed that examined patients don’t have a mutations in 12-13 codons of the KRAS gene, which corresponds tothe control group, consisting of 90 people. Perhaps this is dueto the small sample of the study group.References
Литература
1 Н.Г. Ригер, Ю.А. Зарипова, В.В. Дьячков, С.М. Тореханова, А.В. Юшков, Кастер, С.А. Ибрагимова. Сферосомы в качестве моделей биологических мембран при изучении воздействия альфа-излучения радона // Вестник КазНУ. Серия биологическая – 2014. - №1/1 (60). - С. 52-55.
2 Юшков А.В., Дьячков В.В. Ядерно-физические механизмы воздействия альфа-излучения радона на клетку и проблема онкозаболеваемости // Сборник научных трудов по материалам круглого стола «научные достижения в области экологии и охраны окружающей среды». – Алматы. - 2012. – С. 21-27.
3 James Milner, Clive Shrubsole, Payel Das, Benjamin Jones, Ian Ridley, Zaid Chalabi, Ian Hamilton, Ben Armstrong, Michael Davies and Paul Wilkinson Home energy efficiency and radon related risk of lung cancer: modelling study // BMJ. – 2014. – Vol. 348. - Published online Jan
4 Chen J., Moir D., and Whyte J. Canadian population risk of radon induced lung cancer: a re-assessment based on the recent cross-Canada radon survey // RadiatProt Dosimetry. - 2012. – Vol. 152. – P. 9–13.
5 X, Fan Y, Jiang Y, Xiang J, Wang J, Sun Z, Ren G, Yao S, Chang R, Zhao Y, Qiao Y, Zhou Q. A cohort study on risk factors of lung cancer in Yunnan tin miners // ZhongguoFei Ai ZaZhi. - 2013. – Vol.16 (4). – P. 184-90.
6 Forbes SA, Bindal N, Bamford S, et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer // Nucleic Acids Res. - 2011. – Vol.39 – P.945-950.
7 Kreuzer M. Dufey F. Laurier D. Nowak D. Marsh J. W. Schnelzer M. Sogl M. Walsh L.Mortality from internal and external radiation exposure in a cohort of male German uranium millers, 1946–2008 // Int Arch Occup Environ Health. – 2014.- Vol. 88. – P. 431–441.
8 Garassino MC, Marabese M, Rusconi P, et al. Different typesof KRAS as mutations could affect drug sensitivity and tumourbehaviour in non-small-cell lung cancer //Ann Oncol. - 2011. – Vol.22. – P.235-237.
References
1 Riger N.G., Zaripova Y.A., Dyachkov V.V., Torehanova S.M., Yushkov A.V., Kaster, Ibragimova S.A. Spherosomes as models of the biological membranes in the study of the effects of alpha radiation of radon isotopes // KazNU BULLETIN. Biology series – 2014. - №1/1 (60). - P. 52-55.
2 Yushkov A.V., Dyachkov V.V. Nuclear-physical mechanisms of action of alpha radiation on cells and radon problem oncological diseases // Collection of scientific papers on the materials of the round table "scientific achievements in the field of ecology and environmental protection." – Almaty. - 2012. – P. 21-27.
3 James Milner, Clive Shrubsole, Payel Das, Benjamin Jones, Ian Ridley, Zaid Chalabi, Ian Hamilton, Ben Armstrong, Michael Davies and Paul Wilkinson Home energy efficiency and radon related risk of lung cancer: modelling study // BMJ. – 2014. – Vol. 348. - Published online Jan
4 Chen J., Moir D., and Whyte J. Canadian population risk of radon induced lung cancer: a re-assessment based on the recent cross-Canada radon survey // RadiatProt Dosimetry. - 2012. – Vol. 152. – P. 9–13.
5 X, Fan Y, Jiang Y, Xiang J, Wang J, Sun Z, Ren G, Yao S, Chang R, Zhao Y, Qiao Y, Zhou Q. A cohort study on risk factors of lung cancer in Yunnan tin miners // ZhongguoFei Ai ZaZhi. - 2013. – Vol.16 (4). – P. 184-90.
6 Forbes SA, Bindal N, Bamford S, et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer // Nucleic Acids Res. - 2011. – Vol.39 – P.945-950.
7 Kreuzer M. Dufey F. Laurier D. Nowak D. Marsh J. W. Schnelzer M. Sogl M. Walsh L.Mortality from internal and external radiation exposure in a cohort of male German uranium millers, 1946–2008 // Int Arch Occup Environ Health. – 2014.- Vol. 88. – P. 431–441.
8 Garassino MC, Marabese M, Rusconi P, et al. Different typesof KRAS as mutations could affect drug sensitivity and tumourbehaviour in non-small-cell lung cancer //Ann Oncol. - 2011. – Vol.22. – P.235-237.
1 Н.Г. Ригер, Ю.А. Зарипова, В.В. Дьячков, С.М. Тореханова, А.В. Юшков, Кастер, С.А. Ибрагимова. Сферосомы в качестве моделей биологических мембран при изучении воздействия альфа-излучения радона // Вестник КазНУ. Серия биологическая – 2014. - №1/1 (60). - С. 52-55.
2 Юшков А.В., Дьячков В.В. Ядерно-физические механизмы воздействия альфа-излучения радона на клетку и проблема онкозаболеваемости // Сборник научных трудов по материалам круглого стола «научные достижения в области экологии и охраны окружающей среды». – Алматы. - 2012. – С. 21-27.
3 James Milner, Clive Shrubsole, Payel Das, Benjamin Jones, Ian Ridley, Zaid Chalabi, Ian Hamilton, Ben Armstrong, Michael Davies and Paul Wilkinson Home energy efficiency and radon related risk of lung cancer: modelling study // BMJ. – 2014. – Vol. 348. - Published online Jan
4 Chen J., Moir D., and Whyte J. Canadian population risk of radon induced lung cancer: a re-assessment based on the recent cross-Canada radon survey // RadiatProt Dosimetry. - 2012. – Vol. 152. – P. 9–13.
5 X, Fan Y, Jiang Y, Xiang J, Wang J, Sun Z, Ren G, Yao S, Chang R, Zhao Y, Qiao Y, Zhou Q. A cohort study on risk factors of lung cancer in Yunnan tin miners // ZhongguoFei Ai ZaZhi. - 2013. – Vol.16 (4). – P. 184-90.
6 Forbes SA, Bindal N, Bamford S, et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer // Nucleic Acids Res. - 2011. – Vol.39 – P.945-950.
7 Kreuzer M. Dufey F. Laurier D. Nowak D. Marsh J. W. Schnelzer M. Sogl M. Walsh L.Mortality from internal and external radiation exposure in a cohort of male German uranium millers, 1946–2008 // Int Arch Occup Environ Health. – 2014.- Vol. 88. – P. 431–441.
8 Garassino MC, Marabese M, Rusconi P, et al. Different typesof KRAS as mutations could affect drug sensitivity and tumourbehaviour in non-small-cell lung cancer //Ann Oncol. - 2011. – Vol.22. – P.235-237.
References
1 Riger N.G., Zaripova Y.A., Dyachkov V.V., Torehanova S.M., Yushkov A.V., Kaster, Ibragimova S.A. Spherosomes as models of the biological membranes in the study of the effects of alpha radiation of radon isotopes // KazNU BULLETIN. Biology series – 2014. - №1/1 (60). - P. 52-55.
2 Yushkov A.V., Dyachkov V.V. Nuclear-physical mechanisms of action of alpha radiation on cells and radon problem oncological diseases // Collection of scientific papers on the materials of the round table "scientific achievements in the field of ecology and environmental protection." – Almaty. - 2012. – P. 21-27.
3 James Milner, Clive Shrubsole, Payel Das, Benjamin Jones, Ian Ridley, Zaid Chalabi, Ian Hamilton, Ben Armstrong, Michael Davies and Paul Wilkinson Home energy efficiency and radon related risk of lung cancer: modelling study // BMJ. – 2014. – Vol. 348. - Published online Jan
4 Chen J., Moir D., and Whyte J. Canadian population risk of radon induced lung cancer: a re-assessment based on the recent cross-Canada radon survey // RadiatProt Dosimetry. - 2012. – Vol. 152. – P. 9–13.
5 X, Fan Y, Jiang Y, Xiang J, Wang J, Sun Z, Ren G, Yao S, Chang R, Zhao Y, Qiao Y, Zhou Q. A cohort study on risk factors of lung cancer in Yunnan tin miners // ZhongguoFei Ai ZaZhi. - 2013. – Vol.16 (4). – P. 184-90.
6 Forbes SA, Bindal N, Bamford S, et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer // Nucleic Acids Res. - 2011. – Vol.39 – P.945-950.
7 Kreuzer M. Dufey F. Laurier D. Nowak D. Marsh J. W. Schnelzer M. Sogl M. Walsh L.Mortality from internal and external radiation exposure in a cohort of male German uranium millers, 1946–2008 // Int Arch Occup Environ Health. – 2014.- Vol. 88. – P. 431–441.
8 Garassino MC, Marabese M, Rusconi P, et al. Different typesof KRAS as mutations could affect drug sensitivity and tumourbehaviour in non-small-cell lung cancer //Ann Oncol. - 2011. – Vol.22. – P.235-237.
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How to Cite
Biyasheva, Z. M., Khamdiyeva, O. K., Dyachkov, V. V., Zaripova, Y. A., & Yushkov, A. V. (2016). Effect of alpha radiation from the decay of radon to lung cancer. Experimental Biology, 65(3), 118–123. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/1105
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МOLECULAR BIOLOGY AND GENETICS
