Участие C-Kit протоонкогена в развитии опухоли. C-Kit протоонкогенінің ісiк дамуына қатысуы
Ключевые слова:
протоонкоген с-Kit, лиганд c-Kit (Stem cell factor – SCF), пролиферация, онкология, терапия,Аннотация
Приведен обзор литературы по вопросам взаимосвязи протоонкогена C-Kit с индукцией опухоли. В экспериментальных статьях показано, что C-Kit играет ключевую роль в возникновении опухоли. Мутации в этомгене вызывают специфическую экспрессию определенных генов, нарушают регуляцию клеточной дифференцировки, пролиферации и препятствуют клеточному апоптозу. Была обоснована ведущая роль с-Kit в развитии опухоли, что позволяет использовать его в качестве мишени в терапии рака. C-Kit протоонкогені iсiк индукциясымен байланысу сұрақтарына арналған әдебиеттер шолуы келтiрiлген. C-Kit iсiк пайда болуында маңызды рөл ойнайтынын эксперименталдi мақалаларда көрсетілген. Бұл геннің мутациялары нақтылы гендердiң ерекше кспрессияларына келтіреді, жасушалар дифференциасының регуляциясын, пролиферацияны бұзады және жасушалар апоптозына кедергi келтiредi. С-Kit iсiк дамуындағы жетекшi рөлі дәлелдеген, бұл оны обырдың терапиясында нысана ретінде пайдалануға мүмкiндiк ереді.Библиографические ссылки
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15 Heinrich M, Blanke CD, Druker BJ, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies // J Clin Oncol. – 2002. – Vol. 20. – P. 1692-1703
16 Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor // Cancer Res. – 1996. – Vol. 56(2). – P.370-376
2 Chen SQ, Xiong AQ. The progress and implication of stem cell factor // Basic Medical Sciences and Clinics. – 2002. – Vol.22(5). – P. 385-390.
3 Antonescu CR. The GIST paradigm: lessons for other kinase-driven cancers // J Pathol. – 2011. – Vol. 223(2). – P. 251-261
4 Besmer P, Murphy JE, George PC, et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family // Nature. – 1986. – Vol. 320 (6061). – P.415-421
5 Lemmon MA, Ferguson KM. A new twist in the transmembrane signaling tool-kit // Cell. – 2007. – Vol. 130 (2). – P. 213-215
6 Jing Liang, Yan-Ling Wu, Bing-Jia Chen, Wen Zhang, Yoshimasa Tanaka and Hiroshi Sugiyama. The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases // International Journal of Biological Sciences. – 2013. – Vol. 9(5). – P. 435-443
7 Voytyuk, O.; Lennartsson, J.; Mogi, A.; Caruana, G.; Courtneidge,S.; Ashman, L. K.; Ronnstrand, L. Src family kinases are involved in the differential signaling from two splice forms of c-Kit // J. Biol.Chem. – 2003. – Vol. 278. – P. 9159-9166
8 Maulik, G.; Bharti, A.; Khan, E.; Broderick, R. J.; Kijima, T.;Salgia, R. Modulation of c-Kit/SCF pathway leads to alterations in topoisomerase-I activity in small cell lung cancer // J. Environ. Pathol. Toxicol. Oncol. – 2004. – Vol. 23. – P. 237-251
9 L. Rönnstrand Signal transduction via the stem cell factor receptor/c-Kit // СMLS, Cell. Mol. Life Sci. – 2004. – Vol. 61. – P. 2535–2548
10 Pawson T. Protein modules and signalling networks // Nature. – 1995. – Vol. 373. – P. 573-580
11 Blume-Jensen, P.; Rцnnstrand, L.; Gout, I.; Waterfield, M. D.; Heldin, C. Modulation of kit/stem cell factor receptor –induced signaling by protein kinase C // J. Biol. Chem. – 1994. – Vol. 269. – P. 21793- 21802
12 Huang, S.; Luca, M.; Gutman, M.; McConkey, D. J.; Langley, K. E.; Lyman, S. D.; Bar-Eli, M. Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential // Oncogene. – 1996. – Vol.13. – P. 2339-2347
13 Shen HQ, Tang YM, Yang SL, et al. Analysis of CD117 expression on leukemia cells // Chinese Journal of Hematology. – 2003. – Vol. 24(5). – P. 516-521
14 J. Lennartsson and L. Ronnstrand The Stem Cell Factor Receptor/c-Kit as a Drug Target in Cancer // Current Cancer Drug Targets. – 2006. –Vol.6. – P.561-571
15 Heinrich M, Blanke CD, Druker BJ, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies // J Clin Oncol. – 2002. – Vol. 20. – P. 1692-1703
16 Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor // Cancer Res. – 1996. – Vol. 56(2). – P.370-376
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