C-Kit proto-oncogene participation in tumor development

Abstract

The literature on the proto-oncogene C-Kit binding with the induction of tumor is given. In experimental papers is shown that C-Kit plays a main role in the tumor occurrence. Mutations in this gene cause specific expression of certain genes, disrupt the regulation of cellular differentiation, proliferation and inhibit cellular apoptosis. The leading role of c-Kit in the development of tumors was explained, it can be used as a target in cancer therapy.