Сайты связывания miRNA-маркеров рака молочной железы. Сүт безі обырының miRNA-маркерларындағы байланысу сайттары
Ключевые слова:
miRNA, рак молочной железы, маркер, сүт безінің обыры, miR-665, miR-4417.Аннотация
1300 абстрактов статей, посвященных поиску маркерных miRNAдля диагностики рака молочной железы, обработаны с помощью скрипта miRCancer. Проведен поиск сайтов связывания 357 miRNA в mRNA 427 генов, белки которых участвуют в онкогенезе молочной железы. Используя программу MirTarget отобраны сайты связывания miRNA в 5’UTR, CDS, 3’UTR mRNA со свободной энергией гибридизации равной 90% и более. Нами выявлено, что miR-665 и miR-4417 являются перспективными маркерами для диагностики рака молочной железы. Сүт безінің обыры диагностикасын жүргізу үшін miRCancer скриптін қолданып 1300 мақалалардың абстракттары қарастырылған. 357 miRNA-дың 427 гендердің mRNA байланысу сайттарына іздестіру жүргізілген. Бұл гендердің ақуыздары сүт безінің онкогенезіне қатысады. MirTarget бағдарламасын қолданып mRNA 5’UTR, CDS, 3’UTR бос гибридизация энергиясы 90% жоғары сайттар анықталған. miR-665 және miR-4417 сүт безінің диагностикасын өткізу үшін перспективті маркерлар болатындығы анықталдыБиблиографические ссылки
1 Jochelson M., Hayes D.F., Ganz P.A. Surveillance and monitoring in breast cancer survivors: maximizing benefit and minimizing harm // Am. Soc. Clin. Oncol. Educ. Book. 2013. – Vol.12. – P. 13–18.
2 Eberts E.M. The early diagnosis of cancer of the breast // Can. Med. Assoc J. 1934. – Vol. 31. – No. 1. – P. 9–14.
3 Simon K. Studies of diagnosis and prognosis of breast carcinoma from serum findings // Med. Monatsschr.1957. – Vol. 11. – No.12. – P. 794–800.
4 Iorio M.V., Ferracin M., Liu C.G., Veronese A., Spizzo R., Sabbioni S. et al. MicroRNA gene expression deregulation in human breast cancer // Cancer Res. 2005. – Vol. 65. – No. 16. – P. 7065–7070.
5 Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs // Science. 2001. – Vol. 294. – No. 5543. – P. 853–858.
6 Ramalingam P., Palanichamy J.K., Singh A., Das P., Bhagat M., Kassab M.A. et al. Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing // RNA. 2014. – Vol. 20. – No. 1. – P. 76–87.
7 Si H., Sun X., Chen Y., Cao Y., Chen S., Wang H., Hu C. Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer // J. C. Res. Clin. Oncol. 2013. – Vol. 139. – No. 2. – P. 223–229.
8 Murria E.R., Palanca S.S., de Juan J.I., Egoavil R.C., García-Casado Z., Juan F.M. et al. MicroRNA signatures in hereditary breast cancer // J. Breast C. Res. Treat. 2013. – Vol. 142. – No. 1. – P. 19–30.
9 Borgan E., Navon R., Vollan H.K., Schlichting E., Sauer T., Yakhini Z. et al. Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue // Mol. Oncol. 2011. – Vol. 5. – No. 6. – P. 564–576.
10 Addou-Klouche L., Adélaïde J., Cornen S., Bekhouche I., Finetti P., Guille A. et al. Integrated genomic analysis of breast cancers // Balk. J. Med. Genet. 2012. – Vol. 15. – P. 71–74.
11 Li Q., Li X., Guo Z., Xu F., Xia J., Liu Z. et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer // PLoS One. 2012. – Vol. 7. – No. 11. – P. 48278.
12 Yang M., Liu R., Sheng J., Liao J., Wang Y., Pan E. et al. Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma // Oncol. Rep. 2013. – Vol. 29. – No. 1. – P. 169–176.
13 Ji S., Ye G., Zhang J., Wang L., Wang T., Wang Z. et al. miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer // Gut. 2013. – Vol. 62. – No. 5. – P. 716–726.
14 Fan M., Li X., Jiang W., Huang Y., Li J., Wang Z. A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells // Exp. Ther. Med. 2013. – Vol. 5. – No. 4. – P. 1143–1146.
15 Guo L.H., Li H., Wang F., Yu J., He J.S. The Tumor suppressor roles of miR-433 and miR-127 in gastric cancer // Int. J. Mol. Sci. 2013. – Vol. 14. – P. 14171–14184.
2 Eberts E.M. The early diagnosis of cancer of the breast // Can. Med. Assoc J. 1934. – Vol. 31. – No. 1. – P. 9–14.
3 Simon K. Studies of diagnosis and prognosis of breast carcinoma from serum findings // Med. Monatsschr.1957. – Vol. 11. – No.12. – P. 794–800.
4 Iorio M.V., Ferracin M., Liu C.G., Veronese A., Spizzo R., Sabbioni S. et al. MicroRNA gene expression deregulation in human breast cancer // Cancer Res. 2005. – Vol. 65. – No. 16. – P. 7065–7070.
5 Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs // Science. 2001. – Vol. 294. – No. 5543. – P. 853–858.
6 Ramalingam P., Palanichamy J.K., Singh A., Das P., Bhagat M., Kassab M.A. et al. Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing // RNA. 2014. – Vol. 20. – No. 1. – P. 76–87.
7 Si H., Sun X., Chen Y., Cao Y., Chen S., Wang H., Hu C. Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer // J. C. Res. Clin. Oncol. 2013. – Vol. 139. – No. 2. – P. 223–229.
8 Murria E.R., Palanca S.S., de Juan J.I., Egoavil R.C., García-Casado Z., Juan F.M. et al. MicroRNA signatures in hereditary breast cancer // J. Breast C. Res. Treat. 2013. – Vol. 142. – No. 1. – P. 19–30.
9 Borgan E., Navon R., Vollan H.K., Schlichting E., Sauer T., Yakhini Z. et al. Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue // Mol. Oncol. 2011. – Vol. 5. – No. 6. – P. 564–576.
10 Addou-Klouche L., Adélaïde J., Cornen S., Bekhouche I., Finetti P., Guille A. et al. Integrated genomic analysis of breast cancers // Balk. J. Med. Genet. 2012. – Vol. 15. – P. 71–74.
11 Li Q., Li X., Guo Z., Xu F., Xia J., Liu Z. et al. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer // PLoS One. 2012. – Vol. 7. – No. 11. – P. 48278.
12 Yang M., Liu R., Sheng J., Liao J., Wang Y., Pan E. et al. Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma // Oncol. Rep. 2013. – Vol. 29. – No. 1. – P. 169–176.
13 Ji S., Ye G., Zhang J., Wang L., Wang T., Wang Z. et al. miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer // Gut. 2013. – Vol. 62. – No. 5. – P. 716–726.
14 Fan M., Li X., Jiang W., Huang Y., Li J., Wang Z. A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells // Exp. Ther. Med. 2013. – Vol. 5. – No. 4. – P. 1143–1146.
15 Guo L.H., Li H., Wang F., Yu J., He J.S. The Tumor suppressor roles of miR-433 and miR-127 in gastric cancer // Int. J. Mol. Sci. 2013. – Vol. 14. – P. 14171–14184.
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Биоинформатика, геномика и протеомика. Физико-химическая биология
