GLY-934 ОБЕСПЕЧИВАЕТ ВЗАИМОДЕЙСТВИЕ РИКТОРА С SIN1
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Keywords:
mTOR, kinase,Abstract
mTOR (mammalian target of rapamycin) is an important hub kinase of growth factor and nutrient signaling. Functioning as a part of two distinct multiprotein complexes - mTORC1 and mTORC2 (mTOR complexes 1 and 2) – it regulates cell growth and proliferation. We have established that Gly-934 residue of mTORC2’s rictor plays a key role in maintaining rictor-Sin1 interaction.References
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2. Chen C.-H., Shaikenov T., Aimbetov R., Peterson T.R., Bissenbaev A.K., Lee S.-W., Wu J., Lin H.-K., Sarbassov D.D. ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor // Science Signaling. - 2011. -Vol.4(161). - P.ra10.
3. Kannan N., Haste N., Taylor S.S., Neuwald A.F. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module // Proc Natl Acad Sci USA. - 2007. - Vol.104(4). - P.1272-7.
4. Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex // Science. - 2005. - Vol.307. - P.1098–1101.
5. Jones K.T., Greer E.R., Pearce D., Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1 // PLoS Biol. - 2009. - Vol.7. - P.0604-0615.
6. Soukas A.A., Kane E.A., Carr C.E., Melo J.A., Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans // Genes Dev. - 2009. - Vol.23. - P.496-511.
7. Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton // Curr Biol. - 2004. - Vol.14. - P.1296–1302.
8. Martín de Llano J.J., Fuertes G., Andreu E.J., Puig O., Chaves F.J., Soutar A.K., Armengod M.E., Knecht E. A single point mutation in the low-density lipoprotein receptor switches the degradation of its mature protein from theproteasome to the lysosome // Int J Biochem Cell Biol. - 2006. - Vol.38(8). - P.1340-51.
2. Chen C.-H., Shaikenov T., Aimbetov R., Peterson T.R., Bissenbaev A.K., Lee S.-W., Wu J., Lin H.-K., Sarbassov D.D. ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor // Science Signaling. - 2011. -Vol.4(161). - P.ra10.
3. Kannan N., Haste N., Taylor S.S., Neuwald A.F. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module // Proc Natl Acad Sci USA. - 2007. - Vol.104(4). - P.1272-7.
4. Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex // Science. - 2005. - Vol.307. - P.1098–1101.
5. Jones K.T., Greer E.R., Pearce D., Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1 // PLoS Biol. - 2009. - Vol.7. - P.0604-0615.
6. Soukas A.A., Kane E.A., Carr C.E., Melo J.A., Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans // Genes Dev. - 2009. - Vol.23. - P.496-511.
7. Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton // Curr Biol. - 2004. - Vol.14. - P.1296–1302.
8. Martín de Llano J.J., Fuertes G., Andreu E.J., Puig O., Chaves F.J., Soutar A.K., Armengod M.E., Knecht E. A single point mutation in the low-density lipoprotein receptor switches the degradation of its mature protein from theproteasome to the lysosome // Int J Biochem Cell Biol. - 2006. - Vol.38(8). - P.1340-51.
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How to Cite
Аимбетов, Р. С., Бисенбаев, А. К., & Сарбасов, Д. Д. (2017). GLY-934 ОБЕСПЕЧИВАЕТ ВЗАИМОДЕЙСТВИЕ РИКТОРА С SIN1. Experimental Biology, 56(4), 145–150. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/374
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BIOTECHNOLOGY
