Influence of ouabaine on the contents of P-selectin on the surface of the neurovascular endotheliocytes when exposed to β-Amyloid
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Keywords:
ouabaine, P-selectin, neurovascular endotheliocytes of rat brain,Abstract
Infl uence of ouabain to the P-selectin expression on the surface of neurovascular endotheliocytes under exposure of amyloid- β was investigated in this research. It was shown that ouabain activate endocytosis and regulate amount of Pselectin on the cell surface.References
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2 Bradbury M.W. The blood-brain barrier. Transport across the cerebral endothelium // Circ Res. -1985. - V. 57. - P. 213-222.
3 Frijns C.J., Kappelle L.J. Infl ammatory cell adhesion molecules in ischemic cerebrovascular disease // Stroke. - 2002. - V. 33. – P. 2115-2122.
4 Coisne C., Faveeuw C., Delplace Y., Dehouck L., Miller F., Cecchelli R., Dehouck B. Differential expression of selectins by mouse brain capillary endothelial cells in vitro in response to distinct infl ammatory stimuli // Neurosci Letters. - 2006. V. 392 - P.216-220.
5 Jiang L., Man L., Lijun L., Deepak M., Zijian X., Shapiro J. I. Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells
requires caveolin-1 // Kidney International. - 2005. -67(5). - P. 1844-1854.
6 Corley C., David M. S. and Murphy R. F. Regulation of endocytic pH by the Na’,K+-ATPase in living cells // Proc. Natl. Acad. Sci. - 1989. - V. 86. - P.544-548.
7 Nesher M., Shpolansky U., Viola N., Dvela M., Buzaglo N., Cohen Ben-Ami H. Ouabain attenuates cardiotoxicity induced by other cardiac steroids // British Journal of Pharmacology. - 2010. - V. 10. - P.
1476-1481.
8 Joubin K., Richardson A., Novoa N., Tu E., and J. Tomishima M. The endothelial cell line bend.3 maintains human pluripotent stem cells // Stem. Cells Dev. - 2012. – V.122. - P.1211-1224.
9 Fa M., Orozco I.J., Francis Y.I., Saeed F., Gong Y., Arancio O. Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices // J. Vis. Exp. - 2010. -
V.14(41). - P.1884.
10 Nunez-Duran H., Riboni L., Ubaldo E., Kabela E., Barcenas-Ruiz L. Ouabain uptake by endocytosis in isolated guinea pig atria // Am. J. Physiol. - 1988. - V. 255. - P. 479-485.
11 Small A., McElroy H.W., Ide R.S. Studies of the electrocardiogram and the toxicity of cardiac glycosides in animals exposed to hyperbaric helium // Toxicol Appl. Pharmacol. - 1971. - V.20. - P. 44-56.
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Tsoy, A. K., Shalahmetova, T. M., Askarova, S. Y., & Umbayev, B. A. (2015). Influence of ouabaine on the contents of P-selectin on the surface of the neurovascular endotheliocytes when exposed to β-Amyloid. Experimental Biology, 54(2), 61–63. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/262
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HISTOLOGY, CYTOLOGY, CELL BIOLOGY
