A cytogenetic study of the antimutagenic potential of herbal infusions from Matricaria chamomilla L. and Achillea millefolium L. (Fam. Asteraceae)
DOI:
https://doi.org/10.26577/eb-2019-4-b5Abstract
Due to increase of hazardous factors in the environment, it becomes relevant to search for effective protectors of natural origin for the correction of toxic and genetic effects induced by xenobiotics. Using the test for count chromosomal abnormalities in cells of root germinal meristem of barley seeds, the mutagenic and antimutagenic activity of infusions from chamomile (Matricaria chamomilla) and yarrow (Achillea millefolium) were studied. The studied infusions with various preparation methods (concentrated, diluted and phyto tea) did not show mutagenic activity. The frequency of structural mutations was at the level of negative control (distilled water). The ability of yarrow and chamomile infusions to reduce MMS-induced mutagenesis has been established. For direct and reverse treatment of seeds with diluted infusions or herbal tea of medicinal plants and mutagen methyl methanesulfonate (MMS, positive control) a statistically significant decrease of MMS-induced was observed (p<0.05). Moreover, the level of inhibition of the mutation process depended on the sequence of exposure to infusions and mutagen, as well as the type of infusion. The effectiveness of the antimutagenic effect of the studied infusions was evaluated by the reduction factor. The reduction factor in the infusion of diluted chamomile and chamomile tea was 67.0% and 62.0%, respectively, which indicates the ability to inhibit MMS-induced mutagenesis by more than 60% from Matricaria chamomilla infusions. The results indicate a strong antimutagenic effect of diluted infusions of chamomile. The magnitude of the reduction factor in yarrow infusions indicates the ability of infusions from Achillea millefolium to inhibit MMS-induced mutagenesis by 40-50% with preliminary exposure to barley to MMS. The reduction factor subsequent to the effect of infusions after MMS was 45-50%. The results obtained indicate the presence of antimutagenic activity in infusions of chamomile and yarrow, due to the presence of biologically active substances of various nature in plants of these species.
Key words: biologically active substances, medicinal plants, mutagenesis, antimutagenic activity, chromosomal aberrations.
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4. Carpenter D.O., Bushkin-Bedient Sh. Exposure to Chemicals and Radiation During Childhood and Risk for Cancer Later in Life // Journal of Adolescent Health. – 2013. – Vol. 52. – Р. S21-S29.
5. Lovinskaya A.V., Kolumbayeva S.Zh., Shalakhmetova T.M., Marsova M.V., Abilev S.K. Antigenotoxic Activity of Biologically Active Substances from Inula britannica and Limonium gmelini // Russian Journal of Genetics. – 2017. - Vol. 53, No. 12. – Р. 1311–1319.
6. Дурнев А.Д. Методические аспекты исследований по модификации химического мутагенеза // Бюллетень экспериментальной биологии и медицины. - 2008. - Т. 146, № 9. - С. 281-287.
7. Uzun F., Kalender S., Durak D., Demir F., Kalender Y. Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E // Food and Chemical Toxicology. - 2009. - Vol. 47, № 8. - P. 1903-1908.
8. Słoczyńska K., Powroźnik B., Pękala E., Waszkielewicz A.M. Antimutagenic compounds and their possible mechanisms of action // J Appl Genetics. - 2014. - Vol. 55, № 2. - P. 273–285.
9. Chen K.-H., Wang, K.-J., WangK.-M., Angelia M.-A. Applying Particle Swarm Optimization-Based Decision Tree Classifier for Cancer Classification on Gene Expression Data // Applied Soft Computing. - 2014. – Vol. 24. – Р. 773-780
10. Колумбаева С.Ж., Ловинская А.В., Жусупова А.И., Рахимжанова А.А., Илиясова А.И., Муратова А.Т. Токсическая и мутагенная активность биологически активных веществ из растений Limonium gmelinii семейства Plumbaginaceae (= Limoniaceae Lincz.) // Вестник КазНУ. Серия биологическая. - 2016. - Т. 66, № 1. - С. 144-153.
11. Лосева И.В. Сырьевая база лекарственных растений Казахстана и ее рациональное использование: Учебно-методическое пособие. – Караганда. - 2008. - 110 с.
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13. Нестерова С.Г., Инелова З.А., Ерубаева Г.К., Запарина Е.Г., Сeйткадыр К.А. Материалы к оценке разнообразия семейства Caryophyllaceae Juss Заилийского Алатау // Вестник КазНУ. Серия биологическая. – 2016. – Т. 68, №3. – С. 16-23.
14. Lakshman H., Yeasmin T., Gabriel K. Herbs of Asteraceae and their ethano medicinal uses in dermatological problems // Journal of Bio-Science. – 2016. – Vol.22. – P. 127-129.
15. Georgieva M., Gecheff K. Molecular Cytogenetic Characterizationofa New Reconstructed Barley Karyotype // Biotechnology & Biotechnological Equipment. – 2013. - Vol. 27, № 1. - P. 3577-3582.
16. Sharifi H., Minaie M.B., Qasemzadeh M.J., Ataei N., Gharehbeglou M., Heydari M. Topical use of Matricaria recutita L (Chamomile) Oil in the Treatment of Monosymptomatic Enuresis in Children: A Double-Blind Randomized Controlled Trial // J Evid Based Complementary Altern Med. – 2017. – Vol. 22, № 1. – P. 12-17
17. Hashempur M.H., Lari Z.N., Ghoreishi P.S., Daneshfard B., Ghasemi M.S., Homayouni K., Zargaran A. A pilot randomized double-blind placebo-controlled trial on topical chamomile (Matricaria chamomilla L.) oil for severe carpal tunnel syndrome // Complement Ther Clin Pract. – 2015. – Vol. 21, № 4. – P. 223-228
18. Покровская И.С., Мазова О.В., Апыхтин Н.Н., Племенков В.В. Хемотаксономия тысячелистника обыкновенного (Achillea millefolium l) // Химия растительного сырья. - 2009. - №3. – С. 85-88.
19. Oshida K., Iwanaga E., Miyamoto K., Miyamoto Y. Comet assay in murine bone-marrow cell line (FDC-P2) // Toxicol. in Vitro. - 2010. - Vol. 24, N 3. - P1039-1044.
20. Smirnikhina S.A., Strelnikov V.V., Voronina E.S., Tanas A.S., Lavrov A.V. Mutagen influence with different mechanisms of action on DNA global methylation in human whole-blood lymphocytes in vitro // Russian journal of genetics. – 2013. - Vol.49, №7. – Р. 765-770
21. Паушева З.П. Практикум по цитологии растений. – М.: Агропромиздат, 1988. – 271 с.
22. Даев Е.В., Дукельская А.В., Барабанова Л.В. Цитогенетические методы индикации экологической напряженности в водных и наземных биосистемах // Экологическая генетика. – 2014. – Т.12, №2. – С. 3-12.
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Kolumbayeva, S. Z., Lovinskaya, A. V., Iliyassova, A. I., Adybayeva, A. T., & Abilev, S. K. (2020). A cytogenetic study of the antimutagenic potential of herbal infusions from Matricaria chamomilla L. and Achillea millefolium L. (Fam. Asteraceae). Experimental Biology, 81(4), 43–54. https://doi.org/10.26577/eb-2019-4-b5
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МOLECULAR BIOLOGY AND GENETICS
