ANTIGENOTOXIC EFFECT FROM HERBAL TEA OF ELECAMPANE (INULA HELENIUM L.) ROOTS AND RHIZOMES
Keywords:
genotoxicity, antimutagen, Comet assay, rocket propellant, elecampane.Abstract
Genotoxic and antigenotoxic properties of herbal tea of Elecampane (Inula helenium L.) roots and rhizomes were studied. Using Comet assay method it was found that unsymmetrical dimethylhydrazine at a dose of 6.6 mg/kg caused DNA single-strand breaks in cells from different tissues of mice with frequency significantly exceeding the spontaneous level. Elecampane tincture at 600.0 mg/kg showed no mutagenic activity in laboratory animals, the frequency of DNA strand breaks was on the control level. But when combined with unsymmetrical dimethylhydrazine it substantially reduced mutagenic effect of the xenobiotic. Level of DNA strand breaks in cells of all the internal organs of mice was significantly decreased in a combined application of usymmetrical dimethylhydrazine with herbal tea. The results indicate the presence of antigenotoxic properties of herbal tea of elecampane roots and rhizomes.References
Литература
1 База данных Chemical Abstracts Service (CAS) - https://www.cas.org/.
2 Курляндский Б.А., Филов В.А. (ред.) Общая токсикология. - М.: Медицина, 2002. — 608 с.
3 Carlsen L., Nauryzbaev M., Kenesova O., Batyrbekova S. A preliminary assessment of the potential environmental and human health impact of unsymmetrical dimethylhydrazine as a result // Chemosphere. – 2007. – Vol. 67. – Р. 1108-1116.
4 Колумбаева С.Ж., Бегимбетова Д.А. Мутагенные эффекты химических загрязнителей окружающей среды. - Алматы: Қазақ университет, 2013. - 196 с.
5 Гераськин С.А., Сарапульцева Е.И., Цаценко Л.В. и др.Биологический контроль окружающей среды. – М.: Издательский центр «Академия», 2010. – 208 с.
6 Lijinsky W. Chemistry and Biology of N-nitroso-compounds. – Cambridge Monographs on Cancer Research, 2011. - 482 p.
7 Guide for the care and use of laboratory animals: Eight Education. - The National Academies Press, 2011. – 246 p
8 Применение метода щелочного гель-электрофореза изолированных клеток для оценки генотоксических свойств природных и синтетических соединений: Методические рекомендации / А.Д. Дурнев [и др.] ; утв. РАМН и РАСН.: М. – 2006.
9 Osipov A., Arkhangelskaya E., Vinokurov A., Smetaninа N., Zhavoronkov A., Klokov D. DNA Comet Giemsa Staining for Conventional Bright-Field Microscopy // Int. J. Mol. Sci. – 2014. - № 15. – Р. 6086-6095
10 Ушакова В.Г., Шпигун О.Н., Старыгин О.И. Особенности химических превращений НДМГ и его поведение в объектах окружающей среды // Ползуновский Вестник. – 2004. - № 4. – С. 177-184.
11 Панин Л.Е., Перова А.Ю. Медико-социальные и экологические проблемы использования ракет на жидком топливе (гептил) // Бюллетень СО РАМН. - 2006. - № 1 (119). - С. 124-131.
12 EPA. Hazard Summary 1,1-Dimethylhydrazine. -2000. - http://www.epa.gov/ttn/uatw/ hlthef/dimethyl.html
13 Kundu K.J., Surh J-Y. Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with antiinXammatory phytochemicals // Mutation Research. – 2005. - Vol. 591. – P. 123–146.
14 Гончарова Р.И., Кужир Т.Д. Молекулярные основы применения антимутагенов в качестве антиканцерогенов // Экологическая генетика. - 2005. - Т. 3. - № 3. – С. 19-32.
15 Kalantari H., Galehdari H., Zaree Z., Gesztelyi R., Varga B., Haines D., Bombicz M., Tosaki A., Juhasz B. Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract // Food and Chemical Toxicology. - 2013. - Vol. 51. - P. 26–32.
16 Timothy O., Idu M., Olorunfemi D.I., Ovuakporie-Uvo O. Cytotoxic and genotoxic properties of leaf extract of Icacina trichantha Oliv. // South African Journal of Botany. - 2014. - Vol. 91. - P. 71–74.
17 Sarac N., Sen B. Antioxidant, mutagenic, antimutagenic activities, and phenoliccompounds of Liquidambar orientalis Mill. var. Orientalis // Industrial Crops and Products. - 2014. - Vol. 53. - P. 60– 64
18 Агабейли Р.А. Антимутагенная активность масла плодов Fagus Orientalis (Fagaceae) // Растительные ресурсы. — 2012. - Т. 48. - № 2. - С. 267-273.
19 Devasagayam T.P., Tilak J.C., Boloor K.K., Sane K.S., Ghaskadbi S.S., Lele R.D. Free Radicals and Antioxidants in Human Health: Current Status and Future Prospects // J Assoc Physicians India. - 2004. - Vol. 52. - P. 794-804.
20 Мамурова А., Мухитдинов Н., Абидкулова К. Фитохимическое изучение трех видов Inula из Казахстана // Вестник Киевского национального университета имени Т.Шевченко. – 2009. - № 25-27. – С. 105-107.
References
1 Database of Chemical Abstracts Service (CAS) - https://www.cas.org/.
2 Kurlyandskiy B.A., Filov V.A. (red.) Obshchaya toksikologiya. - M.: Meditsina, 2002. — 608 p.
3 Carlsen L., Nauryzbaev M., Kenesova O., Batyrbekova S. A preliminary assessment of the potential environmental and human health impact of unsymmetrical dimethylhydrazine as a result // Chemosphere. – 2007. – Vol. 67. – Р. 1108-1116.
4 Kolumbayeva S.Zh., Begimbetova D.A. Mutagennye effekty khimicheskikh zagryazniteley okruzhayushchey sredy. - Almaty: Kazakh university, 2013. - 196 p.
5 Geras'kin S.A., Sarapul'tseva E.I., Tsatsenko L.V. et al. Biologicheskiy kontrol' okruzhayushchey sredy. – M.: Izdatel'skiy tsentr «Akademiya», 2010. – 208 p.
6 Lijinsky W. Chemistry and Biology of N-nitroso-compounds. – Cambridge Monographs on Cancer Research, 2011. - 482 p.
7 Guide for the care and use of laboratory animals: Eight Education. - The National Academies Press, 2011. – 246 p
21 Primenenie metoda shchelochnogo gel'-elektroforeza izolirovannykh kletok dlya otsenki genotoksicheskikh svoystv prirodnykh i sinteticheskikh soedineniy: Metodicheskie rekomendatsii / А.D. Durnev [et al]; utv. RAMN i RASN: М. – 2006.
8 : M. – 2006.
9 Osipov A., Arkhangelskaya E., Vinokurov A., Smetaninа N., Zhavoronkov A., Klokov D. DNA Comet Giemsa Staining for Conventional Bright-Field Microscopy // Int. J. Mol. Sci. – 2014. - № 15. – Р. 6086-6095
10 Ushakova V.G., Shpigun O.N., Starygin O.I. Osobennosti khimicheskikh prevrashcheniy NDMG i ego povedenie v ob"ektakh okruzhayushchey sredy // Polzunovskiy Vestnik. – 2004. - № 4. – P. 177-184.
11 Panin L.E., Perova A.Yu. Mediko-sotsial'nye i ekologicheskie problemy ispol'zovaniya raket na zhidkom toplive (geptil) // Byulleten' SO RAMN. - 2006. - № 1 (119). - P. 124-131..
12 EPA. Hazard Summary 1,1-Dimethylhydrazine. -2000. - http://www.epa.gov/ttn/uatw/ hlthef/dimethyl.html
13 Kundu K.J., Surh J-Y. Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with antiinXammatory phytochemicals // Mutation Research. – 2005. - Vol. 591. – P. 123–146.
14 Goncharova R.I., Kuzhir T.D. Molekulyarnye osnovy primeneniya antimutagenov v kachestve antikantserogenov // Ekologicheskaya genetika. - 2005. - V. 3. - № 3. – P. 19-32.
15 Kalantari H., Galehdari H., Zaree Z., Gesztelyi R., Varga B., Haines D., Bombicz M., Tosaki A., Juhasz B. Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract // Food and Chemical Toxicology. - 2013. - Vol. 51. - P. 26–32.
16 Timothy O., Idu M., Olorunfemi D.I., Ovuakporie-Uvo O. Cytotoxic and genotoxic properties of leaf extract of Icacina trichantha Oliv. // South African Journal of Botany. - 2014. - Vol. 91. - P. 71–74.
17 Sarac N., Sen B. Antioxidant, mutagenic, antimutagenic activities, and phenoliccompounds of Liquidambar orientalis Mill. var. Orientalis // Industrial Crops and Products. - 2014. - Vol. 53. - P. 60– 64
18 Agabeyli R.A. Antimutagennaya aktivnost' masla plodov Fagus Orientalis (Fagaceae) // Rastitel'nye resursy. — 2012. - Vol. 48. - № 2. - P. 267-273.
19 Devasagayam T.P., Tilak J.C., Boloor K.K., Sane K.S., Ghaskadbi S.S., Lele R.D. Free Radicals and Antioxidants in Human Health: Current Status and Future Prospects // J Assoc Physicians India. - 2004. - Vol. 52. - P. 794-804.
20 Mamurova A., Mukhitdinov N., Abidkulova K. Fitokhimicheskoe izuchenie trekh vidov Inula iz Kazakhstana // Vestnik Kievskogo natsional'nogo universiteta imeni T.Shevchenko. – 2009. - № 25-27. – P. 105-107.
1 База данных Chemical Abstracts Service (CAS) - https://www.cas.org/.
2 Курляндский Б.А., Филов В.А. (ред.) Общая токсикология. - М.: Медицина, 2002. — 608 с.
3 Carlsen L., Nauryzbaev M., Kenesova O., Batyrbekova S. A preliminary assessment of the potential environmental and human health impact of unsymmetrical dimethylhydrazine as a result // Chemosphere. – 2007. – Vol. 67. – Р. 1108-1116.
4 Колумбаева С.Ж., Бегимбетова Д.А. Мутагенные эффекты химических загрязнителей окружающей среды. - Алматы: Қазақ университет, 2013. - 196 с.
5 Гераськин С.А., Сарапульцева Е.И., Цаценко Л.В. и др.Биологический контроль окружающей среды. – М.: Издательский центр «Академия», 2010. – 208 с.
6 Lijinsky W. Chemistry and Biology of N-nitroso-compounds. – Cambridge Monographs on Cancer Research, 2011. - 482 p.
7 Guide for the care and use of laboratory animals: Eight Education. - The National Academies Press, 2011. – 246 p
8 Применение метода щелочного гель-электрофореза изолированных клеток для оценки генотоксических свойств природных и синтетических соединений: Методические рекомендации / А.Д. Дурнев [и др.] ; утв. РАМН и РАСН.: М. – 2006.
9 Osipov A., Arkhangelskaya E., Vinokurov A., Smetaninа N., Zhavoronkov A., Klokov D. DNA Comet Giemsa Staining for Conventional Bright-Field Microscopy // Int. J. Mol. Sci. – 2014. - № 15. – Р. 6086-6095
10 Ушакова В.Г., Шпигун О.Н., Старыгин О.И. Особенности химических превращений НДМГ и его поведение в объектах окружающей среды // Ползуновский Вестник. – 2004. - № 4. – С. 177-184.
11 Панин Л.Е., Перова А.Ю. Медико-социальные и экологические проблемы использования ракет на жидком топливе (гептил) // Бюллетень СО РАМН. - 2006. - № 1 (119). - С. 124-131.
12 EPA. Hazard Summary 1,1-Dimethylhydrazine. -2000. - http://www.epa.gov/ttn/uatw/ hlthef/dimethyl.html
13 Kundu K.J., Surh J-Y. Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with antiinXammatory phytochemicals // Mutation Research. – 2005. - Vol. 591. – P. 123–146.
14 Гончарова Р.И., Кужир Т.Д. Молекулярные основы применения антимутагенов в качестве антиканцерогенов // Экологическая генетика. - 2005. - Т. 3. - № 3. – С. 19-32.
15 Kalantari H., Galehdari H., Zaree Z., Gesztelyi R., Varga B., Haines D., Bombicz M., Tosaki A., Juhasz B. Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract // Food and Chemical Toxicology. - 2013. - Vol. 51. - P. 26–32.
16 Timothy O., Idu M., Olorunfemi D.I., Ovuakporie-Uvo O. Cytotoxic and genotoxic properties of leaf extract of Icacina trichantha Oliv. // South African Journal of Botany. - 2014. - Vol. 91. - P. 71–74.
17 Sarac N., Sen B. Antioxidant, mutagenic, antimutagenic activities, and phenoliccompounds of Liquidambar orientalis Mill. var. Orientalis // Industrial Crops and Products. - 2014. - Vol. 53. - P. 60– 64
18 Агабейли Р.А. Антимутагенная активность масла плодов Fagus Orientalis (Fagaceae) // Растительные ресурсы. — 2012. - Т. 48. - № 2. - С. 267-273.
19 Devasagayam T.P., Tilak J.C., Boloor K.K., Sane K.S., Ghaskadbi S.S., Lele R.D. Free Radicals and Antioxidants in Human Health: Current Status and Future Prospects // J Assoc Physicians India. - 2004. - Vol. 52. - P. 794-804.
20 Мамурова А., Мухитдинов Н., Абидкулова К. Фитохимическое изучение трех видов Inula из Казахстана // Вестник Киевского национального университета имени Т.Шевченко. – 2009. - № 25-27. – С. 105-107.
References
1 Database of Chemical Abstracts Service (CAS) - https://www.cas.org/.
2 Kurlyandskiy B.A., Filov V.A. (red.) Obshchaya toksikologiya. - M.: Meditsina, 2002. — 608 p.
3 Carlsen L., Nauryzbaev M., Kenesova O., Batyrbekova S. A preliminary assessment of the potential environmental and human health impact of unsymmetrical dimethylhydrazine as a result // Chemosphere. – 2007. – Vol. 67. – Р. 1108-1116.
4 Kolumbayeva S.Zh., Begimbetova D.A. Mutagennye effekty khimicheskikh zagryazniteley okruzhayushchey sredy. - Almaty: Kazakh university, 2013. - 196 p.
5 Geras'kin S.A., Sarapul'tseva E.I., Tsatsenko L.V. et al. Biologicheskiy kontrol' okruzhayushchey sredy. – M.: Izdatel'skiy tsentr «Akademiya», 2010. – 208 p.
6 Lijinsky W. Chemistry and Biology of N-nitroso-compounds. – Cambridge Monographs on Cancer Research, 2011. - 482 p.
7 Guide for the care and use of laboratory animals: Eight Education. - The National Academies Press, 2011. – 246 p
21 Primenenie metoda shchelochnogo gel'-elektroforeza izolirovannykh kletok dlya otsenki genotoksicheskikh svoystv prirodnykh i sinteticheskikh soedineniy: Metodicheskie rekomendatsii / А.D. Durnev [et al]; utv. RAMN i RASN: М. – 2006.
8 : M. – 2006.
9 Osipov A., Arkhangelskaya E., Vinokurov A., Smetaninа N., Zhavoronkov A., Klokov D. DNA Comet Giemsa Staining for Conventional Bright-Field Microscopy // Int. J. Mol. Sci. – 2014. - № 15. – Р. 6086-6095
10 Ushakova V.G., Shpigun O.N., Starygin O.I. Osobennosti khimicheskikh prevrashcheniy NDMG i ego povedenie v ob"ektakh okruzhayushchey sredy // Polzunovskiy Vestnik. – 2004. - № 4. – P. 177-184.
11 Panin L.E., Perova A.Yu. Mediko-sotsial'nye i ekologicheskie problemy ispol'zovaniya raket na zhidkom toplive (geptil) // Byulleten' SO RAMN. - 2006. - № 1 (119). - P. 124-131..
12 EPA. Hazard Summary 1,1-Dimethylhydrazine. -2000. - http://www.epa.gov/ttn/uatw/ hlthef/dimethyl.html
13 Kundu K.J., Surh J-Y. Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with antiinXammatory phytochemicals // Mutation Research. – 2005. - Vol. 591. – P. 123–146.
14 Goncharova R.I., Kuzhir T.D. Molekulyarnye osnovy primeneniya antimutagenov v kachestve antikantserogenov // Ekologicheskaya genetika. - 2005. - V. 3. - № 3. – P. 19-32.
15 Kalantari H., Galehdari H., Zaree Z., Gesztelyi R., Varga B., Haines D., Bombicz M., Tosaki A., Juhasz B. Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract // Food and Chemical Toxicology. - 2013. - Vol. 51. - P. 26–32.
16 Timothy O., Idu M., Olorunfemi D.I., Ovuakporie-Uvo O. Cytotoxic and genotoxic properties of leaf extract of Icacina trichantha Oliv. // South African Journal of Botany. - 2014. - Vol. 91. - P. 71–74.
17 Sarac N., Sen B. Antioxidant, mutagenic, antimutagenic activities, and phenoliccompounds of Liquidambar orientalis Mill. var. Orientalis // Industrial Crops and Products. - 2014. - Vol. 53. - P. 60– 64
18 Agabeyli R.A. Antimutagennaya aktivnost' masla plodov Fagus Orientalis (Fagaceae) // Rastitel'nye resursy. — 2012. - Vol. 48. - № 2. - P. 267-273.
19 Devasagayam T.P., Tilak J.C., Boloor K.K., Sane K.S., Ghaskadbi S.S., Lele R.D. Free Radicals and Antioxidants in Human Health: Current Status and Future Prospects // J Assoc Physicians India. - 2004. - Vol. 52. - P. 794-804.
20 Mamurova A., Mukhitdinov N., Abidkulova K. Fitokhimicheskoe izuchenie trekh vidov Inula iz Kazakhstana // Vestnik Kievskogo natsional'nogo universiteta imeni T.Shevchenko. – 2009. - № 25-27. – P. 105-107.
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Kolumbayeva, S. Z., Lovinskaya, A. V., Shynbergenova, N. S., Rakhimzhanova, A. A., Iliasova, A. I., Begimbetova, D. A., & Voronova, N. V. (2016). ANTIGENOTOXIC EFFECT FROM HERBAL TEA OF ELECAMPANE (INULA HELENIUM L.) ROOTS AND RHIZOMES. Experimental Biology, 65(3), 134–141. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/1109
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МOLECULAR BIOLOGY AND GENETICS