GENES ASSOCIATED WITH THE DEVELOPMENT OF ISCHEMIC HEART DISEASE
Keywords:
ischemic heart disease, gene, microRNA, mRNA, diagnostics.Abstract
The search of the genes-candidates associated with the development of ischemic heart disease is conducted. A database of genes associated with the development of ischemic heart disease is created and the functions of these genes analyzed in a comparative aspect. It has been shown that many of the genes involved in the development of ischemic heart disease also associated with the development of other cardiovascular diseases: myocardial infarction, hypertension, atherosclerosis, metabolic syndrome. These genes participating in different social meaningful diseases is analyzed. A database of genes associated with the development of ischemic heart disease is the basis for the identification of genes which expression is dependent on the action of microRNAs. The features of the resulting database of genes in the development of ischemic heart disease early diagnostics methods, using molecular genetic markers are discussed.References
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4. Hamrefors V. Common genetic risk factors for coronary artery disease: new opportunities for prevention? // Clinical Physiology and Functional Imaging. – 2015. - V. 17. - P. 128-141.
5. Cole C.B., Nikpay M., Stewart A.F., McPherson R. Increased genetic risk for obesity in premature coronary artery disease // European Journal of Human Genetics. – 2015. - V. 29. - P. 53-69.
6. Yamada Y., Matsui K., Takeuchi I., Fujimaki T. Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study // Biomedical Report. – 2015. - V. 3, N. 3. – P. 413-419.
7. Ozaki K., Tanaka T. Molecular genetics of coronary artery disease // Journal of Human Genetics. – 2015. - V. 2. - P. 250-258.
8. Neelankavil J., Rau C.D., Wang Y. The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets // Journal of Cardiothoracic and Vascular Anesthesia. – 2015. - V. 29, N. 5. – P. 1328-1332.
9. Hernesniemi J.A., Lyytikäinen L.P., Oksala N., et al. Predicting sudden cardiac death using common genetic risk variants for coronary artery disease // European Heart Journal. - 2015. - V. 36, N. 26. – P. 1669-1675.
10. Cheng Y., An B., Jiang M., Xin Y., Xuan S. Association of Tumor Necrosis Factor-alpha Polymorphisms and Risk of Coronary Artery Disease in Patients With Non-alcoholic Fatty Liver Disease // Hepatitis Monthly. – 2015. - V. 15, N. 3. – P. 68-81.
11. Liao B., Cheng K., Dong S., Liu H., Xu Z. Effect of apolipoprotein A1 genetic polymorphisms on lipid profiles and the risk of coronary artery disease // Diagnostics of Pathologies. – 2015. - V. 16, N. 10. – P. 102.
12. Cui F., Li K., Li Y., Zhang X., An C. Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population // Lipids Health Diseases. – 2014. - V. 8, N. 13. – P. 170.
13. Arslan S., Korkmaz Ö., Özbilüm N., Berkan Ö. Association between NF-κBI and NF-κBIA polymorphisms and coronary artery disease // Biomedical Report. – 2015. - V. 3, N. 5. – P. 736-740.
14. Ahmadi Z., Senemar S., Toosi S., Radmanesh S. The Association of Lipoprotein Lipase Genes, HindIII and S447X Polymorphisms With Coronary Artery Disease in Shiraz City // Jounal of Cardiovascular and Thoracic Research. – 2015. - V. 7, N. 2. – P. 63-67.
15. Xiao J., Luo X., Lin H., Zhang Y., Lu Y., Wang N., Zhang Y., Yang B., Wang Z. MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts // Journal of Biological Chemistry. - 2011. - V. 286, N. 32. - P. 56-86.
16. Shan H., Zhang Y., Cai B., Chen X., Fan Y., Yang L., Chen X., Liang H., Zhang Y., Song X., Xu C., Lu Y., Yang B., Du Z. Upregulation of microRNA-1 and microRNA-133 contributes to arsenic-induced cardiac electrical remodeling // International Journal of Cardiology. - 2013. - V. 167, N. 6. - P. 2798-2805.
17. Luo X., Lin H., Pan Z., Xiao J., Zhang Y., Lu Y., Yang B., Wang Z. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart // Journal of Biological Chemistry. - 2008. - V. 283, N. 29. - P. 20045-20052.
18. Wang N., Zhou Z., Liao X., Zhang T. Role of microRNAs in cardiac hypertrophy and heart failure // International Union of Biochemistry and Molecular Biology Life. - 2009. - V. 61, N. 6. - P. 566-571.
19. Ye Y., Perez-Polo J.R., Qian J., Birnbaum Y. The role of microRNA in modulating myocardial ischemia-reperfusion injury // Physiological Genomics. - 2011. - V. 43, N. 10. - P. 534-542.
20. Ono K., Kuwabara Y., Han J. MicroRNAs and cardiovascular diseases // Federation of European Biochemical Societies Journal. - 2011. - V. 278, N. 10. - P. 1619-1633.
21. Papoutsidakis N., Deftereos S., Kaoukis A., Bouras G., Giannopoulos G., Theodorakis A., Angelidis C., Hatzis G., Stefanadis C. MicroRNAs and the heart: small things do matter // Current Topics in Medicinal Chemistry. - 2013. - V. 13, N. 2. - P. 216-230.
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