СВОЙСТВА ИНТРОННЫХ miRNA ЧЕЛОВЕКА И ОСОБЕННОСТИ ИХ ВЗАИМОДЕЙСТВИЯ С mRNA
Keywords:
51 genes coding intronic miRNAs,Abstract
Sites of interaction 686 intronic miRNAs with mRNAs of 51 genes coding intronic miRNAs are established. Peculiarities of interaction of observed miRNAs with mRNAs of each gene in 5'UTR, CDS and 3'UTR are revealed. Appreciable heterogeneity of functional sites of mRNAs on number of sites of linkage miRNAs with mRNAs and on density of locating of these sites is established. Intronic miRNAs differenst by selectivity to mRNAs of certains genes are revealed.References
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2 Rodriguez A., et al. Identification of mammalian microRNA host genes and transcription units // Genome Res.- 2004. - V. 14. - P. 1902-191
3 Lutter D., Marr C., Krumsiek J., Lang E.W., Theis F.J. Intronic microRNAs support their host genes bymediating synergistic and antagonistic regulatory effects // BMC Genomics. - 2010. - V. 11:224. - doi:10.1186/1471-2164-11-224.
4 Ying S.-Y., Lin S.-L. Current Perspectives In Intronic microRNAs (miRNAs) // Journal of Biomedical Science. -2006. - V.13, № 2. - С. 23-30.
5 Lee E. J., Gusev Y., Jiang J. Expression profiling identifies microRNA signature in pancreatic cancer. // Int J
Cancer. - 2006. - V. 45, № 3. - P. 36-40.
6 Bloomston M., Frankel W.L., Petrocca F. Profils d’expression du microARN pour différencierl’adénocarcinome pancréatique d’un pancréas normal et d’une pancréatite chronique // JAMA. - 2007. - V. 297. - №
17. - P. 190.
7 Iorio M.V., Ferracin M., Liu C.G. MicroRNA gene expression deregulation in // Cancer Res. - 2005. - V. 65. -P. 7065-7070.
8 Ryan B.M., Robles A.I., Harris C.C. Genetic variation in microRNA networks: the implications for cancerresearch // Nat. Rev. Cancer. - 2010. - V. 10 (6). - P. 389-402.
9 Emma V. B., et al. microRNA evaluation of unknown primary lesions in the head and neck // MolecularCancer. - 2009. - V. 8. - № 127. - P. 1-7.
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