Colon cancer stem cells self regulation.
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Keywords:
colon cancer, cancer stem cells, autocrine inductors, cytokines, growth factors,Abstract
Colon cancer high death rate and low percentage of recovery depend on tumor initiating cancer stem cells (CSCs). CSCs have ability such as survival in stress condition, absence of sensitivity to apoptose. These properties CSCs can regulate by autocrine way. In our work it was created data base of colon CSCs autocrine inductors. Understanding of CSCs protection mechanisms help to develop effective elimination methods of these cells.References
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4 Cunningham D., Atkin W., Lenz H.J. et al. Colorectal cancer // The Lancet. – 2010. – Vol. 375, № 9719. – Р. 1030-1047.
5 Dean M., Fojo T., Bates S. Tumour stem cells and drug resistance // Nat Rev Cancer. – 2005. – Vol. 5, № 4. – P. 275–284.
6 Clarke M.F., Dick J.E., Dirks P.B. et al. Cancer stem cells–perspectives on current status and future directions: AACR Workshop
on cancer stem cells // Cancer Res. – 2006. – Vol. 66. – P. 9339–44.
7 A.M. Krasinskas. EGFR Signaling in Colorectal Carcinoma // Pathology Research International. – 2011. – Vol. 2011. – ID 932932.
8 Lewis A.M.Varghese S., Xu H.et al. Interleukin-1 cancer progression : the emerging role of interleukin-1 eceptorantagonist as a novel therapeutic agent in cancer treatment // Journal of Translational Medicine. – 2006. – Vol. 4, № 48. – doi:10.1186/1479-5876-4-48.
9 Todaro M., Alea M.P., Stefano A.B.D. et al. Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production
of Interleukin-4 // Cell Stem Cell. – 2007. – Vol. 1. – P. 389–402.
10 Zenewicz L.A., Flavell R.A. IL-22 and inflammation: leukin’ hrough a glass onion // Eur J Immunol. – 2008. – Vol. 38. – P. 3265-3268.
11 Yano T., Ito K., Fukamachi H. et al.The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming
growth factor β-induced apoptosis // Mol Cell Biol. – 2006. – Vol. 26. – P. 4474–88.
12 Li Q.L., Ito K., Sakakura C. et al. Causal relationship between the loss of RUNX3 expression and gastric cancer // Cell. – 2002. – Vol. 109. – P. 113–24.
13 Ito K., Lim A.C., Salto-Tellez M. et al. RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis // Cancer Cell. –2008. – Vol. 14. – P. 226–37.
14 Spaderna S., Schmalhofer O., Wahlbuhl M. et al. The ranscriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer // Cancer Res. – 2008. – Vol. 68. – P. 537–544.
15 Waldner M.J., Foersch S., Neurath M.F. Interleukin-6 – A Key Regulator of Colorectal Cancer Development // Int. J. Biol. Sci.–2012. – Vol. 8. – P.1248-1253.
16 Wang R.J., Peng R.Y., Fu K.F. et al. Effect of recombinant human interleukin-11 on expressions of interleukin-11 receptor alphachain and glycoprotein 130 in intestinal epithelium cell line-6 after neutron irradiation // World J Gastroenterol. – 2006. – Vol. 12. – P. 3055-3059.
17 Bates R.C., DeLeo M.J., Mercurio A.M. The epithelial–mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis // Exp. Cell Res. – 2004. – Vol. 299, № 2. – P. 315–324.
18 Hwang W.L., Yang M.H., Tsai M.L. et al. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity
of human colorectal carcinoma cells // Gastroenterology. – 2011. – Vol. 141, №1. – P. 279–291.
19 Chang C.-J., Chien Y., Lu K.-H. et al. Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells //Biochemical and Biophysical Research Communications. – 2011. – Vol. 415, № 2. – P. 245–251.
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Issabekova, A. S., & Ogay, V. B. (2015). Colon cancer stem cells self regulation. Experimental Biology, 60(1), 102–105. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/67
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Biomedicine
