Паракринные регуляторы раковых стволовых клеток толстой кишки. Тоқ ішектің бағаналы ісік жасушаларының паракринды реттеушілері.
Ключевые слова:
раковые стволовые клетки, микроокружение, бағаналы ісік жасушалары, микроайнала, қоздырушалар,Аннотация
Раковые стволовые клетки основная причина возобновления болезни после лечения. Для эффективной борьбы с этими клетками необходимо понимание механизмов выживание этих клеток и их стимуляторов. В данной работе оценено влияние микроокружение опухоли на рост и поддержание опухоли. Основными модуляторами раковых стволовых клеток являются опухоль ассоциированные миофибробласты и макрофаги, а также Th17 клетки. Бағаналы ісік жасушалары аурудың емдеуден кейін қайталануының негізгі себепшісілері. Бұл клеткалармен нәтижелі күресу үшін бұл клеткалардың тірі қалу механизмдерін және оларды қоздыратын заттарды түсіну қажет. Бұл жұмыста ісік микроайналасының ісіктің өсуі мен өркендеуіне қосатын үлесі бағаланған. Бағаналы ісік клеткаларының негізгі реттеушілері ісікпен байланысқан миофибробластар мен макрофагтар және Th17 клеткаларыБиблиографические ссылки
1 Merlos-Suárez A., Barriga F.M., Jung P. et al. The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse // Cell Stem Cell. – 2011. – Vol. 8, № 5. – P. 511-524.
2 Croker A.K., Allan A.L. Cancer stem cells: implications for the progression and treatment of metastatic disease // J. Cell. Mol. Med. – 2008. – Vol. 12, №2. – P. 374-390.
3 Clevers H. Wnt/beta-catenin signaling in development and disease // Cell. – 2006. – Vol. 127. – P. 469–80.
4 Pinchuk I.V., Mifflin R. C., Saada J. I. et al. Intestinal Mesenchymal Cells // Curr Gastroenterol Rep. – 2010. – Vol. 12, № 5. – P. 310–318.
5 Vermeulen L., De Sousa E., Melo F. et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment // Nat Cell Biol. – 2010. – Vol. 12. – P. 468–76.
6 Shinagawa K., Kitadai Y., Tanaka M. et al Mesenchymal stem cells enhance growth and metastasis of colon cancer // Int. J. Cancer. – 2010. – Vol. 127. – P. 2323–2333.
7 Postovit L.M., Margaryan N.V., Seftor E.et al. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells // Proc Natl Acad Sci U S A. – 2008. – Vol. 105, № 11. – Р.4329-34.
8 Lin W.W., Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer // J Clin Invest. – 2007. – Vol.
117. – P. 1175–1183.
9 Zheng Y., Valdez P.A., Danilenko D.M. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial
pathogens // Nat. Med. – 2008. – Vol. 14. – P. 282–289.
10 Wu S., Rhee K.J., Albesiano E. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses // Nat Med. – 2009. – Vol. 15. – P. 1016-1022.
11 Schwaab T., Weiss J.E., Schned A.R. et al. Dendritic cell nfiltration in colon cancer // J Immunother. – 2001. – Vol. 24, № 2. – P. 130-7.
12 Rigo A., Gottardi M., Zamò A.Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12 // Mol Cancer. – 2010. – Vol. 9, № 273.
13 Kaler P., Augenlicht L., Klampfer L. Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3 // Oncogene. – 2009. – Vol. 28. – P. 3892–3902.
14 Hao N.-B., Lu M.-H, Fan Y.-H. et al. Macrophages in Tumor Microenvironments and the Progression of Tumors / Clin Dev Immunol. – 2012. – Vol. 2012, № 948098. – doi: 10.1155/2012/948098.
15 Onnis В., Fer N., Rapisarda A. et al Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells // J Clin Invest. – 2013. – Vol. 123, № 4. – Р. 1615–1629. – doi:10.1172/JCI59623.
16 Suzuki H., Ogawa H., Miura K. et al. IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma //Oncology Letters. – 2012. – Vol. 4, № 2. – P. 199-204.
17 Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes // Cell. – 2003. –Vol. 114. – P. 181–90.
2 Croker A.K., Allan A.L. Cancer stem cells: implications for the progression and treatment of metastatic disease // J. Cell. Mol. Med. – 2008. – Vol. 12, №2. – P. 374-390.
3 Clevers H. Wnt/beta-catenin signaling in development and disease // Cell. – 2006. – Vol. 127. – P. 469–80.
4 Pinchuk I.V., Mifflin R. C., Saada J. I. et al. Intestinal Mesenchymal Cells // Curr Gastroenterol Rep. – 2010. – Vol. 12, № 5. – P. 310–318.
5 Vermeulen L., De Sousa E., Melo F. et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment // Nat Cell Biol. – 2010. – Vol. 12. – P. 468–76.
6 Shinagawa K., Kitadai Y., Tanaka M. et al Mesenchymal stem cells enhance growth and metastasis of colon cancer // Int. J. Cancer. – 2010. – Vol. 127. – P. 2323–2333.
7 Postovit L.M., Margaryan N.V., Seftor E.et al. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells // Proc Natl Acad Sci U S A. – 2008. – Vol. 105, № 11. – Р.4329-34.
8 Lin W.W., Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer // J Clin Invest. – 2007. – Vol.
117. – P. 1175–1183.
9 Zheng Y., Valdez P.A., Danilenko D.M. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial
pathogens // Nat. Med. – 2008. – Vol. 14. – P. 282–289.
10 Wu S., Rhee K.J., Albesiano E. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses // Nat Med. – 2009. – Vol. 15. – P. 1016-1022.
11 Schwaab T., Weiss J.E., Schned A.R. et al. Dendritic cell nfiltration in colon cancer // J Immunother. – 2001. – Vol. 24, № 2. – P. 130-7.
12 Rigo A., Gottardi M., Zamò A.Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12 // Mol Cancer. – 2010. – Vol. 9, № 273.
13 Kaler P., Augenlicht L., Klampfer L. Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3 // Oncogene. – 2009. – Vol. 28. – P. 3892–3902.
14 Hao N.-B., Lu M.-H, Fan Y.-H. et al. Macrophages in Tumor Microenvironments and the Progression of Tumors / Clin Dev Immunol. – 2012. – Vol. 2012, № 948098. – doi: 10.1155/2012/948098.
15 Onnis В., Fer N., Rapisarda A. et al Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells // J Clin Invest. – 2013. – Vol. 123, № 4. – Р. 1615–1629. – doi:10.1172/JCI59623.
16 Suzuki H., Ogawa H., Miura K. et al. IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma //Oncology Letters. – 2012. – Vol. 4, № 2. – P. 199-204.
17 Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes // Cell. – 2003. –Vol. 114. – P. 181–90.
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