Саморегуляция раковых стволовых клеток толстой кишки. Тоқ ішек бағаналы ісік жасушаларының өздігінен реттелуі.
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Ключевые слова:
рак толстой кишки, раковые стволовые клетки, тоқ ішек ісігі, бағаналы ісік жасушалары, аутокринды реттеушілер, аутокринные стимуляторы, цитокины, росто-вые факторы,Аннотация
Высокая смертность от рака толстой кишки и низкий процент полного выздоровления от рака связаны с существованием опухоль инициирующих раковых стволовых клеток (РСК). РСК обладают такими свойствами как выживаемость, отсутствие чувствительности к апоптозу. Эти свойства РСК способны регулировать аутокринным путем. В нашей работе была создана база данных по аутокринным стимуляторам РСК толстой кишки. Понимание защитных механизмов РСК поможет разработать эффективные методы элиминации этих клеток. Тоқ ішек ісігінен өлім дәрежесінің жоғары болуы және ісіктен толық айығу үлесінің төмен болуы бағаналы ісік жасушаларымен (БІЖ) байланысты екені белгілі. БІЖ өміршеңдік, апоптозға сезімталдықтық болмауы сияқты қасиеттері бар. Бұл қасиеттерді БІЖ аутокринды жолмен реттей алады. Біздің жұмыста тоқ ішек БІЖ аутокрин- ды реттеушілерінің мәліметтер базасы жасалды. БІЖ қорғаныс механизмдерін түсіну бұл жасушаларды жою әдістерін шығаруға көмектеседі.Библиографические ссылки
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9 Todaro M., Alea M.P., Stefano A.B.D. et al. Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production
of Interleukin-4 // Cell Stem Cell. – 2007. – Vol. 1. – P. 389–402.
10 Zenewicz L.A., Flavell R.A. IL-22 and inflammation: leukin’ hrough a glass onion // Eur J Immunol. – 2008. – Vol. 38. – P. 3265-3268.
11 Yano T., Ito K., Fukamachi H. et al.The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming
growth factor β-induced apoptosis // Mol Cell Biol. – 2006. – Vol. 26. – P. 4474–88.
12 Li Q.L., Ito K., Sakakura C. et al. Causal relationship between the loss of RUNX3 expression and gastric cancer // Cell. – 2002. – Vol. 109. – P. 113–24.
13 Ito K., Lim A.C., Salto-Tellez M. et al. RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis // Cancer Cell. –2008. – Vol. 14. – P. 226–37.
14 Spaderna S., Schmalhofer O., Wahlbuhl M. et al. The ranscriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer // Cancer Res. – 2008. – Vol. 68. – P. 537–544.
15 Waldner M.J., Foersch S., Neurath M.F. Interleukin-6 – A Key Regulator of Colorectal Cancer Development // Int. J. Biol. Sci.–2012. – Vol. 8. – P.1248-1253.
16 Wang R.J., Peng R.Y., Fu K.F. et al. Effect of recombinant human interleukin-11 on expressions of interleukin-11 receptor alphachain and glycoprotein 130 in intestinal epithelium cell line-6 after neutron irradiation // World J Gastroenterol. – 2006. – Vol. 12. – P. 3055-3059.
17 Bates R.C., DeLeo M.J., Mercurio A.M. The epithelial–mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis // Exp. Cell Res. – 2004. – Vol. 299, № 2. – P. 315–324.
18 Hwang W.L., Yang M.H., Tsai M.L. et al. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity
of human colorectal carcinoma cells // Gastroenterology. – 2011. – Vol. 141, №1. – P. 279–291.
19 Chang C.-J., Chien Y., Lu K.-H. et al. Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells //Biochemical and Biophysical Research Communications. – 2011. – Vol. 415, № 2. – P. 245–251.
2 Ferlay J., Shin H.R., Bray F.et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 // Int J Cancer. – 2010. – Vol. 127, № 12. – P. 2893-2917.
3 Bray F., Ren J.S., Masuyer E. et al. Global estimates of cancer prevalence for 27 sites in the adult population in 2008 // Int J Cancer. – 2012. – doi: 10.1002/ijc.27711.
4 Cunningham D., Atkin W., Lenz H.J. et al. Colorectal cancer // The Lancet. – 2010. – Vol. 375, № 9719. – Р. 1030-1047.
5 Dean M., Fojo T., Bates S. Tumour stem cells and drug resistance // Nat Rev Cancer. – 2005. – Vol. 5, № 4. – P. 275–284.
6 Clarke M.F., Dick J.E., Dirks P.B. et al. Cancer stem cells–perspectives on current status and future directions: AACR Workshop
on cancer stem cells // Cancer Res. – 2006. – Vol. 66. – P. 9339–44.
7 A.M. Krasinskas. EGFR Signaling in Colorectal Carcinoma // Pathology Research International. – 2011. – Vol. 2011. – ID 932932.
8 Lewis A.M.Varghese S., Xu H.et al. Interleukin-1 cancer progression : the emerging role of interleukin-1 eceptorantagonist as a novel therapeutic agent in cancer treatment // Journal of Translational Medicine. – 2006. – Vol. 4, № 48. – doi:10.1186/1479-5876-4-48.
9 Todaro M., Alea M.P., Stefano A.B.D. et al. Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production
of Interleukin-4 // Cell Stem Cell. – 2007. – Vol. 1. – P. 389–402.
10 Zenewicz L.A., Flavell R.A. IL-22 and inflammation: leukin’ hrough a glass onion // Eur J Immunol. – 2008. – Vol. 38. – P. 3265-3268.
11 Yano T., Ito K., Fukamachi H. et al.The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming
growth factor β-induced apoptosis // Mol Cell Biol. – 2006. – Vol. 26. – P. 4474–88.
12 Li Q.L., Ito K., Sakakura C. et al. Causal relationship between the loss of RUNX3 expression and gastric cancer // Cell. – 2002. – Vol. 109. – P. 113–24.
13 Ito K., Lim A.C., Salto-Tellez M. et al. RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis // Cancer Cell. –2008. – Vol. 14. – P. 226–37.
14 Spaderna S., Schmalhofer O., Wahlbuhl M. et al. The ranscriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer // Cancer Res. – 2008. – Vol. 68. – P. 537–544.
15 Waldner M.J., Foersch S., Neurath M.F. Interleukin-6 – A Key Regulator of Colorectal Cancer Development // Int. J. Biol. Sci.–2012. – Vol. 8. – P.1248-1253.
16 Wang R.J., Peng R.Y., Fu K.F. et al. Effect of recombinant human interleukin-11 on expressions of interleukin-11 receptor alphachain and glycoprotein 130 in intestinal epithelium cell line-6 after neutron irradiation // World J Gastroenterol. – 2006. – Vol. 12. – P. 3055-3059.
17 Bates R.C., DeLeo M.J., Mercurio A.M. The epithelial–mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis // Exp. Cell Res. – 2004. – Vol. 299, № 2. – P. 315–324.
18 Hwang W.L., Yang M.H., Tsai M.L. et al. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity
of human colorectal carcinoma cells // Gastroenterology. – 2011. – Vol. 141, №1. – P. 279–291.
19 Chang C.-J., Chien Y., Lu K.-H. et al. Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells //Biochemical and Biophysical Research Communications. – 2011. – Vol. 415, № 2. – P. 245–251.
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Issabekova, A. S., & Ogay, V. B. (2015). Саморегуляция раковых стволовых клеток толстой кишки. Тоқ ішек бағаналы ісік жасушаларының өздігінен реттелуі. Вестник КазНУ. Серия биологическая, 60(1), 102–105. извлечено от https://bb.kaznu.kz/index.php/biology/article/view/67
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