Association of MLH1-93G> A polymorphism with the risk of colorectal cancer in Kazakhstan population
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Keywords:
colorectal cancer, MLH1-93G>A polymorphism, Kazakhstan population, PCR-RFLP, казахстанская популяция, ПЦР-ПДРФ,Abstract
The results of molecular and epidemiological studies to determine the association of MLH1-93G>A (rs1800734) polymorphism with the development of CRC among Almaty residents are presented here. Genotyping of this polymorphism was performed in 247 patients with colorectal cancer and 244 healthy controls. The statistical analysis showed reliable association of -93GG genotype with the development of colorectal cancer in Kazakhstan citizens.References
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375 (9719). – P. 1030-1047.
2 Merika E., Saif M.W., Katz A., Syrigos K., Morse M., Review. Colon cancer vaccines: an update // In vivo (Athens, Greece). –2010. – V. 24 (5). – P. 607-628.
3 Malekzadeh R., Bishehsari F., Mahdavinia M., Ansari R., Epidemiology and molecular genetics of colorectal cancer in iran // A
review. Arch Iran Med, – 2009. – V. 12. – P. 161–169.
4 Jean M., Pelletier J., Hilpert M., Belzile F., Kunze R., Isolation and characterization of AtMLH1, a MutL homologue from Arabidopsis
thaliana // Mol Gen Genet. – 1999. V. 262. -P. 633–642.
5 Jiricny J., The multifaceted mismatch-repair system // Nat. Rev. Mol. Cell Biol. – 2006. – V. 7. – P. 335–346.
6 Hardman R.A., Afshari C.A., Barrett J.C., Involvement of ammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress // Cancer Res. – 2001. – V. 61. – P. 1392–1397.
7 Perera S., Mrkonjic M., Rawson J.B., Bapat B., Functional effects of the MLH1 −93G>A polymorphism on MLH1/EPM2AIP1 promoter activity // Oncol. Rep. – 2011. – V. 25. – P. 809–815.
8 Allan J. M., Shorto J., Adlard J. et al., MLH1 -93G.A promoter polymorphism and risk of mismatch repair deficient colorectal cancer // Int. J. Cancer. – 2008. V. 123. P. 2456–2459.
9 Raptis S. Mrkonjic M., Green R.C., et al., MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer // J Natl Cancer Inst. -2007. – V. 99, – P. 463-474.
10 Muniz-Mendoza R., Ayala-Madrigal M.L., Partida-Perez M., et al., MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer // Genet Mol Res. -2012. – V. 11. – P. 2315-2320.
11 Mohd Nizam Z., Abdul Aziz A. A., Gurjeet K., et al., Contribution of the MLH1 -93G>A Promoter Polymorphism in Modulating Susceptibility Risk in Malaysian Colorectal Cancer Patients // Asian Pacific J Cancer Prev. – 2013. – V. 14 (2), – P. 619-624.
12 Park S. H., Lee G. Y., Jeon H. S. et al., -93G-.A polymorphism of hMLH1 and risk of primary lung cancer // Int. J. Cancer. –2004. – V. 112. – P. 678–682.
13 Shih C. M., Chen C. Y., Lee I. H., Kao W. T., Wang Y. C., A polymorphism in the hMLH1 gene (-93G→A) associated with lung
cancer susceptibility and prognosis // Int. J. Mol. Med. – 2010. – V. 25. – P. 165–170.
14 Harley I., Rosen B., Risch H. A., et al., Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1 // Gynecol. Oncol. – 2008. – V. 109. – P. 384–387.
15 Beiner M. E., Rosen B., Fyles A., Harley I., Pal T., Siminovitch K., Zhang S., Sun, P. and Narod, S. A., Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2 // Cancer Epidemiol. Biomarkers Preven. – 2006. – V.15. – P. 1636–1640.
16 Deng D. J., Zhou J., Zhu B. D., Ji J. F., Harper J. C., Powell S. M., Silencing-specific methylation and single nucleotide polymorphism
of hMLH1 promoter in gastric carcinomas // World J. Gastroenterol. – 2003. – V. 9. – P. 26–29.
17 Lee K. M., Choi J. Y., Kang C. et al., Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk // Clin. Cancer Res. – 2005. – V. 11. – P. 4620–4626.
18 Jha R., Gaur P., Sharma S.C, Das S. N. Single nucleotide polymorphism in hMLH1 promoter and risk of tobacco-related oral
carcinoma in high-risk Asian Indians //Gene. – 2013. In print.
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Zhunussova, G. S., Afonin, G. A., Zhunusbekova, B. B., Iksan, O. A., Djantaeva, K. B., Kaidarova, D. R., Parker, M. I., & Djansugurova, L. B. (2015). Association of MLH1-93G> A polymorphism with the risk of colorectal cancer in Kazakhstan population. Experimental Biology, 60(1), 88–92. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/64
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