The preclinical testing of the pharmacological remedy in the Dr. melanogaster test systems
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Keywords:
drosophila, lethal mutation, solderad X-chromosomes, Meller-5, gemizigota,Abstract
This article presents dates by studying mutagenicity of the pharmacological remedy – grossgemin in test systems Drosophila meksnjgaster: Muller-5 and X-linked chromosomes. Results of the using these methods are identical. The grossgemin mutagenic activity in concentrations of 5% in oral administration are not detected.References
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2 Ashby J. International Commission for protection against Environmenral Mutagens and Carcinogens. Two million rodent carcinogens. The role of SAR and QSAR in their detection. // Mutation Research. – 1994, Feb 1.- 305 (1). – P. 3-12.
3 Klopman G., Rozenkranz H.S. International Commission for protection against Environmenral Mutagens and Carcino genеs. Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MUL TI-CASE. //Mutation
Research, 1994, Feb 1, 305 (1), P. 33- 46.
4 Kuroda Y. Mutat. Res. Environ .// Mutagen. Related Subj.- 1987. -Vol. 182.- P. 365-370.
5 Бочков Н.П. Клиническая генетика. М., 2004. – 475с.
6 Дурнев А.Д. Генетическая токсикология // Вестник Российской
академии медицинских наук. – 2011. – № 9. – С. 35-43.
7 Абилев С.К. Химические мутагены и генетическая токсикология // Природа. – 2012. – № 10.- С. 39-46. 8 УДК 577.2:616-006
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Biyasheva, Z. M., Ryszhan, K. A., Kazykhanova, A. B., & Kerimkulova, A. B. (2015). The preclinical testing of the pharmacological remedy in the Dr. melanogaster test systems. Experimental Biology, 60(1), 84–87. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/63
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Biomedicine
