Взаимодействие miRNA семейства miR-1273 с mRNA генов, регулирующих клеточный цикл и апоптоз. Жасушалық цикл мен апоптозды реттейтін гендердің mRNA miR-1273 жиынтығының miRNA байланысуы

A. T Ivashchenko; Sh. A. Atambayeva; R. E. Niyazova

Authors

A. T Ivashchenko Национальная нанотехнологическая лаборатория КазНУ имени аль-Фараби,
Sh. A. Atambayeva Национальная нанотехнологическая лаборатория КазНУ имени аль-Фараби
R. E. Niyazova Национальная нанотехнологическая лаборатория КазНУ имени аль-Фараби

Keywords:

miRNA, gene, apoptosis, cell cycle, cancer

Abstract

It was shown that genes involved in cell cycle regulation and apoptosis, are targets for the miR-1273 family. ATM, TP53 and VHL genes regulate the cell cycle and apoptosis and their mRNA have binding sites with miR-1273 family. CLSPN, MDM2, NF2, TRIM13 and LZTS1 genes proteins involved in cell cycle regulation and their mRNA are also targets for the majority of the studied miRNA. SPN, CASP, STK4 and DFFB genes participate in the regulation of apoptosis and they are targets for miR-1273 family. Studied miRNA under the appropriate concentrations can greatly affect the expression of genes involved in cell cycle regulation and apoptosis.