Перспективы использования мезенхимальных стволовых клеток в терапии инсульта
DOI:
https://doi.org/10.26577/eb-2019-1-1379Аннотация
В настоящей обзорной статье приводятся и анализируются результаты завершенных и продолжающихся клинических исследований мезенхимальных стволовых клеток (MSC) в качестве безопасной и потенциально эффективной технологии терапии инсульта у людей. Инсульт, как известно, является основной причиной инвалидности трудоспособного населения. От четверти до половины переживших инсульт людей остаются со значительными нарушениями здоровья. Традиционные методы лечения приносят пользу лишь небольшой части пациентов. В настоящее время потенциальной регенеративной стратегией для пациентов с неврологическим дефицитом может служить терапия стволовыми клетками, в том числе, мезенхимальными стволовыми клетками. MSC, как известно, способны к самообновлению и дифференцировке в тканеспецифические клетки, участвуют в развитии, поддержании и восстановлении тканей, что привлекает к ним внимание как к потенциальным источникам в регенеративной терапии многих заболеваний, включая инсульт. MSC, путем включения в индукцию ангиогенеза, стимулирование нейрогенеза, иммуномодуляцию, предотвращение апоптоза, могут в значительной степени нивелировать патологические процессы, связанные с развитием инсульта. Анализ доклинических исследований, изучающих эффекты MSC-терапии после ишемического инсульта, показывает, что MSC благотворно влияют на восстановление от инсульта.
Ключевые слова: инсульт, мезенхимальные стволовые клетки, регенеративная терапия, терапия стволовыми клетками, растительные антиоксиданты.
Библиографические ссылки
Литература
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1. Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet. 2008;371:1612–1623.
2. NCHS Dataline Public Health Reports.126433.
3. Johnston SC, Mendis S, Mathers CD. Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling. Lancet Neurol. 2009;8:345–354.
4. Mauldin PD, Simpson KN, Palesch YY, Spilker JS, Hill MD, Khatri P, et al. Design of the economic evaluation for the Interventional Management of Stroke (III) trial. Int J Stroke. 2008;3:138–144.
5. Ansari S, Rahman M, Waters MF, Hoh BL, Mocco J. Recanalization therapy for acute ischemic stroke, part 1: surgical embolectomy and chemical thrombolysis. Neurosurg Rev. 2011;34:1–9.
6. Ansari S, Rahman M, McConnell DJ, Waters MF, Hoh BL, Mocco J. Recanalization therapy for acute ischemic stroke, part 2: mechanical intra-arterial technologies. Neurosurg Rev. 2011;34:11–20.
7. Adeoye O, Hornung R, Khatri P, Kleindorfer D. Recombinant tissue-type plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years. Stroke. 2011;42:1952–1955.
8. Trounson A. New perspectives in human stem cell therapeutic research. BMC Med. 2009;7:29.
9. Mohal JS, Tailor HD, Khan WS. Sources of adult mesenchymal stem cells and their applicability for musculoskeletal applications. Curr Stem Cell Res Ther. 2012;7:103–109.
10. Witkowska-Zimny M, Wrobel E. Perinatal sources of mesenchymal stem cells: Wharton's jelly, amnion and chorion. Cell Mol Biol Lett. 2011;16:493–514.
11. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA. 1999;96:10711–10716.
12. Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol. 2000;164:247–256.
13. Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views. Stem Cells. 2007;25:2896–2902.
14. Dharmasaroja P. Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke. J Clin Neurosci. 2009;16:12–20.
15. Sensebé L, Krampera M, Schrezenmeier H, Bourin P, Giordano R. Mesenchymal stem cells for clinical application. Vox Sang. 2010;98:93–107.
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2019-04-24
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