Выделение микроорганизмов из казахских кисломолочных продуктов с антагонистической активностью в отношении дрожжей рода Candida
DOI:
https://doi.org/10.26577/eb-2019-2-1421Аннотация
Рост числа кандидозов, повышение степени их тяжести и возрастающая устойчивость возбудителей к противогрибковым препаратам, а также их вредные побочные эффекты, вызывают необходимость выявления новых более эффективных и безопасных противогрибковых средств. В этом контексте большой интерес может представлять разработка и использование функциональных кисломолочных продуктов с микроорганизмами, обладающими противогрибковой активностью и способствующими выведению из организма оппортунистических дрожжей рода Candida. Микробиота казахских национальных кисломолочных напитков, полученных из кобыльего и верблюжьего молока, оказывает разностороннее воздействие на здоровье человека, но антагонистическая активность представителей этой микробиоты против видов дрожжей, ответственных за кандидоз, еще не изучена.
Целью настоящей работы было выделение из казахских национальных кисломолочных напитков микроорганизмов, антагонистически активных в отношении дрожжей рода Candida.
Исследование антагонистической активности различных образцов молочных и кисломолочных продуктов местного (как домашнего, так и коммерческого) производства в отношении C. albicans методом диффузии из лунок показало эффективное подавление роста дрожжей образцами кумыса домашнего изготовления. Ассоциации микроорганизмов различных образцов кумыса сохраняли антагонистическую активность при последовательных пересевах на коровьем молоке и молочной сыворотке. При культивировании на коровьем молоке эти ассоциации обладали повышенной активностью в отношении C. krusei 25. Наиболее высокую антагонистическую активность в отношении C. glabrata 589 проявили три ассоциации при культивировании на молочной сыворотке. После высева наиболее перспективных ассоциаций на среду MRS из колоний различных морфологических типов выделен 41 изолят бактерий, 28 из которых являются молочнокислыми бактериями, а остальные, предположительно, уксуснокислыми микроорганизмами. Выделено также 34 изолята дрожжей.
В наших исследованиях впервые выделены аборигенные штаммы молочнокислых микроорганизмов, ингибирующие рост дрожжей рода Candida, в том числе проявляющих высокую степень устойчивости, как к метаболитам молочнокислых бактерий (кишечные и вагинальные изоляты C. albicans), так и к противогрибковым антибиотикам (С. glabrata 589 и С. krusei 25). Отобранные микроорганизмы будут использованы для создания консорциумов и использования в качестве заквасок для функциональных напитков с противогрибковой активностью в отношении условно-патогенных дрожжей рода Candida.
Ключевые слова/словосочетания: кумыс, молочнокислые бактерии, анти-Candida. активность.
Библиографические ссылки
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6 Jyoti B., Suresh A.K., Venkatesh K. Diacetyl production and growth of Lactobacillus rhamnosus on multiple substrates // World J Microbiol Biotechnol. – 2003. – Vol. 19. – P. 509–515.
7 Lanciotti R., Patrignani F., Bagnolini F., Guerzoni M.E., Gardini F. Evaluation of diacetyl antimicrobial activity against Escherichia coli, Listeria monocytogenes and Staphylococcus aureus // Food Microbiol. – 2003. – Vol. 20. – P. 537–543.
8 Schnürer, J., Magnusson J. Antifungal lactic acid bacteria as biopreservatives // Trends Food Sci. Technol. – 2005. – Vol. 16. – P. 70–78.
9 Dalié D.K.D., Deschamps A.M., Richard-Forget F. Lactic acid bacteria—Potential for control of mould growth and mycotoxins: A review // Food Control. – 2010. – Vol. 21. – P. 370–380.
10 Crowley S., Mahony, J., van Sinderen D. Current perspectives on antifungal lactic acid bacteria as natural bio-preservatives // Trends Food Sci. Technol. – 2013. – Vol. 33. – P. 93–109.
11 Le Lay C., Coton E., Le Blay G., Chobert J. M., Haertlé Th., Choiset Y., Van Long N. N., Meslet-Cladière L., Mounier J. Identification and quantification of antifungal compounds produced by lactic acid bacteria and propionibacteria // International Journal of Food Microbiology. – 2016. - Vol. 239. – P. 79-85.
12 Pothuraju R., Sharma R.K. Interplay of gut microbiota, probiotics in obesity: a review // Endocrine, metabolic and immune disorders-drug targets. – 2018. – Vol. 18. – P. 212–220.
13 Vijayaram S., Kannan S. Probiotics: the marvelous factor and health benefits // Biomed Biotechnol Res J. - 2018. – Vol. 2. – P. 1–8.
14 Wagner R.D., Johnson S.J. Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans // J Biomed Sci. – 2012. – Vol. 19. – P. 58.
15 Ranadheera C.S., Evans C. A., Adams M. C., Baines S. K. Effect of dairy probiotic combinations on in vitro gastrointestinal tolerance, intestinal epithelial cell adhesion and cytokine secretion // J Funct Foods. – 2014. – Vol. 8. – P. 18–25.
16 Matsubara V. H., Wang Y., Bandara H. M., Mayer M. P., Samaranayake L. P. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation // Appl Microbiol Biotechnol. – 2016. – Vol. 100(14). – P. 6415-6426.
17 Tan Y., Leonhard M., Moser D., Ma S., Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm // Archives of Oral Biology. – 2018. –Vol. 85. – P. 40-45.
18 Aartia Ch., Khusroa A., Vargheseb R., Arasuc M. V., Agastiana P., Al-Dhabic N. A., Ilavenild S., Choid K. Ch. // In vitro investigation on probiotic, anti-Candida, and antibiofilm properties of Lactobacillus pentosus strain LAP1// Archives of Oral Biology. – 2018. - Vol. 89. - P. 99-106.
19 Cross M. L. Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens // FEMS Immunology and Medical Microbiology. – 2002. – Vol. 34, Issue 4. – P. 245-253.
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Как цитировать
Aitzhanova, A. A., Saubenova, M. G., Mounier, J., Oleinikova, E. A., & Berzhanova, R. Z. (2019). Выделение микроорганизмов из казахских кисломолочных продуктов с антагонистической активностью в отношении дрожжей рода Candida. Вестник КазНУ. Серия биологическая, 79(2), 54–63. https://doi.org/10.26577/eb-2019-2-1421
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