Paracrine regulators of colon cancer stem cells
57 41
Keywords:
cancer stem cells, microenvironment, inductors,Abstract
Cancer stem cells are main cause of cancer recurrence. For effective treatment it is necessary to understand haw survive and stimulate these cells. In this work it was estimated influence of cancer microenvironment to growth and surveillance of cancer. The main modulators of cancer are cancer associated miofibroblasts and macrophages, and also Th17 cells.References
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2 Croker A.K., Allan A.L. Cancer stem cells: implications for the progression and treatment of metastatic disease // J. Cell. Mol. Med. – 2008. – Vol. 12, №2. – P. 374-390.
3 Clevers H. Wnt/beta-catenin signaling in development and disease // Cell. – 2006. – Vol. 127. – P. 469–80.
4 Pinchuk I.V., Mifflin R. C., Saada J. I. et al. Intestinal Mesenchymal Cells // Curr Gastroenterol Rep. – 2010. – Vol. 12, № 5. – P. 310–318.
5 Vermeulen L., De Sousa E., Melo F. et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment // Nat Cell Biol. – 2010. – Vol. 12. – P. 468–76.
6 Shinagawa K., Kitadai Y., Tanaka M. et al Mesenchymal stem cells enhance growth and metastasis of colon cancer // Int. J. Cancer. – 2010. – Vol. 127. – P. 2323–2333.
7 Postovit L.M., Margaryan N.V., Seftor E.et al. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells // Proc Natl Acad Sci U S A. – 2008. – Vol. 105, № 11. – Р.4329-34.
8 Lin W.W., Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer // J Clin Invest. – 2007. – Vol.
117. – P. 1175–1183.
9 Zheng Y., Valdez P.A., Danilenko D.M. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial
pathogens // Nat. Med. – 2008. – Vol. 14. – P. 282–289.
10 Wu S., Rhee K.J., Albesiano E. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses // Nat Med. – 2009. – Vol. 15. – P. 1016-1022.
11 Schwaab T., Weiss J.E., Schned A.R. et al. Dendritic cell nfiltration in colon cancer // J Immunother. – 2001. – Vol. 24, № 2. – P. 130-7.
12 Rigo A., Gottardi M., Zamò A.Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12 // Mol Cancer. – 2010. – Vol. 9, № 273.
13 Kaler P., Augenlicht L., Klampfer L. Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3 // Oncogene. – 2009. – Vol. 28. – P. 3892–3902.
14 Hao N.-B., Lu M.-H, Fan Y.-H. et al. Macrophages in Tumor Microenvironments and the Progression of Tumors / Clin Dev Immunol. – 2012. – Vol. 2012, № 948098. – doi: 10.1155/2012/948098.
15 Onnis В., Fer N., Rapisarda A. et al Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells // J Clin Invest. – 2013. – Vol. 123, № 4. – Р. 1615–1629. – doi:10.1172/JCI59623.
16 Suzuki H., Ogawa H., Miura K. et al. IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma //Oncology Letters. – 2012. – Vol. 4, № 2. – P. 199-204.
17 Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes // Cell. – 2003. –Vol. 114. – P. 181–90.
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Issabekova, A. S., & Ogay, V. B. (2015). Paracrine regulators of colon cancer stem cells. Experimental Biology, 60(1), 98–101. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/66
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