Methorchosis in north Kazakhstan: state of study and distribution
DOI:
https://doi.org/10.26577/eb-2019-3-b15Abstract
In this article, the authors conducted a study of the state of knowledge and prevalence of methorchosis in the territory of Northern Kazakhstan. The domestic and foreign literature was analyzed, where the presence of the pathogen of methorchosis in Kazakhstan was noted, but studies were not conducted at the proper level. The authors of the article conducted studies of the intermediate and final hosts of the pathogens of the family Opisthorchiidae. Molecular genetic studies have shown in one of the intermediate hosts, fish of the cyprinid family, the presence of a mixed infection with the main species Opisthorchis felineus and Metorchis bilis. The obtained nucleotide sequences were registered in the international NCBI GenBank database. In addition, the presence of a mixed infection in one of the final hosts of representatives of wild carnivores (foxes) was proved. Marita were isolated from the liver, their morphological and molecular identification was carried out, as a result of which they belong to the species O. felineus and M. bilis. In the final study, the authors conducted biochemical and molecular-genetic studies of the blood serum of patients with a diagnosis of opisthorchiasis. The study showed that the incidence rate was 6.2% and these indicators are consistent with official statistics from open sources. The study of biological material selected from patients with a confirmed ELISA diagnosis of "opisthorchiasis", also allowed to prove mixed invasion in people in the study region.
Key words: PCR, methorchosis, opisthorchiasis, mixed invasion
References
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2. Beer S.A. (2005) Biologiya vozbuditelya opistorhoza [Biology of the pathogen opisthorchiasis]. – M.: Tovarischestvo nauchnyih izdaniy KMK. – 336 s. ISBN 5-87317-204-8.
3. Bogdashir M. (2017) Glistnyie invazii [Helminthic infestations] // Izd-vo Litres. – Moskva. – 231 s.
4. Brusentsov I.I., Katokhin A.V., Sakharovskaya Z.V., Sazonov A.E., Ogorodova L.M., Fedorova O.S. et al. (2010) DNA diagnosis of mixed invasions of Opisthorchis felineus and Metorchis bilis by polymerase chain reaction. // Med. Parazitol. (Mosk). – Vol. 2. – P. 10-13. ISBN 0025-8326.
5. Cameron T.W.M. (1944) The Morphology, Taxonomy, and Life History of Mеtorchis conjunсtus. // Can J Res. – Vol. 22d. – P 6-16.
6. Fedorov K.P., Naumov V.A., Kuznetsova V.G., Belov G.F. (2000) O nekotoryih aktualnyih voprosah problemyi opistorhidozov cheloveka [On some topical issues of the problem of human opisthorchidiasis]. // Med. Parazit. i parazitar. bolezni. – # 3. – S. 7-9. ISBN 0025-8326.
7. Iliinskih E.N., Nowisci V.V., Iliinski N.N., Lepehin A.V. (2007) Infestations Opisthorchis felineus (Rivolta, 1884) and Metorchis bilis (Braun, 1890) a person in different regions of the Ob-Irtysh river basin. // Parasitology. – Vol. 41(1). P. 55-64. ISSN:0031-1847
8. Kiyan V.S., Bulashev A.K., Katokhin A.V. (2018) Opisthorchis felineus and Metorchis bilis Metacercariae in Cyprinid Fish Leuciscus idus in Nura-Sarysu River, Kazakhstan. // Korean J Parasitol. – Vol. 56 (3). – P. 267-274. doi: 10.3347/kjp.2018.56.3.267.
9. Kosherova B.N., Kusainova A.S., Syizdyikov M.S., Baesheva D.A., Alisheva G.L. (2009) Epidemiologicheskaya harakteristika opistorhoza u ryib na primere vodoemov Akmolinskoy oblasti [Epidemiological characteristics of opisthorchiasis in fish on the example of water bodies in Akmola region] // Meditsina i ekologiya. – #3 (52). – S. 29-32. ISBN 2305-6045.
10. Kuznetsova V.G., Naumov V.A., Belov G.F. (2000) Methorchiasis in the residents of Novosibirsk area, Russia. // Cytobios. – Vol. 102. – P. 33-44. ISBN : 0011-4529
11. Lin, J.X., Cheng, Y.Z., Li, Y.S., Xu, S.L., Lin, C.X., Chen, B.J., Xiu, W.Q., Zhang, R.Y., Zhu, K., Li, L.,Pan, L.X., Yao, L.Z., Ling, G.H. (2001) The discovery of natural infection of human with Mеtorchis orientalis and the investigation of its focus. // Chin. J. Zoonoses.– Vol.17. – P 19-20 [In Chinese]. ISBN 0007-4845.
12. Mihaleva E.V. (2005) Veterinarno-sanitarnaya otsenka opistorhoznoy ryibyi i farmakologicheskiy effekt preparata Sausurea amara pri opistorhoze sobak [Veterinary and sanitary assessment of opisthorchiasis fish and pharmacological effect of Sausurea amara in dogs opisthorchiasis]: avtoref. … kand. biol. nauk: 16.00.06. – Kazan: Pechatnyiy dvor. – 22 s.
13. MKB-10: Mezhdunarodnaya statisticheskaya klassifikatsiya bolezney i problem, svyazannyih so zdorovem. (1995) Vsemirnaya organizatsiya zdravoohraneniya [International Statistical Classification of Diseases and Health Problems. World Health Organization]. – Tom 1: Chast 2. – 633 c. ISBN 5225032680_2.
14. Mordvinov V.A., Yurlova N.I., Ogorodova L.M., Katokhin A.V. (2012) Opisthorchis fеlineus and Mеtorchis bilіs are the main agents of liver fluke infection of humans in Russia. // Parasitol Int. – Vol. 61. – P 25-31. doi: 10.1016/j.parint.2011.07.021.
15. Müller B., Schmidt J., Mehlhorn H. (2007) Sensitive and species-specific detection of Clonorchis sinensis by PCR in infected snails and fishes \\ Parasitol Res. – Vol. 100. – P. 911-914. DOI: 10.1007/s00436-006-0322-9.
16. Nöckler K., Dell K., Schuster R., Voigt W.P. (2003) Indirect ELISA for the detection of antibodies against Opisthorchis felineus (Rivolta, 1884) and Metorchis bilis (Braun, 1790) in foxes. // Vet Parasitol. – Vol. 110. – P. 207-215.
17. Sbornik materialov «Sanitarno-epidemiologicheskaya situatsiya v Respublike Kazahstan za 2015 god». (2015) Komitet po zaschite prav potrebiteley MNE RK, RGP na PHV «Nauchno-prakticheskiy tsentr sanitarno epidemiologicheskoy ekspertizyi i monitoringa» KZPP MNE RK [Collection of materials “Sanitary and epidemiological situation in the Republic of Kazakhstan for 2015”]. – Astana. – 94 s.
18. Schuster R.K. Opisthorchiidosis - a review // Infect. Disord. Drug Targets. – 2010. – Vol. 10. – P. 402-415. ISBN: 1871-5265.
19. Schuster R., Gregor B., Heidrich J., Nockler K., Kyule M. Wittstatt U. (2003) A sero-epidemiological survey on the occurrence of opisthorchiid liver flukes in red foxes (Vulpes vulpes)
in Berlin, Germany // Parasitol Res. – Vol. 90. – P. 400-404. DOI: 10.1007/s00436-003-0868-8.
20. Sherrard-Smith E., Stanton D.W.G., Cable J., Orozco-ter-Wengel P., Simpson V.R., Elmeros M., J. van Dijk, Simonnet F., Roos A., Lemarchand C., Poledník L., Heneberg P., Chadwick E.A. (2016) Distribution and molecular phylogeny of biliary trematodes (Opisthorchiidae) infecting native Lutra lutra and alien Neovison vison across Europe // Parasitol. Int. – Vol. 65. – P. 163-170. doi: 10.1016/j.parint.2015.11.007.
21. Sitko J., Bizos J., Sherrard-Smith E., Stanton D.W., Komorová P., Heneberg P. (2016) Integrative taxonomy of European parasitic flatworms of the genus Metorchis Looss, 1899 (Trematoda: Opisthorchiidae) // Parasitol. Int. – Vol. 65. – P. 258-267. doi: 10.1016/j.parint.2016.01.011.
22. Sidorov E.G. (1983) Prirodnaya ochagovost opistorhoza [Natural foci of opisthorchiasis]. – Alma-Ata: Nauka. – 240 s. ISBN 0031-1847.
23. Skryabin K.I. (1928) Metod polnyih gelmintologicheskih vskryitiy pozvonochnyih, vklyuchaya cheloveka [Method for complete helminthological dissections of vertebrates, including humans]. – G.: Izd-vo 1-go Mosk. gos. un-ta. – S. 43.
24. Sultanov A., Abdybekova A., Abdibaeva A., Shapiyeva Z., Yeshmuratov T., Torgerson P.R. (2014) Epidemiology of fish-borne trematodiasis in Kazakhstan // Acta Trop. – Vol. 138. – P. 60-66. doi: 10.1016/j.actatropica.2014.04.030.
25. Yurlova N.I., Yadrenkina E.N., Rastyazhenko N.M., Serbina E.А., Glupov V.V. (2017) Opisthorchiasis in Western Siberia: Epidemiology and distribution in human, fish, snail, and animal populations // Parasitol. Int. – Vol. 66(4). – P. 355-364. doi: 10.1016/j.parint.2016.11.017.
26. Zadesenets K.S., Polyakov A.V., Katokhin A.V., Mordvinov V.A., Rubtsov N.B. (2017) Chromosome morphometry in opisthorchiid species (Platyhelminthes, Trematoda). // Parasitology International. – Vol. 66. – P. 396-401. doi: 10.1016/j.parint.2016.07.004.
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Kiyan, V. S., Smagulova, A. M., & Katokhin, A. V. (2020). Methorchosis in north Kazakhstan: state of study and distribution. Experimental Biology, 80(3), 170–179. https://doi.org/10.26577/eb-2019-3-b15
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