Study of therapeutic and prophylactic activity of complex herbal preparation "Immuvir"
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Keywords:
plant antiviral preparation, preventive, therapeutic activity,Abstract
Viral infections are still one and the main problems of humanity, threatening human health and life, as well as causing enormous economic damage . One way to solve this problem is the search for and development of fundamentally new, highly effective antiviral preparations. The aim of this work was the comparative study preventive and therapeutic activity of complex herbal preparation " Immuvir " and commercial drugs: ribavirin, geviran, rimantadine against influenza virus A/FPV/Rostock/34 strain in experiments on chickens. As a result of studies , it was found that the activity of the preparation "Immuvir" is comparable with therapeutic activity of preparation ribavirin and exceeds the therapeutic and prophylactic activity of geviran and rimantadine preparations.References
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2 Bernet J., Mullick J., Singh A.K., Sahu A. Viral mimicry of the complement system // J. Biosci. – 2003. – №3. – P. 249-264.
3 Monto A.S. Antivirals and influenza: frequency of resistance // Pediatr Infect Dis J. – 2008. – Vol. 10. – P. 110-122.
4 Yamashita M., Tomozawa T., Kakuta M., Tokumitsu A., Nasu H., Kubo S. CS-8958, a prodrug of the new neuraminidaseinhibitor R-125489, shows long-acting anti-influenza virus activity // Antimicrob. Agents Chemother. – 2008. – Vol.5. – P. 343-350.
5 Chen C., Ron Y. New strategies for immune-mediated anti-viral drug and vaccine development // Curr. Pharm. Des. – 2006. – Vol.12, №11. – P.1391-401.
6 Alcami A. Viral mimicry of cytokines, chemokines and their receptors // Nat. Rev. Immunol. – 2003. – Vol.3, №1. – P. 36-50.
7 Reed L., Muench H. A simple method of estimating fifty percent endpints // Amer.J. Hyg. – 1938. – Vol. 27. – P. 493-497.
8 Закстельская Л.Я., Шендерович С.Ф. Метод удаления неспецифических ингибиторов гемагглютинации из диагностических и постинфекционных сывороток // Вопросы вирусологии. – 1979. – №5. – С. 560-561.
9 Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding // Anal.Biochem. – 1976. – Vol.72. - № 1. – Р. 248-254.
10 Chucholowius H., Rott R. A new method for purification of myxoviruses by zonal centrifugation with two different sucrose density gradients // Proc. Soc. Exp. Biol. Med. – 1972. – Vol. 8. – P. 295-297.
11 Урбах В.Ю. Статистический анализ в биологических и медицинских исследованиях. - М.: Медицина, 1975. –296 с
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Alexyuk, P. G., Zaitseva, I. A., Alexyuk, M. S., Sokolova, N. S., Turmagambetova, A. S., Bogoyavlenskyi, A. P., & Berezin, V. E. (2015). Study of therapeutic and prophylactic activity of complex herbal preparation "Immuvir". Experimental Biology, 60(2), 149–152. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/148
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BIOTECHNOLOGY
