"153Sm-EDTMР, solution for therapy" was tested on rats in the experimental study in radioactivity equivalent to human.
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Keywords:
radionuclide therapy, bone metastases, experimental study, equivalent radioactivity, periferal blood, bone marrow.Abstract
The article presents the results of tests on rats new domestic osteotropic drug "153Sm-EDTMP, solution for therapy", produced by the Institute of nuclear physics, intended for radionuclide therapy of metastases of malignant tumors and inflammation in the bones. Studied the picture of peripheral blood and bone marrow in 7 subjects who entered the dose of radioactivity "153Sm-EDTMP, solution for therapy", is equivalent to man and 5 intact control rats. Indicators median hemoglobin, a color indicator, segmented neutrophils and leukocytes were higher and platelets, monocytes, and lymphocytes from subjects less rats than in the controls. Marked thrombocytopenia, as one of the signs of the damaging effect of radiation on the organism, in rats that received radioactive. In the red bone marrow of the subjects of the rats revealed an increase in cellularity, changes in the ratios of the germs of hematopoiesis, the extension of the red Rostock dyserythropoiesis, increased number of megakaryocytes. Platelets were ethnoregionalist in sufficient quantity and type of hematopoiesis normoblasticheskuyu as in the control rats.References
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References
1. Tsyb A.F., Drozdovskii B.Y. Radionuclide therapy. Experience, mail aspects, perspectives. Atom Strategy of XXI, december. –2003. –14 p.
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2. Наркевич Б.Я., Ширяев С.В. Методические основы радионуклидной терапии. // Мед.радиол. рад. безопасность, –2003. –49. –№ 5. –С. 35–44.
3. Радионуклиды для терапии. В кн.: Ядерная медицина. Учебное пособие. I часть. Переводс немец. Под ред. к.м.н. О.Е. Шлыгиной, А.Р. Борисенко. –Алматы, 2008. –С.38-39.
4. Терапия открытыми радиоактивными веществами. В кн.: Ядерная медицина. Учебное пособие. II часть. Перевод с немец. Под ред. к.м.н. О.Е. Шлыгиной, А.Р. Борисенко. –Алматы, 2008. –С.273-278.
5. Основы статистического анализа и его применения в медицине и общественном здравоохранении. Учебно-методическое пособие по курсу «Общественное здравоохранение». –Алматы, 2003. –60 с.
References
1. Tsyb A.F., Drozdovskii B.Y. Radionuclide therapy. Experience, mail aspects, perspectives. Atom Strategy of XXI, december. –2003. –14 p.
2. Narkevich B.Y., Shiryaev S.V. Methodical base of radionuclide therapy. // Medical radiology and radiological safety, –2003. –49. –№ 5. –Р. 35–44.
3. Radionuclide therapy. Nuclear Medicine. Teaching file. Book I. Translated from Dutch by О.Е. Shlygina, А.R. Borisenko. –Almaty, 2008.–Р. 38-39.
4. Therapy with open source radiation. Nuclear Medicine. Teaching file. Book II. Translated from Dutch by О.Е. Shlygina, А.R. Borisenko.–Almaty, 2008. –Р. 273-278.
5. Fundamentals of statistic analysis and use in medicine and public health. Teaching file in Public health. –Almaty, 2003. –60 p.
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Nietbayeva, O. V., Mashrapova М. М., Kunanbayeva А. B., Kushmanov Е. Е., Kerimbekova, G. Z., Мyrzabaeva G. B., & Tazhedinov, I. (2016). "153Sm-EDTMР, solution for therapy" was tested on rats in the experimental study in radioactivity equivalent to human. Experimental Biology, 66(1), 88–96. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/1164
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HUMAN AND ANIMAL PHYSIOLOGY
