Effect of α-lipoic acid on immune parameters in rats
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Keywords:
α- lipoic acid, rats, immunological parameters, initial form, control group.Abstract
Nowadays the actual problems is to change the environment that violates human vital organs like the brain, heart, liver. Currently used in many products lipoic acid is widely used against intoxication. Lipoic acid with antioxidant properties to positively influence the organism tserroz hepatitis and liver play an important rule in lipid metabolism and choleretic, antispasmodic action and stands as building immunity. A lipoic acid also helps absorbed antioxidants (e.g., vitamins A and E) that were received in the body. Aim of this work to study the effect of α-lipoic acid on immune parameters.References
Пайдаланылған әдебиеттер:
1. Барабой В.А. Альфа-липоевая - дигидролипоевая кислоты - активная биоантиоксидантная и биорегуляторная система // Укр. біохім. журн. - 2005. - Т. 77, № 3. - С. 20-26.
2. Bilska A., Wlodek L. Lipoic acid - the drug of the future? // Pharmacol. Rep. - 2005. - Vol. 57. - P. 570-577.
3. Стаховская Л.В., Алехин А.В., Гусева О.И. Клиническое применение препаратов липоевой кислоты // Справочник поликлинич. врача. - 2007. - № 5. - С. 1-6.
4. Abdel-Zaher A.O., Abdel-Hady R.H., Mahmoud M.M. et al. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology. 2008 Jan 20; 243(3): 261–70.
5. DCCT Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy // Ann. Intern. Med. – 1995. –V.122. – P. 561–568
6. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant α-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study) // Diabetologia. – 1995. –V.38. – P.1425–1433
7. Barja G. Free radicals and aging // Trends Neurosci. - 2004. - Vol. 27. - P. 595-600.
8. Miquel J. Can antioxidant diet supplementation protect against age-related mitochondrial damage? // Ann. N.Y. Acad. Sci. - 2002. - V.959. - P.508-516.
References
1. Baraboy B.A. Alfa-lipoevaia-digidrolipoevaia kisioly-activnaya bioantiocsidantnaya I bioregulyatornaya systema//Ukr.biochim.zhurn.-2005. –T.77.- №3. P.20-26
2. Bilska A., Wlodek L. Lipoic acid - the drug of the future? // Pharmacol. Rep. - 2005. - Vol. 57. - P. 570-577.
3. Stahovskaya L.B., Alehin A.B., Guseva O.I., Clinicheskoe primenenie preparatov lipoevoi kisloty // Spravochnik policlinich.vracha.-2007.- №5. P.1-6.
4. Abdel-Zaher A.O., Abdel-Hady R.H., Mahmoud M.M. et al. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology. 2008 Jan 20; 243(3): 261–70.
5. DCCT Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy // Ann. Intern. Med. – 1995. –V.122. – P. 561–568
6. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant α-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study) // Diabetologia. – 1995. –V.38. – P.1425–1433
7. Barja G. Free radicals and aging // Trends Neurosci. - 2004. - Vol. 27. - P. 595-600.
8. Miquel J. Can antioxidant diet supplementation protect against age-related mitochondrial damage? // Ann. N.Y. Acad. Sci. - 2002. - V.959. - P.508-516.
1. Барабой В.А. Альфа-липоевая - дигидролипоевая кислоты - активная биоантиоксидантная и биорегуляторная система // Укр. біохім. журн. - 2005. - Т. 77, № 3. - С. 20-26.
2. Bilska A., Wlodek L. Lipoic acid - the drug of the future? // Pharmacol. Rep. - 2005. - Vol. 57. - P. 570-577.
3. Стаховская Л.В., Алехин А.В., Гусева О.И. Клиническое применение препаратов липоевой кислоты // Справочник поликлинич. врача. - 2007. - № 5. - С. 1-6.
4. Abdel-Zaher A.O., Abdel-Hady R.H., Mahmoud M.M. et al. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology. 2008 Jan 20; 243(3): 261–70.
5. DCCT Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy // Ann. Intern. Med. – 1995. –V.122. – P. 561–568
6. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant α-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study) // Diabetologia. – 1995. –V.38. – P.1425–1433
7. Barja G. Free radicals and aging // Trends Neurosci. - 2004. - Vol. 27. - P. 595-600.
8. Miquel J. Can antioxidant diet supplementation protect against age-related mitochondrial damage? // Ann. N.Y. Acad. Sci. - 2002. - V.959. - P.508-516.
References
1. Baraboy B.A. Alfa-lipoevaia-digidrolipoevaia kisioly-activnaya bioantiocsidantnaya I bioregulyatornaya systema//Ukr.biochim.zhurn.-2005. –T.77.- №3. P.20-26
2. Bilska A., Wlodek L. Lipoic acid - the drug of the future? // Pharmacol. Rep. - 2005. - Vol. 57. - P. 570-577.
3. Stahovskaya L.B., Alehin A.B., Guseva O.I., Clinicheskoe primenenie preparatov lipoevoi kisloty // Spravochnik policlinich.vracha.-2007.- №5. P.1-6.
4. Abdel-Zaher A.O., Abdel-Hady R.H., Mahmoud M.M. et al. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology. 2008 Jan 20; 243(3): 261–70.
5. DCCT Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy // Ann. Intern. Med. – 1995. –V.122. – P. 561–568
6. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant α-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study) // Diabetologia. – 1995. –V.38. – P.1425–1433
7. Barja G. Free radicals and aging // Trends Neurosci. - 2004. - Vol. 27. - P. 595-600.
8. Miquel J. Can antioxidant diet supplementation protect against age-related mitochondrial damage? // Ann. N.Y. Acad. Sci. - 2002. - V.959. - P.508-516.
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Kaliaskarova, A. M., Atanbaeva, G. K., & Kolbay, I. S. (2016). Effect of α-lipoic acid on immune parameters in rats. Experimental Biology, 64(2), 170–173. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/1080
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HUMAN AND ANIMAL PHYSIOLOGY
