Взаимодействие miRNA с mRNA генов клеточного цикла при раке легкого. Өкпе обыры кезінде miRNA-дың жасушалық циклдің гендерінің mRNA-мен байланысуы

A. T. Ivashchenko; O. A. Berillo; R. Y. Niyazova; A. K. Shylmyrzayeva

Authors

A. T. Ivashchenko Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби,
O. A. Berillo Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби,
R. Y. Niyazova Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби,
A. K. Shylmyrzayeva Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби,

Keywords:

miRNA, mRNA, binding sites, target genes, cell cycle,

Abstract

It was studied binding of miRNAs with mRNAs of genes involved in the cell cycle. miRNAs binding with high efficiency with mRNAs of genes involved in the cell cycle were established. miR-619-5p, miR- 1273f, miR-1273g-3p, miR-574-5p, miR-3960, miR-619-5p, miR-1273e, miR-5096 and miR-5095 can bind with mRNA of several genes. Unique miRNAs can dominantly influence on the expression of the essential parts of human protein-coding genes, including cell cycle genes. Multiple binding sites of some miRNAs demonstrate high interaction between them and genes expression. We offer using unique miRNAs as tumorigenesis markers based on the results of the interaction of miRNAs and target genes. The characteristics of the interaction of miRNA with mRNA of the cell cycle genes in lung cancer are discussed.