Взаимодействие miRNA с mRNA генов апоптоза при раке легкого. Өкпе обыры кезінде miRNA-дың апоптоз гендерінің mRNA-мен байланысуы

A. T. Ivashchenko; O. A. Berillo; R. Y. Niyazova; D. V. Zadubenko

Authors

A. T. Ivashchenko Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби
O. A. Berillo Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби
R. Y. Niyazova Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби
D. V. Zadubenko Национальная нанотехнологическая лаборатория КазНУ им. аль-Фараби

Keywords:

miRNA, mRNA, binding sites, target genes, apoptosis,

Abstract

Binding of miRNAs with mRNAs of genes involved in apoptosis were studied. It has been established that several miRNAs have binding sites with mRNA of a single gene and one miRNA can binds with mRNAs of several genes. These miRNAs are miR-619-5p, miR-1273g-3p, miR-1273h-3p, miR-5096, miR-5095 and miR-5585-5p. Expression of the most of key genes of apoptosis may regulated by using miRNAs. On the basis of miRNAs with mRNAs of genes involved in apoptosis is recommended to use miRNAs acting on the expression of several genes as markers of carcinogenesis. The expression of some miRNAs in different subtypes of lung cancer is correlated with the expression of their target genes. The characteristics of the interaction of miRNAs with mRNAs of genes of apoptosis in lung cancer are discussed.