Метаболическая активность микробиоты кишечника и ожирение.Ішек микробиотының метаболиттік белсенділігі жəне семіздік
Ключевые слова:
Микробиота, ожирение, воспаление, Toll-подобные рецепторы.Микробиота, семіздік, қабыну, Toll-тəрізді рецепторларАннотация
Обсуждается возможный вклад кишечной микрофлоры в развитие хронических воспалительных процессов,ожирения и сопровождающих его метаболических расстройств. Созылмалы қабыну процесстерінің, семіздіктің жəне оның салдарынан туындайтын қосалқы метоболиттік бұзылыстардың дамуына ішек микрофлорасының тигізетін үлесі талқыланадыБиблиографические ссылки
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induced by diets high insaturated fat // Obesity. – 2008. - Vol. 16. - №6. – Р.1248–1255, 2008.
11. Lassenius, K. H. Pietilainen, K. Kaartinen, et al. Bacterial endotoxin activity in human serum is associated with
dyslipidemia, insulin resistance, obesity, and chronic inflammation // Diabetes Care. – 2011. - Vol.34. - №8. – Р.1809–1815.
12. Vijay-Kumar M., Aitken J.D. , Carvalho F.A. et al. Metabolic syndrome and altered gut microbiota in mice lacking
toll-like receptor 5 // Science. – 2010. - Vol.328. - №5975. – Р.228–231.
13. Bjursell M., Admyre T., Göransson M. et al. Improved glucose control and reduced body fat mass in free fatty acid
receptor 2-deficient mice fed a high-fat diet // Am. J. Physiol. – 2011. - Vol. 300. - №1. – Р. E211–E220.
14. Amar J., Chabo C., Waget A. et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early
onset of type 2 diabetes: molecular mechanisms and probiotic treatment // EMBO Mol. Med. – 2011. - Vol. 3. - №9. – Р.559–
572.
2. Collins C.D., Purohit S., Podolsky R.H., Zhao H.S., Schatz D. et al. The application of genomic and proteomic
technologies in predictive, preventive and personalized medicine // Vascul Pharmacol. - 2006. - Vol. 45. - №5. – Р. 258-267.
3. O’Hara A.M., Shanahan F. The gut flora as a forgotten organ // EMBO. -2006. - Vol. 7. - №7. - Р.688-693.
4. Бондаренко В.М., Гинцбург А.Л., Лиходед В.Г. Роль инфекционного фактора в патогенезе атеросклероза //
Эпидемиол. инф. болезни. - 2011. - № 2. – С.7-9.
5. Bäckhed F., Manchester J.K., Semenkovich C.F., Gordon .J.I. Mechanisms underlying the resistance to diet-induced
obesity in germ-free mice // Proc.Nat. Acad. Sci. USA. – 2007. - Vol.104. – №3. – Р. 979–984.
6. Turnbaugh P.J.,Ley R.E., Mahowald M.A. et al. An obesity-associated gut microbiome with increased capacity for
energy harvest // Nature. – 2006. - Vol. 444. - №7122. – Р.1027–1031
.
7. Zhang A., Zhang M., Wang S. et al. Interactions between gut microbiota, host genetics and diet relevant to development
of metabolic syndromes in mice // ISME J. – 2010. - Vol.4. - №2. – Р. 232–241.
8. Murphy E.F., Cotter P.D., Healy S. et al. Composition and energy harvesting capacity of the gut microbiota:
relationship to diet, obesity and time in mouse models // Gut. – 2010. - Vol.59. - №12. – Р.1635–1642.
9. Cani P.D., Amar J, Iglesias M.A. et al. Metabolic endotoxemia initiates obesity and insulin resistance // Diabetes. –2007. - Vol. 56. - №7. – Р. 1761–1772.
10. Davis J.E., Gabler N.K., Walker-Daniels J., Spurlock M.E. Tlr-4 deficiency selectively protects against obesity
induced by diets high insaturated fat // Obesity. – 2008. - Vol. 16. - №6. – Р.1248–1255, 2008.
11. Lassenius, K. H. Pietilainen, K. Kaartinen, et al. Bacterial endotoxin activity in human serum is associated with
dyslipidemia, insulin resistance, obesity, and chronic inflammation // Diabetes Care. – 2011. - Vol.34. - №8. – Р.1809–1815.
12. Vijay-Kumar M., Aitken J.D. , Carvalho F.A. et al. Metabolic syndrome and altered gut microbiota in mice lacking
toll-like receptor 5 // Science. – 2010. - Vol.328. - №5975. – Р.228–231.
13. Bjursell M., Admyre T., Göransson M. et al. Improved glucose control and reduced body fat mass in free fatty acid
receptor 2-deficient mice fed a high-fat diet // Am. J. Physiol. – 2011. - Vol. 300. - №1. – Р. E211–E220.
14. Amar J., Chabo C., Waget A. et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early
onset of type 2 diabetes: molecular mechanisms and probiotic treatment // EMBO Mol. Med. – 2011. - Vol. 3. - №9. – Р.559–
572.
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СОВРЕМЕННЫЕ ПРОБЛЕМЫ БИОМЕДИЦИНЫ И БИОФИЗИКИ
