Генетический профиль, метаболический синдром и риск развития рака молочной железы среди женщин Казахстана
DOI:
https://doi.org/10.26577/eb-2018-1-1317Аннотация
Работа посвящена исследованию связи рака молочной железы с метаболическим синдромом и генами, участвующими в метаболизме липидов. В рамках данного исследования нами были рекрутированы 136 участников с диагнозом РМЖ и 83 условно здоровых участников контрольной группы. Среди заболеваний, сопутствующих раку молочной железы, преобладают артериальная гипертензия, хронический бронхит, ишемическая болезнь сердца, миома матки, холецистит, варикозное расширение вен нижних конечностей, панкреатит. Встречаемость сахарного диабета 2-го типа составила 13,2%. Биохимический анализ на 18 метаболических показателей показал, что в группе больных по сравнению с контрольной группой уровень гомоцистеина и витамина В12 значительно превышает нормы. Анализ данных показал высокую корреляцию уровня гомоцистеина с риском развития рака молочной железы (ОШ = 15,29; ДИ = 5,67-41,28; р<0,001) в исследуемой группе. При исследовании ассоциации полиморфизмов исследуемых генов с риском развития РМЖ среди женщин Казахстана выявлено протективное воздействие в генах FTO, PRKAA2 и STK11. В случае гена CRTC2 в сверх доминантной модели выявлена ассоциация с риском развития РМЖ (ОШ=1,95; ДИ = 1,1-3,46; р=0,021). При исследовании связи между генетическим профилем и метаболическими показателями было выявлено, что генотип С/С (дикий) гена PRKAA2 может влиять на увеличение уровня холестерина при нормальных показателях витамина В12 (ОШ=3,43; ДИ = 1,25-9,39: р<0.015) и генотип Т/С влиять на увеличение холестерина при повышенных показателях витамина В12 (ОШ=3,23; ДИ = 1,1-9,52: р<0.035). Из данных анализа следует, что уровень гомоцистеина может быть использован как биомаркер, входящий в состав комплекса диагностических мер при раке молочной железы. К тому же, генотипы С/С и Т/С гена PRKAA2 могут быть использованы как маркеры уровней холестерина и витамина В12 в организме. Для исследования ассоциации других генов с биохимическими показателями и риском развития РМЖ необходимо увеличение выборки.
Ключевые слова: рак молочной железы, метаболический синдром, генетический профиль.
Библиографические ссылки
1 Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 // Int J Cancer. – 2015. – Vol. 136, No. 5, - P. e359-86. doi: 10.1002/ijc.29210.
2 Howlader N. National Cancer Institute. Breast Cancer Risk Factors. http://www.cancer.gov/ cancertopics/wyntk/breast/page4.
3 Grundy S.M., Brewer H.B. Jr., Cleeman J.I., Smith S.C. Jr, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition // Circulation. – 2004. – Vol. 109, No. 3. – P. 433–438.
4 Reaven G.M. Role of insulin resistance in human disease // Diabetes. – 1988. – Vol. 37, No. 12. – P. 1595–1607.
5 World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation. Geneva, Switzerland: World Health Organization, 1999.
6 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report // Circulation. – 2002. – Vol. 106, No. 25. – P. 3143–3421.
7 Grundy S.M. Metabolic syndrome pandemic // Arteriosclerosis, Thrombosis, and Vascular Biology. – 2008. – Vol. 28. – P. 629–636.
8 Esposito K., Chiodini P., Capuano A., et al. Metabolic syndrome and postmenopausal breast cancer: systematic review and meta-analysis // Menopause. – 2013. – Vol. 20, No. 12. – P. 1301–1309.
9 Osaki Y., Taniguchi S.I., Tahara A., Okamoto M., Kishimoto T. Metabolic syndrome and incidence of liver and breast cancers in Japan // Cancer Epidemiology. – 2012. – Vol. 36, No. 2. – P. 141–147.
10 Rosato V., Bosetti C., Talamini R., et al. Metabolic syndrome and the risk of breast cancer in postmenopausal women // Annals of Oncology. – 2011. – Vol. 22, No. 12. – P. 2687–2692.
11 van den Brandt P.A., Spiegelman D., Yaun S.-S., et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk // American Journal of Epidemiology. – 2000. – Vol. 152, No. 6. – P. 514–527.
12 Harvie M., Hooper L., Howell A.H. Central obesity and breast cancer risk: a systematic review // Obesity Reviews. – 2003. – Vol. 4, No. 3. – P. 157–173.
13 Michels K.B., Solomon C.G., Hu F.B., et al. Type 2 diabetes and subsequent incidence of breast cancer in the nurses' health study // Diabetes Care. – 2003. – Vol. 26, No. 6. – P. 1752–1758.
14 Ursin G., Longnecker M.P., Haile R.W., et al. A meta-analysis of body mass index and risk of premenopausal breast cancer // Epidemiology. – 1995. – Vol. 6, No. 2. – P. 137–141.
15 de Waard F., Baanders van Halewijn E.A. A prospective study in general practice on breast cancer risk in postmenopausal women // International Journal of Cancer. – 1974. – Vol. 14, No. 2. – P. 153–160.
16 Mink P.J., Shahar E., Rosamond W.D., et al. Serum insulin and glucose levels and breast cancer incidence: the atherosclerosis risk in communities study // The American Journal of Epidemiology. – 2002. – Vol. 156, No. 4. – P. 349–352.
17 Tornberg S.A., Holm L.-E., Carstensen J.M. Breast cancer risk in relation to serum cholesterol, serum beta-lipoprotein, height, weight, and blood pressure // Acta Oncologica. – 1988. – Vol. 27, No. 1. – P. 31–37.
18 Soler M., Chatenoud L., Negri E., Parazzini F., Franceschi S., La Vecchia C. Hypertension and hormone-related neoplasms in women // Hypertension. – 1999. – Vol. 34, No. 2. – P. 320–325.
19 Largent JA, McEligot AJ, Ziogas A. Hypertension, diuretics and breast cancer risk // Journal of Human Hypertension. – 2006. – Vol. 20, No. 10. – P. 727–732.
20 Rose D.P., Haffner S.M., Baillargeon J. Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women // Endocrine Reviews. – 2007. – Vol. 28, No. 7. – P. 763–777.
21 Liao S., Li J., Wei W. Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature // Asian Pacific Journal of Cancer Prevention. – 2011. – Vol. 12, No. 4. – P. 1061–1065.
22 Jarde T., Perrier S., Vasson M.P. Molecular mechanisms of leptin and adiponectin in breast cancer // European Journal of Cancer. – 2011. – Vol. 47, No. 1. – P. 33–43.
23 Goldberg J.E., Schwertfeger K.L. Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics // Current Drug Targets. – 2010. – Vol. 11, No. 9. – P. 1133–1146.
24 Fei X. and Michels K.B. Diabetes, metabolic syndrome and breast cancer: a review of the current evidence // Am. J. Clin. Nutr. – 2007. – Vol. 86. – P. 823-835.
25 King M.W. AMPK: Master Metabolic Regulator // Medical Biochemistry. http://themedicalbioche- mistry page.org/ampk.php.
26 Motoshima H., Goldstein B.J., Igata M., Araki E. AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer // J. Physiol. – 2006. – Vol. 574. – P. 63–71.
27 Horikoshi M., Hara K., Ohashi J., Miyake K., Tokunaga K., Ito Ch., Kasuga M., Nagai R., Kadowaki T.A. Polymorphism in the AMPK2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population // Diabetes. – 2006. – Vol. 55. – P. 919 –923.
28 https://www.nur.kz/945272-sovremennoe-sostoyanie-problemy-serd.html.
29 Ganguly P., Alam S.F. Role of homocysteine in the development of cardiovascular disease // Nurt. J. – 2015. – Vol. 14, No. 6. doi: 10.1186/1475-2891-14-6.
30 Ferroni P., Palmirotta R., Martini F., Riondino S., Savonarola A., Spila A., Ciatti F., Sini V., Mariotti S., Del Monte G., Roselli M., Guadagni F. Determinants of homocysteine levels in colorectal and breast cancer patients // Anticancer Res. – 2009. – Vol. 29, No. 10. – P. 4131-4138.
31 Zhang S.M., Willett W.C., Selhub J., Hunter D.J., Giovannucci E.L., Holmes M.D., Colditz G.A., Hankinson S.E. Plasma Folate, Vitamin B6, Vitamin B12, Homocysteine, and Risk of Breast Cancer // J. Natl. Cancer Inst. – 2003. – Vol. 95, No. 5. – P. 373-380. doi: 10.1093/jnci/95.5.373.
32 Arendt J.F.B. et al. Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study // J. Natl. Cancer Inst. – 2013. – Vol. 105, No. 23. – P. 1799–1805.
References
1 Arendt J.F.B. et al. (2013) Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study. J. Natl. Cancer Inst., vol. 105, no. 23, pp. 1799–1805.
2 de Waard F., Baanders van Halewijn E.A. (1974) A prospective study in general practice on breast cancer risk in postmenopausal women. International Journal of Cancer, vol. 14, no. 2. pp. 153–160.
3 Esposito K., Chiodini P., Capuano A. et al. (2013) Metabolic syndrome and postmenopausal breast cancer: systematic review and meta-analysis. Menopause, vol. 20, no. 12. pp. 1301–1309.
4 Fei X. and Michels K.B. (2007) Diabetes, metabolic syndrome and breast cancer: a review of the current evidence. Am. J. Clin. Nutr., vol. 86. pp. 823-835.
5 Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer, vol. 136, no. 5, pp. e359-86. doi: 10.1002/ijc.29210.
6 Ferroni P., Palmirotta R., Martini F., Riondino S., Savonarola A., Spila A., Ciatti F., Sini V., Mariotti S., Del Monte G., Roselli M., Guadagni F. (2009) Determinants of homocysteine levels in colorectal and breast cancer patients. Anticancer Res., vol. 29, no. 10. pp. 4131-4138.
7 Ganguly P., Alam S.F. (2015) Role of homocysteine in the development of cardiovascular disease. Nurt. J., vol. 14, no. 6. doi: 10.1186/1475-2891-14-6.
8 Goldberg J.E., Schwertfeger K.L. (2010) Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics. Current Drug Targets, vol. 11, no. 9. pp. 1133–1146.
9 Grundy S.M., Brewer H.B. Jr., Cleeman J.I., Smith S.C. Jr., Lenfant C. (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation, vol. 109, no. 3. pp. 433–438.
10 Grundy S.M. (2008) Metabolic syndrome pandemic. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28. pp. 629–636.
11 Harvie M., Hooper L., Howell A.H. (2003) Central obesity and breast cancer risk: a systematic review. Obesity Reviews, vol. 4, no. 3. pp. 157–173.
12 Horikoshi M., Hara K., Ohashi J., Miyake K., Tokunaga K., Ito Ch., Kasuga M., Nagai R., Kadowaki T. (2006) A Polymorphism in the AMPK2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population. Diabetes, vol. 55. pp. 919 –923.
13 Howlader N. National Cancer Institute. Breast Cancer Risk Factors. http://www.cancer.gov/ cancertopics/wyntk/breast/page4.
14 https://www.nur.kz/945272-sovremennoe-sostoyanie-problemy-serd.html.
15 Jarde T., Perrier S., Vasson M.P. (2011) Molecular mechanisms of leptin and adiponectin in breast cancer. European Journal of Cancer, vol. 47, no. 1. pp. 33–43.
16 King M.W. AMPK: Master Metabolic Regulator. Medical Biochemistry. http://themedicalbioche- mistry page.org/ampk.php.
17 Largent J.A., McEligot A.J., Ziogas A. (2006) Hypertension, diuretics and breast cancer risk. Journal of Human Hypertension, vol. 20, no. 10. pp. 727–732.
18 Liao S., Li J., Wei W. (2011) Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature. Asian Pacific Journal of Cancer Prevention, vol. 12, no. 4. pp. 1061–1065.
19 Michels K.B., Solomon C.G., Hu F.B. et al. (2003) Type 2 diabetes and subsequent incidence of breast cancer in the nurses' health study. Diabetes Care, vol. 26, no. 6. pp. 1752–1758.
20 Mink P.J., Shahar E., Rosamond W.D. et al. (2002) Serum insulin and glucose levels and breast cancer incidence: the atherosclerosis risk in communities study. The American Journal of Epidemiology, vol. 156, no. 4. pp. 349–352.
21 Motoshima H., Goldstein B.J., Igata M., Araki E. (2006) AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer. J. Physiol., vol. 574. pp. 63–71.
22 Osaki Y., Taniguchi S.I., Tahara A., Okamoto M., Kishimoto T. (2012) Metabolic syndrome and incidence of liver and breast cancers in Japan. Cancer Epidemiology, vol. 36, no. 2. pp. 141–147.
23 Reaven G. M. (1988) Role of insulin resistance in human disease. Diabetes, vol. 37, no. 12. pp. 1595–1607.
24 Rosato V., Bosetti C., Talamini R. et al. (2011) Metabolic syndrome and the risk of breast cancer in postmenopausal women. Annals of Oncology, vol. 22, no. 12, pp. 2687–2692.
25 Rose D.P., Haffner S.M., Baillargeon J. (2007) Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women. Endocrine Reviews, vol. 28, no. 7. pp. 763–777.
26 Soler M., Chatenoud L., Negri E., Parazzini F., Franceschi S., La Vecchia C. (1999) Hypertension and hormone-related neoplasms in women. Hypertension, vol. 34, no. 2. pp. 320–325.
27 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, vol. 106, no. 25, pp. 3143–3421.
28 Tornberg S.A., Holm L-E., Carstensen J.M. (1988) Breast cancer risk in relation to serum cholesterol, serum beta-lipoprotein, height, weight, and blood pressure. Acta Oncologica, vol. 27, no. 1. pp. 31–37.
29 Ursin G., Longnecker M.P., Haile R.W. et al. (1995) A meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology, vol. 6, no. 2. pp. 137–141.
30 van den Brandt P.A., Spiegelman D., Yaun S-S. et al. (2000) Pooled analysis of prospective cohort studies on height, weight and breast cancer risk. American Journal of Epidemiology, vol. 152, no. 6. pp. 514–527.
31 World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation. Geneva, Switzerland: World Health Organization, 1999.
32 Zhang S.M., Willett W.C., Selhub J., Hunter D.J., Giovannucci E.L., Holmes M.D., Colditz G.A., Hankinson S.E. (2003) Plasma Folate, Vitamin B6, Vitamin B12, Homocysteine, and Risk of Breast Cancer. J. Natl. Cancer Inst., vol. 95, no. 5. pp. 373-380. doi: 10.1093/jnci/95.5.373.
2 Howlader N. National Cancer Institute. Breast Cancer Risk Factors. http://www.cancer.gov/ cancertopics/wyntk/breast/page4.
3 Grundy S.M., Brewer H.B. Jr., Cleeman J.I., Smith S.C. Jr, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition // Circulation. – 2004. – Vol. 109, No. 3. – P. 433–438.
4 Reaven G.M. Role of insulin resistance in human disease // Diabetes. – 1988. – Vol. 37, No. 12. – P. 1595–1607.
5 World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation. Geneva, Switzerland: World Health Organization, 1999.
6 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report // Circulation. – 2002. – Vol. 106, No. 25. – P. 3143–3421.
7 Grundy S.M. Metabolic syndrome pandemic // Arteriosclerosis, Thrombosis, and Vascular Biology. – 2008. – Vol. 28. – P. 629–636.
8 Esposito K., Chiodini P., Capuano A., et al. Metabolic syndrome and postmenopausal breast cancer: systematic review and meta-analysis // Menopause. – 2013. – Vol. 20, No. 12. – P. 1301–1309.
9 Osaki Y., Taniguchi S.I., Tahara A., Okamoto M., Kishimoto T. Metabolic syndrome and incidence of liver and breast cancers in Japan // Cancer Epidemiology. – 2012. – Vol. 36, No. 2. – P. 141–147.
10 Rosato V., Bosetti C., Talamini R., et al. Metabolic syndrome and the risk of breast cancer in postmenopausal women // Annals of Oncology. – 2011. – Vol. 22, No. 12. – P. 2687–2692.
11 van den Brandt P.A., Spiegelman D., Yaun S.-S., et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk // American Journal of Epidemiology. – 2000. – Vol. 152, No. 6. – P. 514–527.
12 Harvie M., Hooper L., Howell A.H. Central obesity and breast cancer risk: a systematic review // Obesity Reviews. – 2003. – Vol. 4, No. 3. – P. 157–173.
13 Michels K.B., Solomon C.G., Hu F.B., et al. Type 2 diabetes and subsequent incidence of breast cancer in the nurses' health study // Diabetes Care. – 2003. – Vol. 26, No. 6. – P. 1752–1758.
14 Ursin G., Longnecker M.P., Haile R.W., et al. A meta-analysis of body mass index and risk of premenopausal breast cancer // Epidemiology. – 1995. – Vol. 6, No. 2. – P. 137–141.
15 de Waard F., Baanders van Halewijn E.A. A prospective study in general practice on breast cancer risk in postmenopausal women // International Journal of Cancer. – 1974. – Vol. 14, No. 2. – P. 153–160.
16 Mink P.J., Shahar E., Rosamond W.D., et al. Serum insulin and glucose levels and breast cancer incidence: the atherosclerosis risk in communities study // The American Journal of Epidemiology. – 2002. – Vol. 156, No. 4. – P. 349–352.
17 Tornberg S.A., Holm L.-E., Carstensen J.M. Breast cancer risk in relation to serum cholesterol, serum beta-lipoprotein, height, weight, and blood pressure // Acta Oncologica. – 1988. – Vol. 27, No. 1. – P. 31–37.
18 Soler M., Chatenoud L., Negri E., Parazzini F., Franceschi S., La Vecchia C. Hypertension and hormone-related neoplasms in women // Hypertension. – 1999. – Vol. 34, No. 2. – P. 320–325.
19 Largent JA, McEligot AJ, Ziogas A. Hypertension, diuretics and breast cancer risk // Journal of Human Hypertension. – 2006. – Vol. 20, No. 10. – P. 727–732.
20 Rose D.P., Haffner S.M., Baillargeon J. Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women // Endocrine Reviews. – 2007. – Vol. 28, No. 7. – P. 763–777.
21 Liao S., Li J., Wei W. Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature // Asian Pacific Journal of Cancer Prevention. – 2011. – Vol. 12, No. 4. – P. 1061–1065.
22 Jarde T., Perrier S., Vasson M.P. Molecular mechanisms of leptin and adiponectin in breast cancer // European Journal of Cancer. – 2011. – Vol. 47, No. 1. – P. 33–43.
23 Goldberg J.E., Schwertfeger K.L. Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics // Current Drug Targets. – 2010. – Vol. 11, No. 9. – P. 1133–1146.
24 Fei X. and Michels K.B. Diabetes, metabolic syndrome and breast cancer: a review of the current evidence // Am. J. Clin. Nutr. – 2007. – Vol. 86. – P. 823-835.
25 King M.W. AMPK: Master Metabolic Regulator // Medical Biochemistry. http://themedicalbioche- mistry page.org/ampk.php.
26 Motoshima H., Goldstein B.J., Igata M., Araki E. AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer // J. Physiol. – 2006. – Vol. 574. – P. 63–71.
27 Horikoshi M., Hara K., Ohashi J., Miyake K., Tokunaga K., Ito Ch., Kasuga M., Nagai R., Kadowaki T.A. Polymorphism in the AMPK2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population // Diabetes. – 2006. – Vol. 55. – P. 919 –923.
28 https://www.nur.kz/945272-sovremennoe-sostoyanie-problemy-serd.html.
29 Ganguly P., Alam S.F. Role of homocysteine in the development of cardiovascular disease // Nurt. J. – 2015. – Vol. 14, No. 6. doi: 10.1186/1475-2891-14-6.
30 Ferroni P., Palmirotta R., Martini F., Riondino S., Savonarola A., Spila A., Ciatti F., Sini V., Mariotti S., Del Monte G., Roselli M., Guadagni F. Determinants of homocysteine levels in colorectal and breast cancer patients // Anticancer Res. – 2009. – Vol. 29, No. 10. – P. 4131-4138.
31 Zhang S.M., Willett W.C., Selhub J., Hunter D.J., Giovannucci E.L., Holmes M.D., Colditz G.A., Hankinson S.E. Plasma Folate, Vitamin B6, Vitamin B12, Homocysteine, and Risk of Breast Cancer // J. Natl. Cancer Inst. – 2003. – Vol. 95, No. 5. – P. 373-380. doi: 10.1093/jnci/95.5.373.
32 Arendt J.F.B. et al. Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study // J. Natl. Cancer Inst. – 2013. – Vol. 105, No. 23. – P. 1799–1805.
References
1 Arendt J.F.B. et al. (2013) Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study. J. Natl. Cancer Inst., vol. 105, no. 23, pp. 1799–1805.
2 de Waard F., Baanders van Halewijn E.A. (1974) A prospective study in general practice on breast cancer risk in postmenopausal women. International Journal of Cancer, vol. 14, no. 2. pp. 153–160.
3 Esposito K., Chiodini P., Capuano A. et al. (2013) Metabolic syndrome and postmenopausal breast cancer: systematic review and meta-analysis. Menopause, vol. 20, no. 12. pp. 1301–1309.
4 Fei X. and Michels K.B. (2007) Diabetes, metabolic syndrome and breast cancer: a review of the current evidence. Am. J. Clin. Nutr., vol. 86. pp. 823-835.
5 Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer, vol. 136, no. 5, pp. e359-86. doi: 10.1002/ijc.29210.
6 Ferroni P., Palmirotta R., Martini F., Riondino S., Savonarola A., Spila A., Ciatti F., Sini V., Mariotti S., Del Monte G., Roselli M., Guadagni F. (2009) Determinants of homocysteine levels in colorectal and breast cancer patients. Anticancer Res., vol. 29, no. 10. pp. 4131-4138.
7 Ganguly P., Alam S.F. (2015) Role of homocysteine in the development of cardiovascular disease. Nurt. J., vol. 14, no. 6. doi: 10.1186/1475-2891-14-6.
8 Goldberg J.E., Schwertfeger K.L. (2010) Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics. Current Drug Targets, vol. 11, no. 9. pp. 1133–1146.
9 Grundy S.M., Brewer H.B. Jr., Cleeman J.I., Smith S.C. Jr., Lenfant C. (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation, vol. 109, no. 3. pp. 433–438.
10 Grundy S.M. (2008) Metabolic syndrome pandemic. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28. pp. 629–636.
11 Harvie M., Hooper L., Howell A.H. (2003) Central obesity and breast cancer risk: a systematic review. Obesity Reviews, vol. 4, no. 3. pp. 157–173.
12 Horikoshi M., Hara K., Ohashi J., Miyake K., Tokunaga K., Ito Ch., Kasuga M., Nagai R., Kadowaki T. (2006) A Polymorphism in the AMPK2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population. Diabetes, vol. 55. pp. 919 –923.
13 Howlader N. National Cancer Institute. Breast Cancer Risk Factors. http://www.cancer.gov/ cancertopics/wyntk/breast/page4.
14 https://www.nur.kz/945272-sovremennoe-sostoyanie-problemy-serd.html.
15 Jarde T., Perrier S., Vasson M.P. (2011) Molecular mechanisms of leptin and adiponectin in breast cancer. European Journal of Cancer, vol. 47, no. 1. pp. 33–43.
16 King M.W. AMPK: Master Metabolic Regulator. Medical Biochemistry. http://themedicalbioche- mistry page.org/ampk.php.
17 Largent J.A., McEligot A.J., Ziogas A. (2006) Hypertension, diuretics and breast cancer risk. Journal of Human Hypertension, vol. 20, no. 10. pp. 727–732.
18 Liao S., Li J., Wei W. (2011) Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature. Asian Pacific Journal of Cancer Prevention, vol. 12, no. 4. pp. 1061–1065.
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Как цитировать
Yerezhepov, D., Manarbek, L., & Akilzhanova А. (2018). Генетический профиль, метаболический синдром и риск развития рака молочной железы среди женщин Казахстана. Вестник КазНУ. Серия биологическая, 74(1), 74–87. https://doi.org/10.26577/eb-2018-1-1317
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МОЛЕКУЛЯРНАЯ БИОЛОГИЯ И ГЕНЕТИКА
