Salvestrols are strong anticancer plant antioxidants.
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Keywords:
polyphenols, cytochrome P450 CYP1B1, salvestrols, piceatannol,Abstract
It was found that a new group of polyphenols – salvestrols are strong anticancer agents. A particular enzyme – cytochrome P450 CYP1B1 presenting in all types of human cancer cells converts salvestrols to the strong anticancer toxin piceatannol, which kills cancer cell (apoptosis). This toxin is not synthesized in normal healthy cells. Salvestrols are synthesized in fruits and green leaves of a range lants.References
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2 Han X., Shen T., Lou H. Dietary Polyphenols and Their Biological Significance // International Journal of Molecular Sciences 2007. – 8. – Р. 950-988.
3 Oueslati S., Ksouri R., Falleh H., Pichette A., Abdelly C., Legault J. Phenolic content, antioxidant, anti-inflammatory and anticancer ctivities of the edible halophyte Suaeda fruticosa Forssk // Food Chemistry. – 2012. – V 132, Issue 2. – P. 943–947.
4 Ullah S., Bano A., Girmay S., Tan G. Anticancer, antioxidant and antimicrobial activities of Suaeda fruticosa related to its phytochemical screening // Intern. J. PhytoMed. – 2012. – Vol 4, No2.
5 Tan H.L., Butler P.C., Burke M.D., Potter G.A. Salvestrols: a new perspective in nutritional research // J Orthomol Med. – 2008. – 22. – Р. 40-47.
6 Potter G.A., Patterson L.H., Wanogho E. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 // Br J Cancer – 2002. – 86. – Р. 774-778.
7 Kamel A. M. Metabolic transformations of хenobiotics (Introduction of Biotransformation reactions) // Bioanalytical Course. University of Connecticut – 2007. – р 55.
8 Ortiz de Montellano, Paul R. Cytochrome P450: structure, mechanism, and biochemistry. — 3rd edition. — New York: Kluwer Academic/Plenum Publishers, 2005.
9 Murray G.I., Taylor M.C., McFadyen M.C., et al. Tumor-specific expression of cytochrome P450 CYP1B1 // Cancer Res. –1997. – 57. – Р. 3026-3031.
10 McFadyen M.C., Cruickshank M.E., Miller I.D., et al. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer // Br J Cancer. – 2001. – 85. – Р. 242-246.
11 Magee JB, Smith BJ. Resveratrol content of muscadine berries is affected by disease control spray program // HortScience. – 2008. – 37. – Р. 251.
12 Vainio H, Weiderpass E. Fruit and vegetables in cancer prevention // Nutr Cancer. – 2006. – 54. – Р. 111-142.
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Erezhepov, A. E., Serikbaeva, A. B., Alikulov, Z., & Begzat, A. (2015). Salvestrols are strong anticancer plant antioxidants. Experimental Biology, 60(1), 164–167. Retrieved from https://bb.kaznu.kz/index.php/biology/article/view/82
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Biomedicine
